Protein

UniProt accession

A0A060BN52 [UniProt]

Protein name

Baseplate central spike protein

PhaLP type

endolysin

evidence: UniProt function annotation

probability: 99 % (predicted by ML model)

Protein sequence

MDPLKQGRVRVRVVGLHPAQRTQGDVQGIPTEKLPWMTVIQPITSASMSGIGGSVTGPVEGTRVYGHFLDKWKTNGIVLGTYGGIVREKPNRLEGFSDPTGQYPRRLGNDTNVLNQGGEAGYYSNSNVIQDNNLDYGINPDDTDLANIPEDDDPNFTITEMLRRDEGLRDKVYWDHLGYPTVGIGHLIVMEKTRDMSRINKLLSDQVGREVTGNPGTITLEEATALFEKDLAKMQKDIRSNSKVGPVYAKMNRSRQMALENMCFQMGVGGVAKFNTMLKAMATGDWKTAYKSGRDSLWFQQTKGRASRVTTIILTGNMESYGVPVKTPPSPGVGADLVTRNTDPEDPAGPPVPLDSRILFKEPESSYRGEYPYVHAMETESGHIQEFDDTPGNERYRLVHPTGSYEEVSPSGRRTRKTVEDLFDITNGDGNFLISGDKLVNVGANEIYYNMADRLHQIDGNDTIFIRGNQSKTVEGDGTLYVKGNIKIVVDGNADILVKGDAKTQVEGNHDYTVNGNVKWTVNGNVDMTVAGDWAETMSTMSSVASGQYTVDGSRIDIG

Physico‐chemical properties

protein length:	559 AA
molecular weight:	61451,00000 Da
isoelectric point:	5,26849
aromaticity:	0,07156
hydropathy:	-0,56941

Domains

Domains [InterPro]

IPR002196

165–291

IPR002196 IPR010609 IPR009590

IPR023347

159–324

IPR023347

IPR052619

157–320

IPR052619

IPR001165

179–197

IPR001165

IPR023346

112–324

IPR023346

IPR046397

1–559

IPR046397

Protein sequence: A0A060BN52

1 559

Legend: Pfam SMART CDD TIGRFAM HAMAP SUPFAM PRINTS Gene3D PANTHER Other

Domains [InterPro]

InterPro ID	Start	End	Source	Name
IPR002196	165	291	Pfam	Glycoside hydrolase, family 24
IPR023347	159	324	Gene3D	Lysozyme domain superfamily
IPR052619	157	320	PANTHER	Bacteriophage lysozyme-like
IPR010609	516	538	Pfam	Gp5, C-terminal
IPR001165	179	197	PRINTS	T4-type lysozyme
IPR023346	112	324	SUPFAM	Lysozyme-like domain superfamily
IPR009590	15	155	Pfam	Protein Gp5, N-terminal OB-fold domain
IPR046397	1	559	HAMAP	Pre-baseplate central spike protein Gp5

Taxonomy

	Name	Taxonomy ID	Lineage
Phage	Escherichia phage vB_EcoM_JS09 [NCBI]	1430444	Straboviridae > Mosigvirus > Mosigvirus JS09
Host	Escherichia coli B [NCBI]	37762	Bacteria > Proteobacteria > Gammaproteobacteria > Enterobacteriales > Enterobacteriaceae > Escherichia
Host	Escherichia coli [NCBI]	562	Bacteria > Proteobacteria > Gammaproteobacteria > Enterobacteriales > Enterobacteriaceae > Escherichia

Coding sequence (CDS)

Genbank protein accession

AIA79969.1 [NCBI]

Genbank nucleotide accession

KF582788 [NCBI]

