Protein

UniProt accession

P15057 [UniProt]

Protein name

Lysozyme

PhaLP type

endolysin

evidence: UniProt function annotation

probability: 99 % (predicted by ML model)

Protein sequence

MVKKNDLFVDVSSHNGYDITGILEQMGTTNTIIKISESTTYLNPCLSAQVEQSNPIGFYHFARFGGDVAEAEREAQFFLDNVPMQVKYLVLDYEDDPSGDAQANTNACLRFMQMIADAGYKPIYYSYKPFTHDNVDYQQILAQFPNSLWIAGYGLNDGTANFEYFPSMDGIRWWQYSSNPFDKNIVLLDDEEDDKPKTAGTWKQDSKGWWFRRNNGSFPYNKWEKIGGVWYYFDSKGYCLTSEWLKDNEKWYYLKDNGAMATGWVLVGSEWYYMDDSGAMVTGWVKYKNNWYYMTNERGNMVSNEFIKSGKGWYFMNTNGELADNPSFTKEPDGLITVA

Physico‐chemical properties

protein length:	339 AA
molecular weight:	39190,00000 Da
isoelectric point:	4,61688
aromaticity:	0,17109
hydropathy:	-0,59676

Domains

Domains [InterPro]

IPR002053

9–180

IPR002053 IPR018337 IPR018337 IPR018337

IPR018077

85–197

IPR018077 IPR008270

IPR017853

6–185

IPR017853

IPR002053

5–206

IPR002053

Protein sequence: P15057

1 339

Legend: Pfam SMART CDD TIGRFAM HAMAP SUPFAM PRINTS Gene3D PANTHER Other

Domains [InterPro]

InterPro ID	Start	End	Source	Name
IPR002053	9	180	Pfam	Glycoside hydrolase, family 25
IPR018077	85	197	SMART	Glycoside hydrolase, family 25 subgroup
IPR017853	6	185	SUPFAM	Glycoside hydrolase superfamily
IPR018337	221	238	PROSITE	Cell wall/choline-binding repeat
IPR018337	261	306	PROSITE	Cell wall/choline-binding repeat
IPR002053	5	206	Pfam	Glycoside hydrolase, family 25
IPR008270	10	43	PROSITE	Glycosyl hydrolases family 25, active site
IPR018337	241	260	PROSITE	Cell wall/choline-binding repeat

Taxonomy

	Name	Taxonomy ID	Lineage
Phage	Streptococcus phage Cp-1 (Bacteriophage Cp-1) [NCBI]	10747	Salasmaviridae > Cepunavirus > Cepunavirus Cp1
Host	Streptococcus pneumoniae [NCBI]	1313	Bacteria > Firmicutes > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus

Coding sequence (CDS)

Genbank protein accession

CAA87744.1 [NCBI]

Genbank nucleotide accession

Z47794 [NCBI]

CDS location

range 16429 -> 17448
strand +

CDS

ATGGTTAAAAAGAATGATTTATTTGTAGATGTTTCAAGTCACAACGGTTACGATATAACAGGTATCTTGGAGCAAATGGGAACAACTAACACCATCATTAAAATTTCTGAAAGTACGACCTATTTAAACCCTTGCTTGTCTGCTCAAGTGGAGCAGTCAAACCCTATTGGCTTTTATCACTTCGCACGCTTTGGCGGAGACGTAGCAGAAGCCGAAAGAGAAGCGCAGTTTTTCCTTGACAACGTGCCTATGCAAGTTAAATACCTTGTATTGGACTACGAGGACGACCCAAGCGGAGACGCACAAGCGAACACTAACGCATGCTTACGCTTTATGCAGATGATTGCTGACGCTGGATATAAACCTATTTATTATAGTTATAAACCGTTTACACATGATAATGTGGACTATCAGCAAATCCTTGCACAGTTCCCTAATTCTCTATGGATTGCAGGCTATGGCTTAAACGATGGTACAGCTAACTTTGAATACTTCCCAAGCATGGACGGGATAAGATGGTGGCAGTATTCTAGTAACCCGTTTGACAAGAATATTGTACTGTTAGACGATGAAGAAGACGACAAGCCAAAGACCGCTGGAACGTGGAAACAAGACAGCAAGGGGTGGTGGTTCAGACGAAACAATGGCAGTTTCCCTTATAATAAATGGGAAAAAATCGGTGGTGTGTGGTACTACTTCGATAGTAAAGGATATTGCTTAACGAGCGAATGGCTCAAAGATAATGAAAAATGGTACTACCTCAAGGACAACGGCGCAATGGCGACTGGTTGGGTGCTAGTCGGGTCAGAGTGGTATTATATGGACGATTCAGGCGCTATGGTTACTGGTTGGGTCAAGTATAAGAATAACTGGTACTATATGACAAATGAACGTGGTAACATGGTTTCTAATGAATTTATTAAGTCTGGAAAAGGTTGGTATTTCATGAACACAAACGGAGAGCTTGCAGACAATCCAAGTTTCACGAAAGAACCAGACGGGCTTATAACCGTAGCATAA

