Protein

UniProt accession
Q9ZX49 [UniProt]
Protein name
N-acetylmuramoyl-L-alanine amidase
PhaLP type
endolysin

evidence: GO annotation

probability: 99 % (predicted by ML model)

Protein sequence
MSFTRFLQDDPLLTREQVMAELIRVADELNMPDKRGACVIAGMTISQEVGVKDNDPPFERRFWCPANRADPESFNYPHDSESNDGRSVGYFQQQKGPNGELWWGTTASEMNLHSAATQFMTRLKAAGYNASNAQAANDSAQAIQRSGVPQAYKQWWDDINRLYDKVKGSGGGPAPAPKPPQSGPWTGDPVWLADVLRAEGLNVVELPGWLDRGHGDMGRLWGVVCHHTGSDNTPSSEIAFHPSLGLCSQIHLARNGTVTLCGVGIAWHAGVGSYPGLPEDNANAVTIGIEAQNSGTYDGAPHRTNWPDAQYDAYVKCCAAICRRLGVRADHVISHKEWAGRKQGKWDPGAIDMNIFRADVQRRIDAHQPNGEDDFMAALSADEQREVLNLLRVLADRRFVSRSPFRHLGEGPSETVAGFGLNTDGLNHAQYTIELARLGDPTHLALLREVASAEGDSRYPDRQYDAKLAKRVLAEIEGAATAPAKPSTPSAPTEPAPEAPTPPVKAACALSAAGCVVAGSTSGGGCALSTDGTGKCVVTAATDGGAA
Physico‐chemical
properties
protein length:547 AA
molecular weight:58581,00000 Da
isoelectric point:5,55427
aromaticity:0,06947
hydropathy:-0,43766

Domains

Domains [InterPro]
IPR051206
265–380
IPR051206
IPR002502
222–349
IPR002502
IPR036505
202–366
IPR036505
IPR002502
221–349
IPR002502
IPR002502
208–349
IPR002502
IPR036505
212–366
IPR036505
Protein sequence: Q9ZX49
1 547
Legend: Pfam SMART CDD TIGRFAM HAMAP SUPFAM PRINTS Gene3D PANTHER Other

Taxonomy

  Name Taxonomy ID Lineage
Phage Mycobacterium phage TM4 (Mycobacteriophage TM4)
[NCBI] 		88870 Timquatrovirus > Mycobacterium virus TM4
Host Mycobacterium
[NCBI] 		1763 Bacteria > Actinobacteria > Actinobacteria > Corynebacteriales > Mycobacteriaceae >
Host Mycobacterium avium
[NCBI] 		1764 Bacteria > Actinobacteria > Actinobacteria > Corynebacteriales > Mycobacteriaceae > Mycobacterium
Host Mycobacterium smegmatis
[NCBI] 		1772 Bacteria > Actinobacteria > Actinobacteria > Corynebacteriales > Mycobacteriaceae > Mycobacterium

Coding sequence (CDS)

