Protein

Protein accession
H7BVK7 [UniProt]
Representative
62PL1
Source
UniProt (cluster: phalp2_8073)
Protein name
N-acetylmuramoyl-L-alanine amidase domain-containing protein
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKYSKSNPPMTCMMTQSTCYKGTKKMTVKGVLWHSTGANNPTLKRYVQPDDGAPDRAELLSKLGTNANKNDWNHIDTQAGLNAWIGKLADGSVAAVQTMPWDFRPWGCGSGSKGSCNSGWIQFEICEDALTDADYFAAVYQEACELTAYLCTLYGIDPKGTADCSGVTVPTILCHADSHKLKLGSNHADVTHWFPKFGKSMETARDDVAALMSGSTAPGTEDKTAIMGKAQATASQMAAFCLSKNASPQLPSCTVEGLARMFIEEGEAEGVRGDVAFAQSLHETGYFKFGGIVLPSQNNYAGIGALNGNATGQAASFPDPRTGVRAQIQHLKAYASTEALVNACVDPRFSLVARGVAPYVEWLGAADNPQGRGWAVPGAGYGANVVKLLGQILAFQDPGDGYPANTPEWQKAGFEALVERGIINSPDVWKAKFDQPIKVGEILAIIGRM
Physico‐chemical
properties
protein length:449 AA
molecular weight:47907,7 Da
isoelectric point:5,94
hydropathy:-0,23
Representative Protein Details
Accession
62PL1
Protein name
62PL1
Sequence length
241 AA
Molecular weight
25991,10910 Da
Isoelectric point
6,97462
Sequence
MKYSKSNPPMTCMMTQSTCYKGTKKMTVKGVLWHSTGANNPTLKRYVQPDDGAPDRAELLSKLGTNANKNDWNHIDTQAGLNAWIGKLADGSVAAVQTMPWDFRPWGCGSGSKGSCNSGWIQFEICEDALTDADYFAAVYQEACELTAYLCTLYGIDPKGTADCSGVTVPTILCHADSHKLKLGSNHADVTHWFPKFGKSMETARDDVAALMSGSTAPGTEDKTAIMGKAQATASQMRRSA
Other Proteins in cluster: phalp2_8073
Total (incl. this protein): 35 Avg length: 282,2 Avg pI: 7,70
Protein ID Length (AA) pI
62PL1 241 6,97462
21gHy 300 9,06917
24Luu 222 7,99880
2bWKb 275 9,30893
2olln 296 8,54981
3PIqK 267 8,91464
3TG1a 267 8,86700
3TQUO 311 6,54242
3ZGPn 283 8,87686
3ZU0v 304 9,33723
3ZZKH 302 9,24343
3dNPa 211 5,94981
3dO8T 308 8,48290
3dRhJ 295 9,07285
3dVvk 263 5,76736
3del1 312 6,54856
3ikwu 273 8,75669
3ir5f 283 9,08961
3nFji 266 9,32002
3nXZu 374 8,01756
3vlNl 273 9,16632
3xXPB 295 4,79780
45v3o 266 9,02262
4SL3a 316 5,84756
4UUJ7 181 8,10279
4k6nV 262 5,22449
4k7uz 247 5,17590
4kiTC 220 7,56563
5D5n 276 8,78815
607Ej 255 5,80567
7w5mb 292 8,48186
85Wvw 301 5,35698
o63k 297 8,03342
orvl 295 7,65760
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_25741
4Lci3
 6 73,9% 215 2.618E-123
2 phalp2_36672
45lpM
 229 48,3% 209 1.702E-83
3 phalp2_39111
2nYlj
 83 45,7% 225 5.995E-83
4 phalp2_35488
tqvH
 739 50,2% 211 1.731E-80
5 phalp2_34904
4jM8q
 3 45,8% 181 9.839E-63
6 phalp2_17257
3WAN9
 1 36,6% 210 2.740E-48
7 phalp2_24341
3TP9g
 1 26,2% 232 5.621E-46
8 phalp2_11707
21AlC
 5 33,0% 212 5.489E-43
9 phalp2_32070
5P7Lm
 156 32,1% 230 1.524E-40
10 phalp2_23011
3Pylt
 316 31,0% 222 1.301E-36

