Protein

UniProt accession
O80064 [UniProt]
Protein name
N-acetylmuramoyl-L-alanine amidase
PhaLP type
endolysin

evidence: GO annotation

probability: 99 % (predicted by ML model)

Protein sequence
MLITKNQAEKWFDNSLGKQFNPDLFYGFQCYDYASMFFMIATGERLQGLYAYNIPFDNKARIEKYGQIIKNYDSFLPQKLDIVVFPSKYGGGAGHVEIVESANLNTFTSFGQNWNGKGWTNGVAQPGWGPETVTRHVHYYDDPMYFIRLNFPDKVSVGDKAKSVIKQATAKKQAVIKPKKIMLVAGHGYNDPGAVGNGTNERDFIRKYITPNIAKYLRHAGHEVALYGGSSQSQDMYQDTAYGVNVGNNKDYGLYWVKSQGYDIVLEIHLDAAGESASGGHVIISSQFNADTIDKSIQDVIKNNLGQIRGVTPRNDLLNVNVSAEININYRLSELGFITNKKDMDWIKKNYDLYSKLIAGAIHGKPIGGLVAGNVKTSAKNQKNPPVPAGYTLDKNNVPYKKEAGNYTVANVKGNNVRDGYSTNSRITGVLPNNATIKYDGAYCINGYRWITYIANSGQRRYIATGEVDKAGNRISSFGKFSAV
Physico‐chemical
properties
protein length:484 AA
molecular weight:53685,00000 Da
isoelectric point:9,28617
aromaticity:0,11777
hydropathy:-0,46364

Domains

Domains [InterPro]
IPR003646
404–471
IPR003646 IPR050695
IPR038765
22–158
IPR038765 IPR002508 IPR003646
IPR007921
26–113
IPR007921 IPR002508
IPR007921
5–148
IPR007921 IPR002508
Protein sequence: O80064
1 484
Legend: Pfam SMART CDD TIGRFAM HAMAP SUPFAM PRINTS Gene3D PANTHER Other

Taxonomy

  Name Taxonomy ID Lineage
Phage Staphylococcus phage PVL
[NCBI] 		71366 Peeveelvirus > Peeveelvirus PVL
Host Staphylococcus aureus
[NCBI] 		1280 Bacteria > Firmicutes > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Coding sequence (CDS)

Coding sequence (CDS)
Genbank protein accession
BAA31898.1 [NCBI]
Genbank nucleotide accession
AB009866 [NCBI]
CDS location
range 20199 -> 21653
strand +
CDS
ATGTTGATAACAAAAAACCAAGCAGAAAAATGGTTTGATAATTCATTAGGGAAGCAGTTCAATCCTGATTTGTTTTATGGATTTCAGTGTTACGATTACGCAAGTATGTTTTTTATGATAGCAACAGGCGAAAGGTTACAAGGTTTATACGCTTATAATATTCCATTTGATAATAAAGCAAGGATTGAAAAATACGGGCAAATAATTAAAAACTATGATAGCTTTTTACCGCAAAAGTTGGACATTGTCGTTTTCCCGTCAAAGTATGGTGGCGGAGCTGGACATGTTGAAATTGTTGAGAGCGCTAATCTAAACACTTTCACATCGTTTGGCCAAAATTGGAATGGTAAAGGTTGGACAAATGGCGTTGCGCAACCTGGTTGGGGTCCCGAAACCGTTACAAGACATGTTCATTATTACGATGACCCAATGTATTTTATTAGATTAAATTTCCCAGATAAAGTAAGTGTTGGAGATAAAGCTAAAAGCGTTATTAAGCAAGCAACTGCCAAAAAGCAAGCAGTAATTAAACCTAAAAAAATTATGCTTGTAGCCGGTCATGGTTATAACGATCCTGGAGCAGTCGGAAACGGAACAAATGAACGTGATTTTATCCGTAAATATATAACACCAAATATCGCTAAGTATTTAAGACATGCAGGTCACGAAGTTGCATTATATGGTGGCTCAAGTCAATCACAAGATATGTATCAAGATACTGCTTACGGTGTTAATGTAGGAAATAATAAAGATTATGGCTTATATTGGGTTAAATCACAGGGGTATGACATTGTTCTAGAGATTCATTTAGACGCAGCAGGAGAAAGTGCAAGTGGTGGGCATGTTATTATTTCAAGTCAATTCAATGCAGATACTATTGATAAAAGTATACAAGATGTTATTAAAAATAACTTAGGACAAATAAGAGGTGTAACACCTCGTAATGATTTACTGAACGTTAATGTATCAGCAGAAATAAATATCAATTATCGTTTATCTGAATTAGGTTTTATTACTAATAAAAAAGATATGGATTGGATTAAGAAGAATTATGACTTGTATTCTAAATTAATAGCTGGTGCGATTCATGGTAAGCCTATAGGTGGTTTGGTAGCTGGTAATGTTAAAACATCAGCTAAAAACCAAAAAAATCCACCAGTGCCAGCAGGTTATACACTTGATAAGAATAATGTGCCTTATAAAAAAGAGGCTGGTAATTACACAGTTGCCAATGTTAAAGGTAATAACGTAAGGGACGGCTATTCAACTAATTCAAGAATTACTGGTGTATTACCTAATAACGCAACAATCAAATATGACGGCGCATATTGTATCAATGGCTATAGATGGATTACTTATATCGCTAATAGTGGACAACGTCGTTATATCGCGACAGGAGAGGTAGATAAAGCAGGTAATAGGATAAGTAGTTTTGGTAAGTTTAGCGCAGTTTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell Biological process Inferred from Electronic Annotation (InterPro)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity Molecular function Inferred from Electronic Annotation (UniProt)
GO:0009253 peptidoglycan catabolic process Biological process Inferred from Electronic Annotation (InterPro)
GO:0071555 cell wall organization Biological process Inferred from Electronic Annotation (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 N-acetylmuramoyl-L-alanine amidase residues in certain cell-wall glycopeptides
Hydrolases
Acting on carbon-nitrogen bonds, other than peptide bonds
In linear amides
 match to sequence model evidence used in automatic assertion
ECO:0000256 		ARBA:ARBA00001561

Tertiary structure

No tertiary structures available.