Protein

UniProt accession
P16009 [UniProt]
Protein name
Pre-baseplate central spike protein Gp5
PhaLP type
endolysin

evidence: UniProt function annotation

probability: 99 % (predicted by ML model)

Protein sequence
MEMISNNLNWFVGVVEDRMDPLKLGRVRVRVVGLHPPQRAQGDVMGIPTEKLPWMSVIQPITSAAMSGIGGSVTGPVEGTRVYGHFLDKWKTNGIVLGTYGGIVREKPNRLEGFSDPTGQYPRRLGNDTNVLNQGGEVGYDSSSNVIQDSNLDTAINPDDRPLSEIPTDDNPNMSMAEMLRRDEGLRLKVYWDTEGYPTIGIGHLIMKQPVRDMAQINKVLSKQVGREITGNPGSITMEEATTLFERDLADMQRDIKSHSKVGPVWQAVNRSRQMALENMAFQMGVGGVAKFNTMLTAMLAGDWEKAYKAGRDSLWYQQTKGRASRVTMIILTGNLESYGVEVKTPARSLSAMAATVAKSSDPADPPIPNDSRILFKEPVSSYKGEYPYVHTMETESGHIQEFDDTPGQERYRLVHPTGTYEEVSPSGRRTRKTVDNLYDITNADGNFLVAGDKKTNVGGSEIYYNMDNRLHQIDGSNTIFVRGDETKTVEGNGTILVKGNVTIIVEGNADITVKGDATTLVEGNQTNTVNGNLSWKVAGTVDWDVGGDWTEKMASMSSISSGQYTIDGSRIDIG
Physico‐chemical
properties
protein length:575 AA
molecular weight:63116,00000 Da
isoelectric point:5,28906
aromaticity:0,06609
hydropathy:-0,48452

Domains

Domains [InterPro]
IPR046397
3–575
IPR046397
IPR023346
130–343
IPR023346 IPR010609
IPR009590
33–173
IPR009590 IPR001165
IPR052619
172–339
IPR052619
IPR023347
174–342
IPR023347
IPR002196
183–310
IPR002196
Protein sequence: P16009
1 575
Legend: Pfam SMART CDD TIGRFAM HAMAP SUPFAM PRINTS Gene3D PANTHER Other

Taxonomy

  Name Taxonomy ID Lineage
Phage Enterobacteria phage T4 (Bacteriophage T4)
[NCBI] 		10665 Straboviridae > Tequatrovirus >
Host Escherichia coli
[NCBI] 		562 Bacteria > Proteobacteria > Gammaproteobacteria > Enterobacteriales > Enterobacteriaceae > Escherichia

Coding sequence (CDS)

Coding sequence (CDS)
Genbank protein accession
- [NCBI]
Genbank nucleotide accession
X14845 [NCBI]
CDS location
range ->
strand
CDS

  




        

        
          

        
      
        

          
Genbank protein accession

          

            CAA33749.1 
            [NCBI]
          


          
Genbank nucleotide accession

          

            X15728
            [NCBI]
          


          
CDS location

          

            range 1030 -> 2757

            strand +
          



CDS



  