Genbank protein accession

AAA32204.1 [NCBI]

Genbank nucleotide accession

J03586 [NCBI]

CDS location

range 316 -> 1335
strand +

CDS

ATGGTTAAAAAGAATGATTTATTTGTAGATGTTTCAAGTCACAACGGTTACGATATAACAGGTATCTTGGAGCAAATGGGAACAACTAACACCATCATTAAAATTTCTGAAAGTACGACCTATTTAAACCGTTGCTTGTCTGCTCAAGTGGAGCAGTCAAACCCTATTGGCTTTTATCACTTCGCACGCTTTGGCGGAGACGTAGCAGAAGCCGAAAGAGAAGCGCAGTTTTTCCTTGACAACGTGCCTATGCAAGTTAAATACCTTGTATTGGACTACGAGGACGACCCAAGCGGAGACGCACAAGCGAACACTAACGCATGCTTACGCTTTATGCAGATGATTGCTGACGCTGGATATAAACCTATTTATTATAGTTATAAACCGTTTACACATGATAATGTGGACTATCAGCAAATCCTTGCACAGTTCCCTAATTCTCTATGGATTGCAGGCTATGGCTTAAACGATGGTACAGCTAACTTTGAATACTTCCCAAGCATGGACGGGATAAGATGGTGGCAGTATTCTAGTAACCCGTTTGACAAGAATATTGTACTGTTAGACGATGAAGAAGACGACAAGCCAAAGACCGCTGGAACGTGGAAACAAGACAGCAAGGGGTGGTGGTTCAGACGAAACAATGGCAGTTTCCCTTATAATAAATGGGAAAAAATCGGTGGTGTGTGGTACTACTTCGATAGTAAAGGATATTGCTTAACGAGCGAATGGCTCAAAGATAATGAAAAATGGTACTACCTCAAGGACAACGGCGCAATGGCGACTGGTTGGGTGCTAGTCGGGTCAGAGTGGTATTATATGGACGATTCAGGCGCTATGGTTACTGGTTGGGTCAAGTATAAGAATAACTGGTACTATATGACAAATGAACGTGGTAACATGGTTTCTAATGAATTTATTAAGTCTGGAAAAGGTTGGTATTTCATGAACACAAACGGAGAGCTTGCAGACAATCCAAGTTTCACGAAAGAACCAGACGGGCTTATAACCGTAGCATAA

Gene Ontology

	Description	Category	Evidence (source)
GO:0003796	lysozyme activity	Molecular function	Inferred from Electronic Annotation (UniProt)
GO:0009253	peptidoglycan catabolic process	Biological process	Inferred from Electronic Annotation (InterPro)
GO:0016998	cell wall macromolecule catabolic process	Biological process	Inferred from Electronic Annotation (InterPro)
GO:0042742	defense response to bacterium	Biological process	Inferred from Electronic Annotation (UniProt)
GO:0044659	viral release from host cell by cytolysis	Biological process	Inferred from Electronic Annotation (InterPro)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID: 2J8G

Method: X-ray crystallography

Resolution: 1.69

Chain position: A

View on RCSB