Coding sequence (CDS)
Genbank protein accession
AAD17596.1 [NCBI]
Genbank nucleotide accession
AF068845 [NCBI]
CDS location
range 23341 -> 24984
strand +
CDS
ATGAGTTTCACCCGGTTCCTGCAGGATGACCCGCTGCTCACCCGCGAGCAAGTGATGGCCGAGCTGATTCGGGTCGCCGACGAGCTGAACATGCCCGACAAGCGCGGCGCCTGCGTCATTGCGGGCATGACGATTTCGCAAGAGGTCGGCGTAAAGGACAACGACCCGCCGTTCGAGCGGCGGTTCTGGTGCCCGGCCAACCGCGCCGACCCCGAATCGTTCAACTACCCGCACGACTCGGAATCGAACGACGGCCGCTCGGTCGGCTACTTCCAGCAGCAGAAGGGGCCTAACGGCGAGCTGTGGTGGGGCACAACGGCATCCGAGATGAACCTGCACAGCGCCGCGACGCAGTTTATGACGCGGCTCAAGGCGGCCGGATACAACGCGAGCAACGCCCAGGCGGCGAACGACTCGGCGCAGGCGATCCAGCGGTCGGGCGTCCCGCAGGCGTACAAGCAATGGTGGGACGACATTAACCGCCTGTACGACAAGGTGAAGGGCTCGGGCGGTGGCCCGGCGCCCGCGCCTAAGCCGCCGCAGTCGGGGCCGTGGACCGGCGACCCGGTGTGGCTGGCCGACGTGCTGCGCGCCGAGGGGCTGAACGTCGTCGAGCTGCCCGGCTGGCTCGACCGCGGGCACGGCGACATGGGCCGCTTGTGGGGCGTGGTGTGCCATCACACCGGCAGCGATAACACCCCGTCGAGCGAGATTGCGTTTCACCCGTCGCTCGGCCTGTGCTCGCAGATTCACCTGGCGCGCAACGGAACTGTGACGCTGTGCGGTGTCGGCATCGCCTGGCATGCGGGCGTCGGCAGCTATCCCGGCCTGCCCGAGGACAACGCCAACGCGGTCACTATCGGCATCGAGGCCCAAAACAGCGGCACCTATGACGGCGCACCGCACCGGACGAATTGGCCTGACGCGCAATACGACGCCTATGTGAAGTGCTGCGCCGCGATCTGCCGCCGCCTCGGCGTGCGCGCCGATCACGTGATCAGTCACAAGGAATGGGCCGGGCGCAAGCAAGGCAAATGGGATCCAGGCGCCATCGACATGAACATCTTTCGCGCCGACGTACAGCGGCGCATCGACGCCCATCAACCAAACGGAGAGGACGATTTCATGGCCGCACTATCAGCCGACGAGCAGCGCGAGGTGCTGAACCTGCTGCGCGTCCTGGCCGACCGGCGGTTCGTCAGCCGCAGCCCGTTCCGCCACCTTGGCGAGGGGCCGAGCGAAACTGTCGCCGGGTTCGGGCTCAACACCGACGGCCTCAATCACGCGCAGTACACGATTGAGCTTGCGCGCCTGGGCGACCCGACGCACCTCGCCCTGCTGCGCGAGGTCGCCAGCGCCGAGGGTGACTCGCGCTATCCCGACCGGCAGTACGACGCCAAGCTCGCCAAGCGCGTGCTCGCCGAAATCGAGGGCGCCGCAACGGCACCGGCCAAGCCGAGCACGCCGAGCGCCCCGACCGAGCCCGCCCCCGAGGCGCCCACGCCGCCGGTCAAGGCCGCGTGTGCGCTGTCTGCGGCCGGGTGCGTGGTGGCTGGCTCGACCTCGGGCGGTGGCTGCGCCCTGTCCACCGACGGCACCGGCAAGTGCGTTGTGACCGCCGCGACCGACGGCGGGGCCGCCTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell Biological process Inferred from Electronic Annotation (InterPro)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity Molecular function Inferred from Electronic Annotation (UniProt)
GO:0009253 peptidoglycan catabolic process Biological process Inferred from Electronic Annotation (InterPro)
GO:0009254 peptidoglycan turnover Biological process Inferred from Electronic Annotation (TreeGrafter)
GO:0042742 defense response to bacterium Biological process Inferred from Electronic Annotation (UniProt)
GO:0071555 cell wall organization Biological process Inferred from Electronic Annotation (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 N-acetylmuramoyl-L-alanine amidase residues in certain cell-wall glycopeptides
Hydrolases
Acting on carbon-nitrogen bonds, other than peptide bonds
In linear amides
 match to sequence model evidence used in automatic assertion
ECO:0000256 		ARBA:ARBA00001561

Tertiary structure

No tertiary structures available.