    
ATGGAAATGATAAGTAATAACCTTAATTGGTTTGTCGGTGTTGTTGAAGATAGAATGGACCCATTAAAATTAGGTCGTGTTCGTGTTCGTGTGGTTGGTCTGCATCCACCTCAAAGAGCACAAGGTGATGTAATGGGTATTCCAACTGAAAAATTACCATGGATGTCAGTTATTCAACCTATAACTTCTGCAGCAATGTCTGGAATTGGAGGTTCTGTTACTGGACCAGTAGAAGGAACTAGAGTTTATGGTCATTTTTTAGACAAATGGAAAACTAATGGAATTGTCCTTGGCACGTATGGTGGAATAGTTCGCGAAAAACCGAATAGACTTGAAGGATTTTCTGACCCAACTGGGCAGTATCCTAGACGTTTAGGAAATGATACTAACGTACTAAACCAAGGTGGAGAAGTAGGATATGATTCGTCTTCTAACGTTATCCAAGATAGTAACTTAGACACCGCAATAAATCCCGATGATAGACCGCTATCAGAGATTCCGACCGATGATAATCCAAATATGTCAATGGCTGAAATGCTTCGCCGTGATGAAGGATTAAGATTAAAAGTTTATTGGGATACCGAAGGATATCCGACAATTGGTATTGGTCATCTTATCATGAAGCAGCCAGTTCGTGATATGGCTCAAATTAATAAAGTTTTATCAAAACAAGTTGGTCGTGAAATTACAGGAAATCCAGGTTCTATTACAATGGAAGAGGCGACGACTTTATTTGAGCGTGATTTGGCTGATATGCAACGGGACATTAAATCACATTCTAAAGTAGGACCAGTCTGGCAAGCTGTCAACCGTTCTCGTCAAATGGCGTTAGAAAATATGGCATTTCAGATGGGTGTTGGTGGTGTAGCTAAATTTAACACAATGTTAACTGCTATGTTAGCAGGAGATTGGGAAAAAGCGTATAAAGCCGGTCGTGATTCATTGTGGTATCAACAAACAAAAGGCCGTGCATCCCGTGTTACCATGATTATTCTTACGGGGAATTTGGAATCATATGGTGTTGAAGTGAAAACCCCAGCTAGGTCTCTATCAGCAATGGCTGCTACTGTAGCTAAATCTTCTGACCCTGCTGACCCTCCTATTCCAAATGACTCGAGAATTTTATTCAAAGAACCAGTTTCTTCATATAAAGGTGAATATCCTTATGTGCATACAATGGAAACTGAAAGCGGACATATTCAGGAATTTGATGATACCCCTGGGCAAGAACGATATAGATTAGTTCATCCAACTGGAACTTATGAAGAAGTATCACCATCAGGAAGAAGAACAAGAAAAACTGTTGATAATTTGTATGATATAACCAATGCTGATGGTAATTTTTTGGTAGCCGGTGATAAAAAGACTAACGTCGGTGGTTCAGAAATTTATTATAACATGGATAATCGTTTACATCAAATCGATGGAAGCAATACAATATTTGTACGTGGAGACGAAACGAAAACTGTTGAAGGTAATGGAACTATCCTAGTTAAAGGTAATGTTACTATTATAGTTGAAGGTAATGCTGACATTACAGTTAAAGGAGATGCTACCACTTTAGTTGAAGGAAATCAAACTAACACAGTAAATGGAAATCTTTCTTGGAAAGTTGCCGGGACAGTTGATTGGGATGTCGGTGGTGATTGGACAGAAAAAATGGCATCTATGAGTTCTATTTCATCTGGTCAATACACAATTGATGGATCGAGGATTGACATTGGCTAA

  




        

        
          

        
      
        

          
Genbank protein accession

          

            AAD42482.1 
            [NCBI]
          


          
Genbank nucleotide accession

          

            AF158101
            [NCBI]
          


          
CDS location

          

            range 77959 -> 79686

            strand +
          



CDS



  

    
ATGGAAATGATAAGTAATAACCTTAATTGGTTTGTCGGTGTTGTTGAAGATAGAATGGACCCATTAAAATTAGGTCGTGTTCGTGTTCGTGTGGTTGGTCTGCATCCACCTCAAAGAGCACAAGGTGATGTAATGGGTATTCCAACTGAAAAATTACCATGGATGTCAGTTATTCAACCTATAACTTCTGCAGCAATGTCTGGAATTGGAGGTTCTGTTACTGGACCAGTAGAAGGAACTAGAGTTTATGGTCATTTTTTAGACAAATGGAAAACTAATGGAATTGTCCTTGGCACGTATGGTGGAATAGTTCGCGAAAAACCGAATAGACTTGAAGGATTTTCTGACCCAACTGGGCAGTATCCTAGACGTTTAGGAAATGATACTAACGTACTAAACCAAGGTGGAGAAGTAGGATATGATTCGTCTTCTAACGTTATCCAAGATAGTAACTTAGACACCGCAATAAATCCCGATGATAGACCGCTATCAGAGATTCCGACCGATGATAATCCAAATATGTCAATGGCTGAAATGCTTCGCCGTGATGAAGGATTAAGATTAAAAGTTTATTGGGATACCGAAGGATATCCGACAATTGGTATTGGTCATCTTATCATGAAGCAGCCAGTTCGTGATATGGCTCAAATTAATAAAGTTTTATCAAAACAAGTTGGTCGTGAAATTACAGGAAATCCAGGTTCTATTACAATGGAAGAGGCGACGACTTTATTTGAGCGTGATTTGGCTGATATGCAACGGGACATTAAATCACATTCTAAAGTAGGACCAGTCTGGCAAGCTGTCAACCGTTCTCGTCAAATGGCGTTAGAAAATATGGCATTTCAGATGGGTGTTGGTGGTGTAGCTAAATTTAACACAATGTTAACTGCTATGTTAGCAGGAGATTGGGAAAAAGCGTATAAAGCCGGTCGTGATTCATTGTGGTATCAACAAACAAAAGGCCGTGCATCCCGTGTTACCATGATTATTCTTACGGGGAATTTGGAATCATATGGTGTTGAAGTGAAAACCCCAGCTAGGTCTCTATCAGCAATGGCTGCTACTGTAGCTAAATCTTCTGACCCTGCTGACCCTCCTATTCCAAATGACTCGAGAATTTTATTCAAAGAACCAGTTTCTTCATATAAAGGTGAATATCCTTATGTGCATACAATGGAAACTGAAAGCGGACATATTCAGGAATTTGATGATACCCCTGGGCAAGAACGATATAGATTAGTTCATCCAACTGGAACTTATGAAGAAGTATCACCATCAGGAAGAAGAACAAGAAAAACTGTTGATAATTTGTATGATATAACCAATGCTGATGGTAATTTTTTGGTAGCCGGTGATAAAAAGACTAACGTCGGTGGTTCAGAAATTTATTATAACATGGATAATCGTTTACATCAAATCGATGGAAGCAATACAATATTTGTACGTGGAGACGAAACGAAAACTGTTGAAGGTAATGGAACTATCCTAGTTAAAGGTAATGTTACTATTATAGTTGAAGGTAATGCTGACATTACAGTTAAAGGAGATGCTACCACTTTAGTTGAAGGAAATCAAACTAACACAGTAAATGGAAATCTTTCTTGGAAAGTTGCCGGGACAGTTGATTGGGATGTCGGTGGTGATTGGACAGAAAAAATGGCATCTATGAGTTCTATTTCATCTGGTCAATACACAATTGATGGATCGAGGATTGACATTGGCTAA

