Protein

Protein accession
A0AAE9V8B2 [UniProt]
Representative
7bpzP
Source
UniProt (cluster: phalp2_38184)
Protein name
N-acetylmuramoyl-L-alanine amidase domain-containing protein
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MQYINKSVCRGVAGRRAKGWKPDGIVIHNDGGSMTPEAYVSWLAAKTAQQLQAGFAHYYGNRNQMARVEETYNGAWHVANYYGNMNFVGYEVCESLKVSDADFIANEEAVFEQAAKDLMEWGLPANRNTVKIHRRFVPTSCPHRSWDLHVGKGAPDTDANRGKMEDYFIARIKAYMNGSAKPVEPETPTDVKPDVEKLIGGIGMFIYWQPQAKGNISDAYGVWGNKRFYISNDSKLKHFRALVENATGRPCKEYKTWARGSEQIRVVESFTEEQEGL
Physico‐chemical
properties
protein length:277 AA
molecular weight:31259,8 Da
isoelectric point:8,22
hydropathy:-0,61
Representative Protein Details
Accession
7bpzP
Protein name
7bpzP
Sequence length
464 AA
Molecular weight
52110,46220 Da
Isoelectric point
8,65864
Sequence
MKKIDGVNWAVKNIGNRLTDGQPYGAQCATFIIEFTKKYWGVHPKGNAKDFINYKWPKEFQVIKGKKQIPQPGDIFVFGGGYGHTGIVTEANGTYFNSIDQNWYNESLTKGSPAAFVEDHEYSNFLGVIRPPYEDAEKGASKKSTKIETINHTINYKMPNRSGNVKGVVIHNTAGNATANQDYNNLRNASVARYEAGIAHYYIDRNTVWRAIDTYSVGWHVANAYGNNAFIGYEVNESMSANNKDFMANEQAVFKKAAADLLYYGLPVNRETVMLHCQFVPTACPHRSMALHTGFDPVRQGAAPTSIVNQLKDYFIKEIKKYYNNPALKAGSPASSDVPDRETIPTEQDKNDFNKESGEKVGNGWRKNKHNILWKPEKATFTCKALDSEGNRSFIYTRYHGPWTGWEIAGQLQYGQSVNYDEVYDYDGYIWIAWTVNSGARVYMPIGNSNGNGSRVGDAWGNFS
Other Proteins in cluster: phalp2_38184
Total (incl. this protein): 284 Avg length: 467,3 Avg pI: 8,98
Protein ID Length (AA) pI
7bpzP 464 8,65864
1Ms 455 5,58104
1RhF3 463 5,47720
1bCDn 478 9,58395
1bE1V 491 9,50272
1bUzf 479 9,41788
1bvGa 440 9,73075
1bvHn 474 9,69194
1bzKx 470 9,14118
1e86J 488 9,57106
1e901 478 9,00586
1ek7B 493 9,52606
1elaf 493 9,36934
1enlC 478 9,57099
1k5Qj 388 9,68162
1mVjj 487 9,69271
3ATDD 479 9,30674
3e8Dg 457 8,31766
416wb 340 9,77877
4tQnN 455 6,31432
5M9OK 476 9,58369
5MX6s 487 9,63372
5PekH 486 8,03278
5YbzI 487 9,72153
5tqW 487 9,74467
5tyD 487 9,69271
65oBI 486 8,61899
69G6c 487 9,62108
6gis5 486 8,29542
6w5zu 486 8,61899
71IFp 481 8,73252
71K7M 487 9,65138
71Kb0 487 9,70044
729Oy 487 9,63359
72Q1p 487 9,70857
72Q8c 487 9,75460
72UWP 481 8,61905
73O6d 458 8,78925
73pzF 481 8,73252
73yf9 487 9,70850
74dAA 487 9,75982
74dzE 476 9,32627
75Ad8 474 9,66305
75BMn 481 8,47928
75TA5 478 8,93991
762Zd 481 8,73787
76J2g 481 8,73252
76nmK 481 8,61905
77CoA 481 8,82870
77jXm 481 8,61905
77siH 416 9,17187
77x1B 481 8,62937
78AMv 481 8,61409
78FsB 481 8,02910
78Hsi 481 8,61402
78lFO 481 8,62402
78mCH 481 8,82890
78rEL 481 8,61409
78s5F 481 8,82877
78sFJ 481 8,73252
78zt3 481 8,61905
79nZs 477 9,04848
