Protein

UniProt accession

A1BU77 [UniProt]

Protein name

Phage amidase

PhaLP type

endolysin

evidence: GO annotation

probability: 99 % (predicted by ML model)

Protein sequence

MTNKTRSQAHAYLDRLKGYWWDFDGVYGAQCFDLANQYWYYVTGRTLSGMYAKDIPFVNDFNGYANVVKNYNSYIPKKGTLVVFPYEYGNGCGHVAIIESATQNYFYSLDQNWYGGARNNPPEVAQTIYHEYHPDMYFVEPLYSKETKVSKIKAKTTKPKPVKKVKKRKVMIVAGHGYNDPGAIGNGYNERDFIRKNIVDNVSKYLKDAGHTVGIYGKKQDMYQDTAYGVRVGNHRDYGLYWVKSQGYDTVIEFHLDSAGPKATGGHTIIPAGYPANIIDKNIQEALKQSVGVIRGITQRNDLLNCNVANDIGIDYRLVELGFITSYKDMKYINKNIKPFTKSIASAINGKPIGGTSAGKVKSVKKTWDWKGRFYPNTTIKVRKKPNGEIVEKGSWLYGKDDWVDIVQLYKDTKKKLWWGKFKYPTNPSSGYFYCALGEITDKQERIKKEKKLYGKIKWK

Physico‐chemical properties

protein length:	460 AA
molecular weight:	52620,00000 Da
isoelectric point:	9,54301
aromaticity:	0,14130
hydropathy:	-0,65391

Domains

Domains [InterPro]

IPR002508

171–349

IPR002508 IPR007921

IPR038765

12–147

IPR038765 IPR002508

IPR007921

24–112

IPR007921 IPR002508

IPR050695

127–348

IPR050695

Protein sequence: A1BU77

1 460

Legend: Pfam SMART CDD TIGRFAM HAMAP SUPFAM PRINTS Gene3D PANTHER Other

Domains [InterPro]

InterPro ID	Start	End	Source	Name
IPR002508	171	349	Pfam	N-acetylmuramoyl-L-alanine amidase, catalytic domain
IPR007921	6	140	Pfam	CHAP domain
IPR038765	12	147	SUPFAM	Papain-like cysteine peptidase superfamily
IPR007921	24	112	Pfam	CHAP domain
IPR002508	170	349	Pfam	N-acetylmuramoyl-L-alanine amidase, catalytic domain
IPR002508	243	349	Pfam	N-acetylmuramoyl-L-alanine amidase, catalytic domain
IPR050695	127	348	PANTHER	N-acetylmuramoyl-L-alanine amidase 3

Taxonomy

	Name	Taxonomy ID	Lineage
Phage	Rockefellervirus PH15 [NCBI]	399185	Rockefellervirus >
Host	Staphylococcus epidermidis [NCBI]	1282	Bacteria > Firmicutes > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Coding sequence (CDS)

Genbank protein accession

ABI21810.1 [NCBI]

Genbank nucleotide accession

DQ834250 [NCBI]

CDS location

range 24765 -> 26147
strand +

CDS

ATGACAAACAAAACGAGAAGTCAAGCACATGCCTATTTAGACAGGTTGAAAGGTTATTGGTGGGATTTCGACGGTGTTTATGGCGCACAATGTTTCGATTTAGCCAATCAATATTGGTACTACGTAACAGGTCGTACTTTGAGTGGTATGTACGCTAAAGATATACCTTTTGTCAATGATTTTAATGGATACGCGAATGTTGTAAAAAATTATAATTCTTACATTCCTAAAAAAGGTACTTTAGTTGTTTTTCCTTACGAGTATGGTAATGGATGTGGTCACGTTGCTATTATAGAAAGTGCTACTCAAAATTATTTCTATAGTTTGGATCAAAATTGGTATGGTGGTGCAAGAAATAATCCGCCAGAGGTCGCTCAAACAATATACCACGAATATCACCCTGATATGTATTTTGTAGAACCTCTGTACTCTAAAGAAACAAAGGTAAGTAAAATTAAAGCAAAAACAACTAAACCTAAACCTGTGAAAAAAGTTAAAAAAAGAAAAGTGATGATCGTTGCTGGTCATGGGTATAATGATCCTGGTGCTATTGGTAACGGTTATAACGAACGTGATTTTATAAGAAAAAACATTGTTGATAATGTATCAAAATATTTGAAAGACGCAGGTCATACTGTTGGTATATATGGAAAAAAACAAGATATGTATCAAGATACAGCTTACGGAGTGAGAGTAGGTAATCACAGAGATTATGGCTTATATTGGGTAAAATCTCAAGGGTATGATACCGTTATTGAATTTCATTTAGATAGCGCAGGTCCTAAAGCTACAGGTGGACATACTATAATACCTGCTGGTTATCCTGCTAATATAATAGACAAAAACATTCAAGAGGCATTAAAACAAAGCGTCGGTGTTATAAGAGGGATAACTCAACGTAACGACTTATTAAACTGTAACGTCGCTAATGATATTGGTATAGATTATAGACTTGTTGAATTGGGCTTCATTACTTCATATAAAGATATGAAGTATATTAATAAAAATATAAAACCTTTCACAAAGTCAATAGCAAGCGCTATTAATGGCAAGCCAATCGGAGGAACAAGTGCCGGTAAAGTTAAAAGTGTAAAAAAAACATGGGATTGGAAAGGTAGATTTTATCCGAACACAACAATTAAAGTCAGAAAAAAACCAAACGGTGAAATTGTAGAAAAAGGTTCTTGGTTGTACGGAAAAGACGATTGGGTAGATATTGTTCAATTATACAAAGACACTAAGAAAAAATTATGGTGGGGTAAATTTAAATACCCGACTAATCCTAGTTCTGGTTATTTTTATTGCGCTTTGGGTGAAATTACTGACAAACAAGAACGGATAAAAAAAGAGAAGAAATTATATGGAAAGATAAAGTGGAAATAA

Gene Ontology

	Description	Category	Evidence (source)
GO:0001897	symbiont-mediated cytolysis of host cell	Biological process	Inferred from Electronic Annotation (InterPro)
GO:0008745	N-acetylmuramoyl-L-alanine amidase activity	Molecular function	Inferred from Electronic Annotation (UniProt)
GO:0009253	peptidoglycan catabolic process	Biological process	Inferred from Electronic Annotation (InterPro)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available.