Protein

UniProt accession

A8WA19 [UniProt]

Protein name

Lysin A

PhaLP type

endolysin

evidence: GO annotation

probability: 99 % (predicted by ML model)

Protein sequence

MPVYAIQSGTVIYAGAASGYGGPDPAGWLVIDSDDAEGGGCLEYGHIVREVNRGDHVTAGQRIGHINPNNRTNGGVAPHLHVTDWPHAYGQGSRQNVMARLSGAREPEAQAAPTPTEQGTVVGDPVWLADVVRPTVAKFAEYPGWRNRGHGDFKDIRGVMVHHTGGPASAASIANGRPDLAGPLAQLHISRDGTVTVVAVGVAWHAGAGSYPWLPTNMGNWHLIGIECEWPYGEPGINERNAYTVRWRDPEIIALRNTCAAILLRLGLGVDRLIGHKDYAGRAQGKWDPGNMSMDWLRGEVRKDMDGFVFPGEDIVNVTPPPVPAPVPAPPATANVLLHRGMSGPNVVKLQTTLRRWYSKLAVDGDFGPHTEACVRDRQRIYGLDVDGIVGPLTAAKIGLVL

Physico‐chemical properties

protein length:	402 AA
molecular weight:	43082,00000 Da
isoelectric point:	6,42488
aromaticity:	0,07214
hydropathy:	-0,25448

Domains

Domains [InterPro]

IPR036505

135–306

IPR036505 IPR036365 IPR011055

IPR002502

144–290

IPR002502 IPR036366 IPR011055

IPR016047

2–82

IPR016047 IPR002502 IPR002477

IPR036505

136–308

IPR036505

Protein sequence: A8WA19

1 402

Legend: Pfam SMART CDD TIGRFAM HAMAP SUPFAM PRINTS Gene3D PANTHER Other

Domains [InterPro]

InterPro ID	Start	End	Source	Name
IPR036505	135	306	Gene3D	N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily
IPR036365	330	399	SUPFAM	PGBD-like superfamily
IPR002502	144	290	CDD	N-acetylmuramoyl-L-alanine amidase domain
IPR036366	332	400	Gene3D	PGBD superfamily
IPR011055	1	93	SUPFAM	Duplicated hybrid motif
IPR011055	2	82	SUPFAM	Duplicated hybrid motif
IPR016047	2	82	Pfam	Peptidase M23
IPR002502	154	291	CDD	N-acetylmuramoyl-L-alanine amidase domain
IPR002477	343	397	Pfam	Peptidoglycan binding-like
IPR036505	136	308	Gene3D	N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily

Taxonomy

	Name	Taxonomy ID	Lineage
Phage	Mycobacterium phage Giles [NCBI]	480808	Gilesvirus > Gilesvirus giles
Host	Mycobacterium smegmatis [NCBI]	1772	Bacteria > Actinobacteria > Actinobacteria > Corynebacteriales > Mycobacteriaceae > Mycobacterium

Coding sequence (CDS)

Genbank protein accession

ABW88426.1 [NCBI]

Genbank nucleotide accession

EU203571 [NCBI]

CDS location

range 27131 -> 28339
strand +

CDS

ATGCCGGTGTACGCCATCCAATCCGGCACCGTCATCTATGCGGGCGCGGCGTCCGGCTACGGCGGCCCCGATCCGGCCGGTTGGCTGGTCATCGACAGTGACGACGCCGAAGGCGGCGGGTGCCTCGAATACGGCCACATCGTGCGCGAAGTGAACCGCGGCGACCACGTCACCGCCGGGCAGCGCATCGGCCACATCAACCCGAACAACCGCACCAACGGCGGCGTCGCGCCTCACCTACACGTGACCGATTGGCCGCACGCATACGGCCAGGGATCCCGACAGAACGTCATGGCACGTCTGTCCGGTGCGCGTGAACCGGAGGCGCAGGCCGCGCCGACACCAACAGAACAGGGGACCGTGGTGGGCGATCCAGTGTGGCTGGCCGATGTCGTACGACCGACCGTTGCGAAGTTCGCCGAATACCCGGGGTGGCGCAACCGCGGGCATGGCGACTTCAAAGACATTCGCGGCGTCATGGTGCACCACACCGGCGGCCCGGCGTCGGCGGCGTCCATCGCCAACGGGCGGCCGGATTTGGCGGGGCCGCTGGCGCAACTTCACATCTCCCGCGACGGCACCGTGACCGTGGTGGCGGTCGGTGTCGCGTGGCACGCCGGGGCCGGGTCGTACCCGTGGTTGCCCACGAATATGGGCAACTGGCATCTGATCGGCATCGAGTGCGAATGGCCGTACGGCGAACCCGGCATCAACGAACGCAACGCGTACACCGTCCGGTGGCGCGACCCGGAAATCATCGCCCTACGCAACACGTGCGCCGCGATCCTGCTTCGGCTGGGGTTGGGCGTCGACCGGTTGATCGGACACAAAGACTACGCGGGGCGCGCCCAGGGTAAATGGGATCCCGGCAACATGTCGATGGATTGGCTACGCGGCGAAGTCCGCAAGGACATGGACGGGTTCGTGTTCCCGGGCGAAGACATCGTGAACGTCACGCCGCCGCCGGTGCCCGCGCCGGTGCCCGCGCCTCCGGCCACGGCCAACGTGCTGTTGCACCGCGGGATGTCCGGCCCGAACGTCGTGAAGCTGCAAACGACGTTGCGCCGGTGGTACTCGAAGTTGGCCGTGGATGGCGACTTCGGTCCGCACACCGAAGCGTGCGTGCGTGACCGGCAGCGTATCTACGGCCTCGATGTCGACGGCATCGTGGGTCCGCTCACGGCCGCGAAGATTGGGTTGGTGCTCTGA

Gene Ontology

	Description	Category	Evidence (source)
GO:0001897	symbiont-mediated cytolysis of host cell	Biological process	Inferred from Electronic Annotation (InterPro)
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Molecular function	Inferred from Electronic Annotation (UniProt)
GO:0009253	peptidoglycan catabolic process	Biological process	Inferred from Electronic Annotation (InterPro)
GO:0042742	defense response to bacterium	Biological process	Inferred from Electronic Annotation (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available.