Protein

Protein accession
E0Y3M7 [UniProt]
Representative
73AW6
Source
UniProt (cluster: phalp2_14804)
Protein name
Cell wall hydrolase
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MGLPNPKTRKPTASEVVEWALYIAKKKIAIDVPGSGMGAQCWDLPNYLLDKYWGFRTWGNADAMAQKSNYRGRDFKIIRNTKDFVPQPGDWGVWTGGWAGHVNIVVGPCTKDYWYGVDQNWYTNNATGSPPYKIKHSYHDGPGGGVKYFVRPPYHPEKSTPAPKPEDDSDDNEKNNKKVPIWKDVTTIKYTISSQEVNYPEYIYHFIVEGNRRLEKPKGIMIRNAQTMSSVESLYNSRKKYKQDVEYPHFYVDRHNIWAPRRAVFEVPNEADYIVIDVCEDYSASKNEFIFNEIHAMVVAVDMMIKYEIPLSIENLKVDDSIWRSMLEHVNWNMIDNGVPPKDKYEALEKALLNIFKNREKLLNSITKPTVTKSRIKVMVDNKNADIANVRDSSPTANNGSASKQPQIITETSPYTFKQALDKQMARGNPKKSNAWGWANATRAQTSSAMNVKRIWESNTQCYQMLNLGKYQGVSVSALNKILKGKGTLNNQGKAFAEACKKHNINEIYLIAHAFLESGYGTSNFANGKDGVYNYFGIGAYDNNPNYAMTFARNKGWTSPAKAIMGGASFVRKDYINKGQNTLYRIRWNPKNPATHQYATAIEWCQHQASTIAKLYKQIGLKGIYFTRDKYK
Physico‐chemical
properties
protein length:632 AA
molecular weight:72018,8 Da
isoelectric point:9,39
hydropathy:-0,68
Representative Protein Details
Accession
73AW6
Protein name
73AW6
Sequence length
184 AA
Molecular weight
20829,22680 Da
Isoelectric point
9,05312
Sequence
MGLPNPKNRKPTASEVVEWALYIAKNKIAIDVPGSGMGAQCWDLPNYLLDKYWGFRTWGNADAMAQKSNYRGRDFKIIRNTKDFVPQPGDWGVWTGGWAGHVNIVVGPCTKDYWYGVDQNWYTNNATGSPPYKIKHSYHDGPGGGVKYFVRPPYHPEKSTPAPKPEDDSDDNEKIIKKFQFGKM
Other Proteins in cluster: phalp2_14804
Total (incl. this protein): 35 Avg length: 546,2 Avg pI: 9,38
Protein ID Length (AA) pI
73AW6 184 9,05312
75Bjk 186 10,33842
7a2Y9 286 8,81832
7k8ND 184 9,28404
7lQyW 145 8,94223
7ogAv 199 9,17819
7zGgS 237 9,62199
Q4ZDD0 632 9,39441
E9LT62 632 9,39951
S4V9N2 632 9,41949
A0A0F6N4K6 632 9,41949
Q4ZDK5 632 9,34677
A0A3G1LEC2 632 9,41949
A0A513ZXY9 632 9,36863
A0A6B7H5U4 632 9,41949
A0A6C0RUV3 632 9,41949
A0EX80 632 9,38945
A1KX46 632 9,39441
I1W630 632 9,39951
Q4ZDT5 632 9,37359
Q8SDT1 632 9,37359
S4SVK1 632 9,41949
S4SXB3 632 9,41949
A0A2Z5HS34 632 9,37359
A0A899IPU2 632 9,37359
A0A976SFL7 632 9,39441
A0AAX3C8M9 632 9,39441
A0AAX3C8V8 632 9,41440
A0AAX3C922 632 9,41949
A0EWN1 632 9,37359
A0EWU7 632 9,37359
A4ZFD3 632 9,34677
B2ZZ02 632 9,41949
Q8LTH4 632 9,37353
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_568
Omza
 65 31,9% 144 1.362E-24
2 phalp2_25333
7ocj2
 56 33,9% 156 9.597E-22
3 phalp2_10799
3WA57
 47 32,8% 146 5.147E-17
4 phalp2_27772
7kL3N
 52 30,5% 154 2.426E-16
5 phalp2_5002
1dLD0
 578 26,3% 167 4.661E-14
6 phalp2_8656
45aVs
 41 32,2% 152 1.176E-13
7 phalp2_13870
7vCZb
 24 28,2% 138 1.382E-12
8 phalp2_368
7aJP9
 3 29,4% 136 1.613E-11
9 phalp2_24452
4BMZo
 66 31,1% 138 7.467E-11
10 phalp2_35756
4f4tw
 5 26,4% 117 3.951E-09