Domains

Domains [InterPro]
Ami2
Disordered region
Representative sequence (used for alignment): 62PL1 (241 AA)
Member sequence: H7BVK7 (449 AA)
1 241 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Bacteriophage sp
[NCBI] 		38018 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
JQ680365 [NCBI]
CDS location
range 10152 -> 11501
strand +
CDS
ATGAAGTACAGCAAAAGCAACCCGCCCATGACGTGCATGATGACACAAAGCACTTGCTACAAGGGCACCAAGAAGATGACGGTCAAGGGCGTCTTGTGGCACAGCACCGGGGCGAACAACCCGACCCTCAAGCGATATGTTCAGCCGGACGACGGCGCACCCGACCGAGCCGAGCTCCTGTCCAAGCTGGGCACCAACGCGAACAAGAACGACTGGAACCACATCGACACACAAGCGGGCCTGAACGCCTGGATCGGGAAGCTCGCGGACGGGAGCGTCGCGGCGGTTCAGACGATGCCCTGGGACTTTAGGCCGTGGGGATGTGGGAGCGGCAGCAAGGGGTCATGCAACAGCGGATGGATTCAGTTTGAAATCTGTGAGGACGCCTTGACGGACGCCGACTACTTCGCCGCCGTGTATCAAGAGGCGTGTGAGCTGACGGCGTACCTCTGCACCCTCTACGGCATCGACCCCAAAGGAACCGCCGATTGCTCCGGCGTCACTGTCCCGACCATTTTGTGCCACGCGGACAGCCACAAACTAAAGCTCGGCAGCAATCACGCCGACGTGACACACTGGTTCCCCAAGTTCGGGAAGTCGATGGAGACCGCCCGGGACGATGTCGCGGCCCTGATGAGCGGCTCCACCGCGCCGGGCACGGAAGACAAGACGGCGATCATGGGCAAGGCCCAGGCCACCGCGTCGCAGATGGCGGCGTTCTGCTTGAGCAAGAACGCCTCGCCGCAGCTCCCGAGCTGCACCGTGGAGGGGCTGGCCCGCATGTTCATCGAGGAGGGCGAGGCCGAGGGCGTCCGGGGCGACGTGGCCTTCGCGCAGAGCCTCCACGAAACGGGCTATTTTAAGTTCGGCGGGATCGTCCTTCCGTCTCAAAATAACTATGCCGGGATCGGGGCCCTCAACGGCAACGCCACGGGACAGGCGGCGAGCTTCCCCGACCCGCGCACGGGCGTCCGGGCGCAGATCCAGCACCTCAAGGCATACGCATCCACCGAGGCCCTCGTGAACGCTTGCGTCGACCCCCGCTTCTCCCTGGTCGCCCGTGGCGTGGCCCCCTATGTGGAATGGCTGGGCGCGGCGGACAACCCGCAGGGGCGCGGCTGGGCGGTTCCCGGCGCGGGCTACGGGGCGAACGTCGTGAAGCTGCTCGGCCAGATCCTCGCCTTCCAAGACCCGGGGGACGGCTACCCGGCCAATACCCCGGAATGGCAAAAGGCGGGCTTTGAGGCCCTGGTAGAGCGCGGCATCATCAACTCCCCGGACGTGTGGAAGGCGAAGTTCGACCAACCGATCAAGGTCGGGGAAATCCTGGCGATCATCGGCAGGATGTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0004040 amidase activity molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi00025171dd_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (62PL1) rather than this protein.
PDB ID
62PL1
Method AlphaFoldv2
Resolution 91.48
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50