CDS location

range 88243 -> 89922
strand -

CDS

ATGGACCCGTTAAAACAAGGGCGAGTTCGAGTTCGAGTCGTTGGTCTTCATCCAGCGCAGAGAACACAAGGTGATGTACAAGGTATTCCTACAGAAAAACTTCCATGGATGACTGTTATTCAACCTATTACGTCTGCATCAATGTCAGGTATTGGTGGTTCTGTTACAGGTCCTGTTGAAGGAACTCGAGTATATGGTCATTTCTTAGACAAATGGAAAACAAACGGGATTGTACTTGGTACATACGGCGGAATAGTACGTGAAAAGCCTAATAGACTTGAAGGTTTTTCAGACCCGACAGGCCAGTATCCGCGACGTTTAGGTAATGATACGAACGTACTAAACCAAGGTGGTGAAGCTGGTTATTATTCGAACTCTAACGTAATTCAAGATAACAACTTGGATTATGGTATAAACCCAGATGATACAGATTTAGCAAATATTCCAGAAGATGATGACCCTAATTTTACAATAACAGAAATGTTACGTCGTGACGAAGGTCTTCGTGATAAAGTGTATTGGGACCATCTCGGGTATCCTACAGTAGGTATTGGACACCTTATCGTAATGGAAAAGACCAGAGATATGTCTCGAATTAATAAATTGTTATCTGATCAAGTAGGGCGTGAAGTAACAGGAAATCCGGGAACTATTACATTAGAAGAAGCAACAGCGTTATTTGAGAAGGACCTTGCTAAGATGCAGAAAGACATTCGTTCTAATTCTAAAGTAGGTCCTGTTTATGCTAAAATGAACAGATCTCGCCAAATGGCATTAGAAAACATGTGCTTCCAGATGGGCGTCGGCGGTGTAGCAAAATTCAATACTATGCTTAAAGCAATGGCCACAGGTGATTGGAAAACCGCATACAAATCTGGGCGTGATTCGTTATGGTTCCAACAGACTAAAGGGCGTGCTTCACGTGTAACAACAATTATTTTAACTGGTAACATGGAATCATATGGCGTTCCTGTTAAAACACCACCTTCACCAGGAGTTGGTGCCGATTTAGTTACTAGAAATACTGATCCAGAAGACCCAGCTGGTCCTCCTGTTCCGTTAGATTCACGTATCCTTTTTAAAGAACCTGAATCAAGTTATCGTGGTGAGTATCCATACGTTCATGCTATGGAAACGGAAAGCGGTCATATCCAAGAATTTGACGATACTCCAGGTAATGAACGTTATCGCTTAGTTCATCCAACAGGGTCATATGAGGAAGTTTCTCCGTCTGGGCGTCGTACTCGTAAAACTGTAGAAGACCTTTTTGACATCACTAATGGCGATGGGAACTTCTTGATTTCCGGTGATAAACTTGTTAACGTTGGTGCTAATGAAATATATTATAACATGGCAGACCGCCTCCATCAAATAGACGGCAATGATACAATCTTTATTCGTGGTAACCAATCTAAAACTGTTGAAGGCGATGGAACTCTTTACGTTAAGGGTAATATCAAAATAGTCGTTGACGGAAATGCGGATATTCTTGTTAAAGGTGATGCTAAAACTCAGGTCGAAGGGAATCATGATTACACCGTCAACGGAAACGTCAAATGGACTGTTAATGGTAATGTTGATATGACTGTTGCTGGGGATTGGGCAGAAACAATGTCTACAATGAGCTCAGTAGCTTCAGGACAATACACTGTTGACGGATCTCGTATTGATATTGGGTAA

Gene Ontology

	Description	Category	Evidence (source)
GO:0003796	lysozyme activity	Molecular function	Inferred from Electronic Annotation (UniProt)
GO:0009253	peptidoglycan catabolic process	Biological process	Inferred from Electronic Annotation (InterPro)
GO:0016998	cell wall macromolecule catabolic process	Biological process	Inferred from Electronic Annotation (InterPro)
GO:0031640	killing of cells of another organism	Biological process	Inferred from Electronic Annotation (UniProt)
GO:0042742	defense response to bacterium	Biological process	Inferred from Electronic Annotation (UniProt)
GO:0098003	viral tail assembly	Biological process	Inferred from Electronic Annotation (UniProt)
GO:0098025	virus tail, baseplate	Cellular component	Inferred from Electronic Annotation (UniProt)
GO:0098932	symbiont entry into host cell via disruption of host cell wall peptidoglycan	Biological process	Inferred from Electronic Annotation (UniProt)
GO:0098994	symbiont entry into host cell via disruption of host cell envelope	Biological process	Inferred from Electronic Annotation (UniProt)

Enzymatic activity

EC Number	Entry Name	Reaction Catalyzed	Classification	Evidence	Source
3.2.1.17	lysozyme aka muramidase	D-glucosamine residues in chitodextrins	Hydrolases Glycosylases Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds	match to sequence model evidence used in automatic assertion ECO:0000256	HAMAP-Rule:MF_04151

Tertiary structure

No tertiary structures available.