Protein

Protein accession
A0AAX4Q6W4 [UniProt]
Representative
2lm87
Source
UniProt (cluster: phalp2_19389)
Protein name
Peptidase M23 domain-containing protein
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MGLKYKITSGFHSKEPFRDHLHNGVDLKMAEGTDLRAIADGTIRVADYGNTNAGKTVFIDAADGKTYIYGHLSDFSVSNGQTIHAGELIGHSGNSGFSTGPHLHFGIKEDGQYLDPTPYVQLLQDMNKGLKEAAHSSMNNGLSALDMLNEALSKFSETLSEMTLNVIVNLEPAIHRGLQVLDLVLSLIC
Physico‐chemical
properties
protein length:189 AA
molecular weight:20457,8 Da
isoelectric point:5,60
hydropathy:-0,18
Representative Protein Details
Accession
2lm87
Protein name
2lm87
Sequence length
189 AA
Molecular weight
20633,19180 Da
Isoelectric point
4,82918
Sequence
MKFVITSPFGAHESFRNHAHNGIDIRMEEGTPLSAIKDGVIRIANYEDANAGKTIFLEMEDGTTAIYGHLSEFIARNGDKVQAGDLIGYSGNTGFSTGEHLHFAIKDNGAFVDPTSFVDQVQQTGLLQWFLDRGAIDSFDPIIGNLPDLLIGVGVDAIMWVGILFLLFFNKYTRNFTVGAAILMILFGG
Other Proteins in cluster: phalp2_19389
Total (incl. this protein): 43 Avg length: 187,2 Avg pI: 5,64
Protein ID Length (AA) pI
2lm87 189 4,82918
A0A0A0PUM0 182 6,10925
A0A0Y0AH42 194 5,54165
A0A142F145 204 5,17499
A0A076G6R1 182 6,48893
L0LC03 182 5,85552
U5PY92 186 5,67318
A0A384X998 189 5,50795
S6B1Q4 186 5,25888
R4JF21 189 5,87825
A0A345MK47 163 5,10723
A0A516KNM9 186 5,73985
A0A7S5SKR9 183 5,78555
A0A7T7ZCC7 189 5,69148
A0A7T8C462 189 5,69148
A0A7T8C4I6 189 5,69148
A0A7U3TFF3 189 5,69148
A0A9X9H1Z8 186 5,69432
A0AA96KRD6 182 6,10925
A0AAE7V9X4 192 5,73991
A0AAE7VAN9 192 5,88036
A0AAE7WYJ0 186 5,49988
A0AAE7WZ22 186 5,59412
A0AAE7WZ40 186 5,62890
A0AAE8BND7 186 5,59412
A0AAE8BQ10 186 5,59412
A0AAE9H2C5 190 5,28457
A0AAE9H2H3 190 5,41428
A0AAE9H360 190 5,28457
A0AAE9H443 190 5,28457
A0AAE9H4Y9 189 5,54319
A0AAE9KL14 190 5,28457
A0AAE9KMB2 186 5,71319
A0AAE9YEH2 184 5,87291
A0AAE9YF83 186 5,73985
A0AAE9YMS4 183 5,59702
A0AAF0C0U8 186 5,73985
A0AAN0LQ21 192 6,34269
A0AAX4NSC9 186 5,69432
A0AAX4Q4V1 189 5,59696
A0AAX4Q633 189 5,73707
A0AAX4Q778 189 5,73707
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_20625
4LnEC
 5 39,3% 122 1.092E-26
2 phalp2_18623
3ebV
 83 40,0% 125 6.854E-23
3 phalp2_3247
2k2so
 54 40,4% 126 4.449E-22
4 phalp2_35838
4GGll
 4 40,4% 131 1.547E-21
5 phalp2_21998
4ZChj
 22 35,7% 126 3.938E-21
6 phalp2_25537
3nGXJ
 39 33,5% 143 3.478E-20
7 phalp2_22730
8dH10
 29 37,9% 137 8.841E-20
8 phalp2_27996
15l2O
 11 38,2% 115 1.206E-19
9 phalp2_14848
7w0BH
 74 35,2% 136 2.246E-19
10 phalp2_22862
2DiVF
 1 37,6% 117 1.448E-18

Domains

Domains [InterPro]
PET_M23
Representative sequence (used for alignment): 2lm87 (189 AA)
Member sequence: A0AAX4Q6W4 (189 AA)
1 189 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01551

Taxonomy

  Name Taxonomy ID Lineage
Phage Bacillus phage KKP_4048
[NCBI] 		3109401 Herelleviridae > Siophivirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
PP579743 [NCBI]
CDS location
range 23930 -> 24499
strand -
CDS
GTGGGGTTGAAATACAAGATCACTTCCGGGTTTCACAGCAAAGAGCCGTTTAGAGATCATCTTCATAACGGAGTTGATTTGAAGATGGCCGAAGGGACTGATCTTAGAGCAATTGCAGACGGTACAATTCGTGTAGCCGACTATGGAAATACGAACGCAGGAAAAACGGTGTTCATAGATGCGGCCGATGGTAAAACCTACATCTATGGACACCTCTCGGACTTTTCGGTGAGTAACGGCCAAACCATACACGCTGGAGAATTAATAGGACACTCAGGGAACAGCGGTTTTAGTACTGGACCACATTTGCACTTTGGCATAAAAGAGGATGGTCAATATTTAGACCCAACACCTTACGTACAGCTTCTTCAAGATATGAATAAGGGTTTAAAGGAGGCAGCGCATTCAAGTATGAACAACGGACTAAGTGCACTAGATATGTTGAACGAAGCGCTGAGTAAGTTTTCAGAAACGTTATCGGAAATGACACTTAATGTGATTGTCAATCTAGAACCCGCCATTCATAGAGGGCTTCAAGTATTAGATTTAGTTCTTTCATTGATATGTTGA

Gene Ontology

Description Category Evidence (source)
GO:0004222 metalloendopeptidase activity molecular function None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (2lm87) rather than this protein.
PDB ID
2lm87
Method AlphaFoldv2
Resolution 78.73
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50