Protein

UniProt accession

A0A088FS70 [UniProt]

Protein name

Baseplate central spike protein

PhaLP type

endolysin

evidence: UniProt function annotation

probability: 99 % (predicted by ML model)

Protein sequence

MEMISSSLNWFVGVVEDRMDPLKQGRVRVRVVGLHPAQRAQGDVQGIPTEKLPWMTVIQPITSASISGIGGSVTGPVEGTRVYGHFLDKWKTNGIVLGTYGGIVREKPNRLEGFSDPTGQYPRRLGNDTNVLNQGGEAGYYSNSNVIQDNNLDYGINPDDTDLANIPEDDDPNFTITEMLRRDEGLRDKVYWDHLGYPTVGIGHLIVMEKTRDMSRINKLLSDQVGREVTGNPGTITLEEATALFEKDLAKMQKDIRSNSKVGPVYAKMNRSRQMALENMCFQMGVGGVAKFNTMLKAMAAGDWKTAYKSGRDSLWFQQTKGRASRVTTIILTGNMESYGVPVKTPPSPGVGADLVTRNTDPEDPASPPVPLDSRILFKEPESSYRGEYPYVHAMETESGHIQEFDDTPGNERYRLVHPTGSYEEVSPSGRRTRKTVEDLFDITNGDGNFLISGDKLVNVGANEIYYNMADRLHQIDGSDTIFIRGNQTKTVEGDGTLYVKGNIKIVVDGNADILVKGDAKTQVEGNHDYTVNGNVKWTVNGNVDMTVAGNWSETMTTMSSIASGQYTVDGSRIDIG

Physico‐chemical properties

protein length:	577 AA
molecular weight:	63514,00000 Da
isoelectric point:	5,22580
aromaticity:	0,07279
hydropathy:	-0,52894

Domains

Domains [InterPro]

IPR052619

175–338

IPR052619 IPR009590 IPR010609

IPR023346

130–342

IPR023346

IPR001165

250–270

IPR001165

IPR023347

177–342

IPR023347

IPR002196

183–309

IPR002196

IPR046397

3–577

IPR046397

Protein sequence: A0A088FS70

1 577

Legend: Pfam SMART CDD TIGRFAM HAMAP SUPFAM PRINTS Gene3D PANTHER Other

Domains [InterPro]

InterPro ID	Start	End	Source	Name
IPR052619	175	338	PANTHER	Bacteriophage lysozyme-like
IPR023346	130	342	SUPFAM	Lysozyme-like domain superfamily
IPR001165	250	270	PRINTS	T4-type lysozyme
IPR009590	33	173	Pfam	Protein Gp5, N-terminal OB-fold domain
IPR023347	177	342	Gene3D	Lysozyme domain superfamily
IPR010609	534	556	Pfam	Gp5, C-terminal
IPR002196	183	309	Pfam	Glycoside hydrolase, family 24
IPR046397	3	577	HAMAP	Pre-baseplate central spike protein Gp5

Taxonomy

	Name	Taxonomy ID	Lineage
Phage	Shigella phage Shf125875 [NCBI]	1541825	Straboviridae > Mosigvirus > Mosigvirus utam
Host	Shigella flexneri [NCBI]	623	Bacteria > Proteobacteria > Gammaproteobacteria > Enterobacteriales > Enterobacteriaceae > Shigella

Coding sequence (CDS)

Genbank protein accession

AIM50737.1 [NCBI]

Genbank nucleotide accession

KM407600 [NCBI]

