Protein

UniProt accession

P19385 [UniProt]

Protein name

Lysozyme

PhaLP type

endolysin

evidence: UniProt function annotation

probability: 99 % (predicted by ML model)

Protein sequence

MVKKNDLFVDVASHQGYDISGILEEAGTTNTIIKVSESTSYLNPCLSAQVSQSNPIGFYHFAWFGGNEEEAEAEARYFLDNVPTQVKYLVLDYEDHASASVQRNTTACLRFMQIIAEAGYTPIYYSYKPFTLDNVDYQQILAQFPNSLWIAGYGLNDGTANFEYFPSMDGIRWWQYSSNPFDKNIVLLDDEKEDNINNENTLKSLTTVANEVIQGLWGNGQERYDSLANAGYDPQAVQDKVNEILNAREIADLTTVANEVIQGLWGNGQERYDSLANAGYDPQAVQDKVNEILNAREIADLTTVANEVIQGLWGNGQERYDSLANAGYDPQAVQDKVNELLS

Physico‐chemical properties

protein length:	342 AA
molecular weight:	38248,00000 Da
isoelectric point:	4,18178
aromaticity:	0,11111
hydropathy:	-0,43918

Domains

Domains [InterPro]

IPR013168

301–342

IPR013168 IPR002053 IPR013168

IPR008270

10–43

IPR008270 IPR018077

IPR017853

6–185

IPR017853

IPR002053

9–180

IPR002053

Protein sequence: P19385

1 342

Legend: Pfam SMART CDD TIGRFAM HAMAP SUPFAM PRINTS Gene3D PANTHER Other

Domains [InterPro]

InterPro ID	Start	End	Source	Name
IPR013168	301	342	SMART	Cpl-7 lysozyme, C-terminal
IPR002053	5	210	Pfam	Glycoside hydrolase, family 25
IPR013168	255	293	SMART	Cpl-7 lysozyme, C-terminal
IPR008270	10	43	PROSITE	Glycosyl hydrolases family 25, active site
IPR017853	6	185	SUPFAM	Glycoside hydrolase superfamily
IPR018077	85	196	SMART	Glycoside hydrolase, family 25 subgroup
IPR002053	9	180	Pfam	Glycoside hydrolase, family 25

Taxonomy

	Name	Taxonomy ID	Lineage
Phage	Streptococcus phage Cp-7 (Bacteriophage Cp-7) [NCBI]	10748	Salasmaviridae > Cepunavirus > Cepunavirus Cp7
Host	Streptococcus pneumoniae [NCBI]	1313	Bacteria > Firmicutes > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus

Coding sequence (CDS)

Genbank protein accession

AAA72844.2 [NCBI]

Genbank nucleotide accession

M34779 [NCBI]

CDS location

range 286 -> 1314
strand +

CDS

ATGGTTAAGAAAAATGATTTATTTGTAGACGTTGCAAGCCATCAAGGCTACGACATTTCAGGAATTTTAGAAGAAGCAGGGACAACAAACACAATTATTAAAGTGTCAGAAAGTACAAGCTATTTAAACCCTTGCTTGTCTGCTCAAGTGAGCCAGTCAAATCCTATCGGGTTTTATCATTTTGCTTGGTTTGGTGGAAATGAAGAAGAAGCAGAAGCAGAAGCACGCTATTTCCTTGATAACGTGCCTACACAAGTTAAATACCTTGTACTAGATTATGAAGACCATGCAAGCGCAAGCGTACAAAGAAACACTACCGCGTGCTTACGCTTTATGCAAATTATCGCAGAAGCTGGATATACACCTATTTATTATAGTTACAAACCGTTTACGCTTGATAATGTGGACTATCAGCAGATTTTAGCACAGTTCCCTAATTCTCTATGGATTGCAGGCTATGGCTTAAATGATGGTACAGCTAACTTTGAATACTTTCCAAGCATGGACGGTATCAGATGGTGGCAATATTCTAGTAACCCGTTTGACAAGAATATTGTACTGTTAGATGATGAGAAAGAAGATAATATAAACAATGAAAACACTCTAAAAAGCCTTACCACAGTAGCCAACGAGGTCATTCAGGGACTTTGGGGCAACGGTCAAGAACGTTATGACAGTTTAGCGAATGCAGGGTATGACCCCCAAGCGGTTCAAGACAAAGTGAATGAAATCTTAAACGCTAGAGAAATTGCAGACCTTACCACAGTAGCCAACGAGGTCATTCAGGGACTTTGGGGCAACGGTCAAGAACGTTATGACAGTTTAGCGAATGCAGGGTATGACCCCCAAGCGGTTCAAGACAAAGTGAATGAAATCTTAAACGCTAGAGAAATTGCAGACCTTACCACAGTAGCCAACGAGGTCATTCAGGGACTTTGGGGCAACGGTCAAGAACGTTATGACAGTTTAGCGAATGCAGGGTATGACCCCCAAGCGGTTCAAGACAAAGTGAATGAATTACTTTCATAA

Gene Ontology

	Description	Category	Evidence (source)
GO:0003796	lysozyme activity	Molecular function	Inferred from Electronic Annotation (UniProt)
GO:0009253	peptidoglycan catabolic process	Biological process	Inferred from Electronic Annotation (InterPro)
GO:0016052	carbohydrate catabolic process	Biological process	Inferred from Electronic Annotation (TreeGrafter)
GO:0016998	cell wall macromolecule catabolic process	Biological process	Inferred from Electronic Annotation (InterPro)
GO:0031640	killing of cells of another organism	Biological process	Inferred from Electronic Annotation (UniProt)
GO:0042742	defense response to bacterium	Biological process	Inferred from Electronic Annotation (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID: 4CVD

Method: X-ray crystallography

Resolution: 1.666

Chain position: A

View on RCSB