Domains

Domains [InterPro]
Unannotated
Disordered region
Representative sequence (used for alignment): 73AW6 (184 AA)
Member sequence: E0Y3M7 (632 AA)
1 184 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage Dubowvirus SAP26
[NCBI] 		872294 Dubowvirus >
Host Staphylococcus aureus
[NCBI] 		1280 Firmicutes > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
GU477322 [NCBI]
CDS location
range 18117 -> 20015
strand +
CDS
ATGGGATTACCTAATCCAAAGACTCGAAAACCTACAGCTAGTGAAGTAGTAGAGTGGGCGTTGTATATTGCTAAAAAGAAAATAGCTATTGATGTACCCGGTTCTGGAATGGGGGCGCAATGTTGGGACTTGCCTAATTACTTGCTTGATAAATATTGGGGGTTTAGAACATGGGGAAATGCTGATGCTATGGCTCAGAAATCTAATTATAGAGGTAGAGATTTCAAGATAATTAGAAATACAAAAGATTTTGTACCACAACCAGGCGACTGGGGTGTTTGGACTGGTGGTTGGGCAGGACATGTAAACATTGTAGTGGGACCATGCACAAAAGACTATTGGTATGGCGTAGATCAAAACTGGTATACAAATAACGCAACAGGAAGTCCGCCATATAAAATTAAGCACTCTTATCATGATGGACCAGGTGGAGGAGTTAAATATTTTGTTAGACCACCATATCATCCGGAGAAATCTACGCCGGCACCTAAACCCGAAGATGATAGTGATGATAACGAAAAAAATAATAAAAAAGTTCCAATTTGGAAAGATGTAACAACTATAAAGTACACAATTTCTAGCCAAGAAGTTAATTATCCAGAATATATTTATCACTTTATAGTAGAGGGTAATCGACGACTCGAAAAACCTAAAGGGATAATGATTAGAAACGCTCAAACAATGAGCTCGGTAGAAAGTTTATATAACAGTAGAAAGAAATATAAGCAAGATGTAGAATATCCACACTTTTATGTTGATAGACATAATATTTGGGCTCCTAGAAGAGCCGTATTTGAAGTTCCTAATGAAGCTGATTATATAGTTATAGACGTATGTGAAGATTATAGTGCGAGTAAAAACGAATTTATTTTTAACGAGATTCACGCAATGGTTGTAGCTGTAGATATGATGATCAAATATGAGATACCTCTAAGTATTGAGAATTTAAAAGTAGACGATAGTATTTGGCGTTCAATGTTGGAACATGTTAATTGGAATATGATTGACAACGGTGTTCCCCCTAAAGATAAATACGAAGCATTAGAAAAGGCATTACTTAATATATTTAAAAACAGAGAAAAATTATTAAATTCTATAACTAAACCAACAGTAACAAAATCTAGAATAAAAGTTATGGTAGATAATAAAAACGCTGATATAGCGAATGTAAGAGACTCATCACCAACAGCTAATAATGGCTCGGCATCTAAACAACCGCAGATCATAACAGAAACGAGTCCTTATACATTCAAACAAGCACTGGATAAACAAATGGCAAGAGGTAACCCGAAAAAATCTAATGCTTGGGGTTGGGCTAACGCTACACGAGCACAAACGAGCTCGGCAATGAATGTTAAACGAATATGGGAAAGTAACACACAGTGCTACCAAATGCTTAATTTAGGCAAGTATCAAGGTGTTTCAGTTAGCGCACTTAATAAGATACTTAAAGGTAAGGGAACATTGAATAATCAAGGTAAAGCGTTCGCAGAAGCTTGTAAAAAACACAACATTAATGAAATTTATTTAATCGCGCATGCTTTCTTAGAAAGTGGATATGGAACAAGTAACTTCGCTAACGGAAAAGATGGAGTATACAACTACTTCGGCATTGGCGCTTACGACAACAATCCTAACTACGCAATGACGTTTGCAAGGAATAAAGGTTGGACATCTCCAGCAAAAGCAATCATGGGCGGTGCTAGCTTCGTAAGAAAGGATTACATCAATAAAGGTCAAAACACATTGTACCGAATTAGATGGAATCCTAAGAATCCAGCTACCCACCAATACGCTACTGCTATAGAGTGGTGCCAACATCAAGCAAGTACAATCGCTAAGTTATATAAACAAATCGGCTTAAAAGGTATCTACTTCACAAGGGATAAATATAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0004040 amidase activity molecular function None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi0001e13ab3_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (73AW6) rather than this protein.
PDB ID
73AW6
Method AlphaFoldv2
Resolution 90.25
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50