CDS location

range 80698 -> 82431
strand +

CDS

ATGGAAATGATTAGCAGTAGCCTTAATTGGTTCGTGGGTGTTGTTGAGGACAGAATGGACCCATTAAAACAAGGGCGAGTTCGAGTTCGAGTCGTTGGTCTTCATCCAGCACAGAGAGCACAAGGTGATGTACAAGGTATTCCTACAGAAAAACTTCCGTGGATGACTGTTATTCAACCTATTACGTCTGCATCAATTTCAGGTATTGGTGGTTCTGTTACAGGTCCTGTTGAAGGAACTCGAGTATACGGTCATTTCTTAGACAAATGGAAAACAAACGGGATAGTACTTGGTACATACGGCGGAATCGTACGTGAAAAGCCTAATAGACTTGAAGGTTTTTCAGACCCGACTGGCCAATATCCGCGACGTTTAGGTAATGATACGAACGTATTAAACCAAGGTGGTGAAGCTGGTTATTATTCAAACTCTAACGTAATTCAAGATAACAACTTGGATTATGGTATAAACCCAGATGATACAGATTTGGCAAATATTCCAGAAGATGATGACCCTAATTTTACAATAACAGAAATGTTACGTCGTGACGAAGGACTTCGTGATAAAGTGTATTGGGACCATCTAGGGTATCCTACAGTAGGTATTGGACACCTTATCGTAATGGAAAAGACCCGAGATATGTCTCGAATTAATAAATTGTTATCTGATCAAGTAGGGCGTGAAGTAACAGGAAATCCAGGGACTATTACATTAGAAGAAGCAACAGCGTTATTTGAGAAAGACCTTGCTAAGATGCAGAAAGATATTCGTTCTAATTCTAAAGTAGGTCCTGTTTATGCCAAAATGAATAGGTCTCGCCAAATGGCATTAGAAAACATGTGCTTCCAAATGGGTGTTGGCGGTGTAGCAAAATTCAATACTATGCTTAAAGCAATGGCCGCAGGCGATTGGAAAACTGCATACAAATCTGGGCGTGATTCGTTATGGTTCCAACAGACTAAAGGACGTGCTTCACGCGTAACAACAATTATTTTAACTGGTAACATGGAATCATACGGTGTTCCTGTTAAAACACCACCTTCGCCTGGTGTTGGTGCCGATTTAGTTACTAGAAATACAGATCCAGAAGATCCGGCTAGTCCTCCTGTTCCATTAGATTCACGTATCCTTTTTAAAGAACCGGAATCAAGTTATCGTGGTGAATACCCGTATGTTCATGCTATGGAAACAGAAAGCGGACATATCCAAGAGTTTGACGACACTCCAGGTAATGAACGTTATCGCTTAGTTCATCCGACAGGGTCATATGAGGAAGTTTCTCCATCCGGTCGTCGTACTCGTAAAACTGTAGAAGACCTTTTTGACATCACTAATGGCGATGGGAACTTCTTGATTTCTGGTGATAAACTTGTTAACGTTGGTGCTAATGAAATATATTATAACATGGCAGACCGCCTCCATCAAATAGATGGCAGCGACACAATCTTTATTCGTGGTAACCAAACTAAAACTGTTGAAGGCGATGGAACTCTTTACGTTAAGGGCAATATTAAAATAGTTGTTGACGGAAATGCAGATATTCTTGTTAAAGGTGATGCTAAGACTCAAGTTGAAGGGAATCATGACTATACTGTCAATGGTAATGTTAAATGGACTGTCAATGGTAATGTTGATATGACTGTTGCTGGCAATTGGTCTGAGACAATGACTACAATGAGCTCAATAGCTTCAGGACAATATACTGTTGACGGATCTCGTATTGATATTGGGTAA

Gene Ontology

	Description	Category	Evidence (source)
GO:0003796	lysozyme activity	Molecular function	Inferred from Electronic Annotation (UniProt)
GO:0009253	peptidoglycan catabolic process	Biological process	Inferred from Electronic Annotation (InterPro)
GO:0016998	cell wall macromolecule catabolic process	Biological process	Inferred from Electronic Annotation (InterPro)
GO:0031640	killing of cells of another organism	Biological process	Inferred from Electronic Annotation (UniProt)
GO:0042742	defense response to bacterium	Biological process	Inferred from Electronic Annotation (UniProt)
GO:0098003	viral tail assembly	Biological process	Inferred from Electronic Annotation (UniProt)
GO:0098025	virus tail, baseplate	Cellular component	Inferred from Electronic Annotation (UniProt)
GO:0098932	symbiont entry into host cell via disruption of host cell wall peptidoglycan	Biological process	Inferred from Electronic Annotation (UniProt)
GO:0098994	symbiont entry into host cell via disruption of host cell envelope	Biological process	Inferred from Electronic Annotation (UniProt)

Enzymatic activity

EC Number	Entry Name	Reaction Catalyzed	Classification	Evidence	Source
3.2.1.17	lysozyme aka muramidase	D-glucosamine residues in chitodextrins	Hydrolases Glycosylases Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds	match to sequence model evidence used in automatic assertion ECO:0000256	HAMAP-Rule:MF_04151

Tertiary structure

No tertiary structures available.