Protein

UniProt accession
G8I4E0 [UniProt]
Protein name
N-acetylmuramoyl-L-alanine amidase
PhaLP type
endolysin

evidence: GO annotation

probability: 99 % (predicted by ML model)

Protein sequence
MMLTVESFAAAMGNSLSVDRYRQLFPAAVESMVACGCTTVNRAAMWLAQVGHESGGLRWMEELASGAAYEWRSDLGNTQAGDGVRFKGRGPIQITGRYNYRKVSEWAHAQGIVPTPTYFVDNPTQLASDQYGFIGVSWYWQHGGPRPGQINGFADAGDILSGSRCVNGWVTTPNGMPDRTERWNRCRAMGDQILPAGAGTDNGGDGMAWTGDPVWLEDVLRPVLGDRLRVLPSWQMYGHGDFKDIRGVMVHHTGNARETAESIRKGRPDLRGPLSNIHIAPDGTVTLVAAGVCWHAGAGSYPWLPTNNANWHMIGIECAWPTIRPNGTYDEREPWPDAQIIAMRDTCAALTKRLGWDASRVIGHKEYAGASQGKWDPGNLDMGWFRGEVAKAMRGEFDPKAPAPAPNPPADNDNGGFLMALNDKQQHDLYNAVMTIAAVAADIQTQLRGPGLRGWPQLGRNANGEALTLVDAVGVIKAIADREAGR
Physico‐chemical
properties
protein length:486 AA
molecular weight:52845,00000 Da
isoelectric point:6,14062
aromaticity:0,08642
hydropathy:-0,39362

Domains

Domains [InterPro]
IPR036505
225–394
IPR036505 IPR023346
IPR036505
227–394
IPR036505
IPR002502
245–380
IPR002502
IPR051206
243–392
IPR051206
IPR002502
243–379
IPR002502
IPR002502
233–378
IPR002502
Protein sequence: G8I4E0
1 486
Legend: Pfam SMART CDD TIGRFAM HAMAP SUPFAM PRINTS Gene3D PANTHER Other

Taxonomy

  Name Taxonomy ID Lineage
Phage Mycobacterium phage DS6A
[NCBI] 		45764 Hnatkovirus > Hnatkovirus DS6A
Host Mycobacterium tuberculosis
[NCBI] 		1773 Bacteria > Actinobacteria > Actinobacteria > Corynebacteriales > Mycobacteriaceae > Mycobacterium

Coding sequence (CDS)

Coding sequence (CDS)
Genbank protein accession
AER47584.1 [NCBI]
Genbank nucleotide accession
JN698994 [NCBI]
CDS location
range 25294 -> 26754
strand +
CDS
GTGATGCTGACGGTTGAATCGTTCGCCGCCGCAATGGGAAACAGCCTGTCAGTGGACCGCTACCGGCAACTGTTCCCGGCTGCGGTGGAGTCGATGGTGGCGTGCGGTTGCACGACGGTCAACCGGGCCGCCATGTGGCTCGCCCAGGTTGGACACGAGTCGGGCGGGCTGCGGTGGATGGAAGAACTAGCGTCCGGTGCTGCCTACGAGTGGCGCTCCGACCTCGGGAATACGCAGGCCGGCGACGGGGTGCGGTTCAAGGGGCGCGGCCCTATCCAAATCACCGGCCGCTACAACTACCGCAAGGTATCGGAGTGGGCGCACGCGCAGGGGATCGTGCCGACGCCAACGTATTTCGTGGACAACCCCACTCAGCTCGCCAGCGACCAATACGGATTTATCGGCGTGTCCTGGTACTGGCAACACGGCGGCCCGCGGCCCGGACAAATCAACGGGTTCGCCGACGCCGGCGACATCCTGTCCGGGTCCCGCTGTGTCAACGGGTGGGTGACTACGCCCAACGGGATGCCCGACCGAACGGAGCGGTGGAACCGCTGCCGCGCAATGGGAGACCAGATTTTGCCGGCAGGGGCCGGCACCGACAACGGGGGTGATGGCATGGCCTGGACCGGGGACCCGGTGTGGCTCGAGGACGTGTTACGGCCGGTGCTCGGCGACCGGCTGCGGGTGCTGCCATCGTGGCAGATGTACGGGCACGGAGACTTCAAGGACATTCGCGGGGTGATGGTTCACCACACCGGCAACGCCCGCGAAACAGCCGAGTCGATCCGCAAGGGCCGCCCCGATCTGCGGGGGCCACTGTCGAATATCCACATCGCACCGGACGGCACCGTGACGCTGGTGGCGGCCGGGGTGTGCTGGCACGCCGGCGCCGGTTCCTACCCGTGGCTGCCGACGAACAACGCCAACTGGCACATGATCGGCATTGAGTGCGCGTGGCCGACGATCCGACCGAACGGCACCTACGACGAGCGCGAGCCGTGGCCCGACGCGCAGATCATCGCCATGCGTGACACCTGCGCCGCGTTGACCAAGCGGCTGGGGTGGGATGCCTCGCGGGTGATCGGACACAAAGAATACGCGGGCGCGTCCCAGGGCAAGTGGGACCCGGGCAACCTCGATATGGGCTGGTTCCGTGGCGAAGTGGCGAAGGCGATGCGCGGCGAGTTCGACCCAAAAGCACCTGCGCCGGCGCCTAACCCGCCGGCAGACAACGACAACGGGGGATTTCTCATGGCATTGAACGATAAGCAACAGCACGACCTGTACAACGCGGTGATGACTATTGCCGCGGTAGCGGCCGACATTCAGACGCAGCTCCGCGGCCCCGGACTGCGCGGGTGGCCGCAGTTGGGGCGCAACGCCAACGGCGAGGCGCTGACCCTCGTTGACGCGGTGGGCGTCATCAAGGCGATCGCCGACCGTGAGGCGGGCCGCTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell Biological process Inferred from Electronic Annotation (InterPro)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity Molecular function Inferred from Electronic Annotation (UniProt)
GO:0009253 peptidoglycan catabolic process Biological process Inferred from Electronic Annotation (InterPro)
GO:0009254 peptidoglycan turnover Biological process Inferred from Electronic Annotation (TreeGrafter)
GO:0042742 defense response to bacterium Biological process Inferred from Electronic Annotation (UniProt)
GO:0071555 cell wall organization Biological process Inferred from Electronic Annotation (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 N-acetylmuramoyl-L-alanine amidase residues in certain cell-wall glycopeptides
Hydrolases
Acting on carbon-nitrogen bonds, other than peptide bonds
In linear amides
 match to sequence model evidence used in automatic assertion
ECO:0000256 		ARBA:ARBA00001561

Tertiary structure

No tertiary structures available.