Protein

Protein accession
A0A6J5L3F0 [UniProt]
Representative
5IWUp
Source
UniProt (cluster: phalp2_17543)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 93% (predicted by ML model)
Protein sequence
MRLSKEGRDFILRFESVLNEIFIQQCEDYLTARFESLPQNQFDSLVDFMHNVGIFESYGSELFLQLDFNPDTVDPYEFDRWIYNRKGRKSESVKNRSIAERLLFTTGVYKDDYREDKDH
Physico‐chemical
properties
protein length:119 AA
molecular weight:14324,8 Da
isoelectric point:4,81
hydropathy:-0,71
Representative Protein Details
Accession
5IWUp
Protein name
5IWUp
Sequence length
434 AA
Molecular weight
47751,50500 Da
Isoelectric point
5,15100
Sequence
VGNIYFISRDGNSWMELHNDGFVDIYGNLDISIRSEASVNIRADLDVNIEAGNSVNIKANGEGGIKLQADIANIDLSSANYYCTVSEDLNLLAKNVFVESEEESHFKNREFLVKAETNINMRGDNQLRFASDANISFTTGQNINFDGTRVDSNTGSGDLPSDADAANPATKIKSKVFLDIDFDQIGGATEENLESCVSRLPRHEPWPDHAVSPGSERISPNPEETGEEPPINASVGSVAEKAARPLPVVGSPKKGMSPGIYEPVSYEGDQPVYRNTGNQGDLIPAKDRVISPQGIEFIKKEEGFAPRKYPDGGKNRFSIGYGHQITGREPFDPEKGWTKQQATQVLTQDLEKFQAAVRKAVTAKVTQNQFDALTSFAFNVGIGALQKSTLVKKLNEGNYQEVPNEFMKWVFSEGKRNQGLIKRRRKEALLFTTP
Other Proteins in cluster: phalp2_17543
Total (incl. this protein): 3 Avg length: 240,3 Avg pI: 6,35
Protein ID Length (AA) pI
5IWUp 434 5,15100
A0AAE9K6P6 168 9,09773
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_37702
496b4
 7 34,9% 449 2.550E-56
2 phalp2_33749
10T6t
 3 23,7% 657 1.102E-26
3 phalp2_39498
5k0e3
 3 23,6% 512 6.855E-24
4 phalp2_13752
6LU4E
 2 30,4% 286 5.249E-23

Domains

Domains [InterPro]

No domain annotations available.

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR796199 [NCBI]
CDS location
range 1343 -> 1702
strand -
CDS
ATGAGACTATCAAAAGAAGGAAGAGATTTCATTCTTCGATTCGAATCTGTCCTCAATGAGATTTTCATCCAGCAGTGTGAAGACTACTTGACAGCCAGATTCGAATCATTACCACAAAACCAATTTGACAGTTTAGTTGATTTCATGCATAATGTAGGTATATTCGAATCGTATGGTAGTGAGTTGTTTTTACAACTTGACTTCAATCCTGATACTGTTGACCCATACGAGTTTGACAGATGGATATACAACAGAAAAGGACGCAAGTCTGAATCTGTAAAGAATCGCAGCATTGCAGAGCGTTTGTTGTTCACAACAGGAGTGTACAAAGATGACTATAGAGAAGATAAAGATCACTAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (5IWUp) rather than this protein.
PDB ID
5IWUp
Method AlphaFoldv2
Resolution 80.94
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50