  




        

        
      
    
  






  

  
  

    
Gene Ontology


  





  


    
    

      

        
          

            
            Description
            Category
            Evidence (source)
          

        
        
          
          

            
              
                GO:0003796
              
            
            lysozyme activity
            Molecular function
            Inferred from Electronic Annotation (UniProt)
          

          
          

            
              
                GO:0009253
              
            
            peptidoglycan catabolic process
            Biological process
            Inferred from Electronic Annotation (InterPro)
          

          
          

            
              
                GO:0016998
              
            
            cell wall macromolecule catabolic process
            Biological process
            Inferred from Electronic Annotation (InterPro)
          

          
          

            
              
                GO:0031640
              
            
            killing of cells of another organism
            Biological process
            Inferred from Electronic Annotation (UniProt)
          

          
          

            
              
                GO:0042742
              
            
            defense response to bacterium
            Biological process
            Inferred from Electronic Annotation (UniProt)
          

          
          

            
              
                GO:0042802
              
            
            identical protein binding
            Molecular function
            Inferred from Electronic Annotation (UniProt)
          

          
          

            
              
                GO:0044409
              
            
            symbiont entry into host
            Biological process
            Inferred from Electronic Annotation (InterPro)
          

          
          

            
              
                GO:0046718
              
            
            symbiont entry into host cell
            Biological process
            Inferred from Electronic Annotation (InterPro)
          

          
          

            
              
                GO:0098003
              
            
            viral tail assembly
            Biological process
            Inferred from Electronic Annotation (UniProt)
          

          
          

            
              
                GO:0098015
              
            
            virus tail
            Cellular component
            Inferred from Electronic Annotation (UniProt)
          

          
          

            
              
                GO:0098025
              
            
            virus tail, baseplate
            Cellular component
            Inferred from Electronic Annotation (UniProt)
          

          
          

            
              
                GO:0098932
              
            
            symbiont entry into host cell via disruption of host cell wall peptidoglycan
            Biological process
            Inferred from Electronic Annotation (UniProt)
          

          
          

            
              
                GO:0098994
              
            
            symbiont entry into host cell via disruption of host cell envelope
            Biological process
            Inferred from Electronic Annotation (UniProt)
          

          
        
      

    

    

  





  

  
  

    
Enzymatic activity


  





  

    
      

        

          
            

              EC Number
              Entry Name
              Reaction Catalyzed
              Classification
              Evidence
              Source
            

          
          
            
              

                
                  
                    3.2.1.17
                  
                
                
                  lysozyme
                  
                    
aka muramidase
                  
                		
                D-glucosamine residues in chitodextrins
                
                  
Hydrolases

                  
Glycosylases

                  
Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds

                		
                
                  match to sequence model evidence used in automatic assertion
                  
ECO:0000255
                		
                

  
    HAMAP-Rule:MF_04151
  


                
              

            
          
        

      

    
  




  

  
  

    
Tertiary structure


  





  

    
      
        

          
          

            
PDB ID: 4KU0

            
Method: X-ray crystallography

            
Resolution: 1.15

            
Chain position: A,B,C,D

            

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