79u4E 481 8,90665
7AZdm 481 9,16645
7AzS0 490 8,61409
7B7P7 490 8,48386
7BBLF 481 8,61899
7BFPQ 477 8,84115
7BHgk 484 8,69706
7BKuu 488 9,19720
7BNmc 484 8,73252
7BNs6 487 9,70844
7Bry9 494 9,61174
7BubR 486 8,62402
7Bz1m 487 9,72475
7C4e8 487 9,70850
7McZT 484 9,52657
7Md5c 340 9,79702
7QiRW 482 9,20501
7QiuD 481 8,72723
7Qk3B 481 8,82316
7RhJa 481 8,61905
7Rjw9 487 9,71643
7RlqW 481 8,29123
7a2CI 493 9,45347
7aEJ6 481 8,72729
7aEuK 481 8,73252
7aIhh 481 8,25339
7aIxL 481 8,90671
7aJJG 481 8,82322
7aJP3 459 9,26702
7aMRK 481 8,48438
7aMSp 481 8,89485
7aMUJ 481 8,63420
7aNdt 481 8,73806
7aOdh 481 8,83444
7aQfl 481 8,82322
7aZTZ 495 9,50304
7ahic 481 8,90677
7akpJ 481 8,82316
7am1a 481 8,47922
7anQV 481 8,61905
7auuI 481 8,61409
7aw5h 481 8,61905
7b4pW 494 9,50304
7bCSj 481 8,83444
7bG08 481 8,83444
7bJEf 481 8,48431
7bKam 481 8,83438
7c4mm 476 9,15917
7cIOH 481 8,77810
7cQAL 481 8,61409
7d4xM 455 5,30157
7d4yQ 478 9,60007
7dM99 481 8,90665
7dk8D 481 8,73252
7dkzp 481 8,72723
7dnMu 481 8,82890
7eA5y 481 8,73252
7ealx 474 9,70966
7f4B3 481 8,73806
7fLLt 487 9,69219
7fu6E 481 8,61899
7gDED 474 9,70941
7gFi6 481 8,47464
7gLFf 487 9,70051
7gOda 481 8,73806
7gPX3 481 9,03584
7gaTG 472 8,70247
7gdCH 481 8,61905
7gfWz 493 9,53367
7gkp1 476 9,33594
7glYm 481 7,59144
7gxDW 481 8,73806
7h0QA 476 9,41414
7h6ql 487 9,61786
7hD96 481 8,73806
7hDlk 481 8,72723
7hd4c 481 8,82877
7htj9 481 8,73252
7hxl0 487 9,54218
7hxmc 488 9,49369
7iD5X 481 8,73780
7imYh 416 9,73423
7jIHh 496 9,54043
7jf92 481 8,61905
7k97M 478 9,63385
7kF0N 481 8,61905
7kS2I 455 6,23623
7kdCR 487 9,74454
7kkJY 481 8,73787
7kyKq 487 9,61683
7l2sO 477 9,36489
7lKGI 459 9,40221
7lRz9 481 8,62402
7lx6y 488 9,31402
7mBV9 488 9,68407
7ogAB 490 9,59188
7ogS6 454 9,88250
7owhj 463 5,19238
7qASW 483 9,24349
7qClq 484 9,21216
7qP5R 463 5,31924
7qPSc 454 9,72791
7qUVE 487 9,72810
7qUWP 454 9,81107
7qZVX 466 7,64697
7qZXU 458 7,64839
7qq6i 474 9,33298
7qq9v 492 9,58073
7qqgw 475 9,35058
7qsB0 455 6,89863
7qsPU 481 9,15485
7qsZm 482 9,18476
7qsuv 481 9,28540
7qsxi 472 8,74180
7qszp 472 8,91251
7qt49 472 8,62808
7qtK8 481 9,13963
7qtN0 485 9,17361
7qtiz 483 9,33904
7qtn0 482 9,23982
7quE1 477 9,34948
7quJc 481 9,22615
7que5 481 9,19140
7queb 482 9,24685
7qufS 481 9,19140
7quqr 482 9,20513
7qutz 482 9,19824
7quw7 485 9,17367
7r99w 476 9,22364
7r9DK 481 9,29255
7r9FD 481 9,04854
7r9ME 477 9,16658
7r9gh 481 9,10315
7r9hv 481 9,13957
7r9jm 477 9,15956
7r9kn 481 9,12139
7rBES 460 8,92031
7rBMn 473 9,69632
7rBOF 473 9,68762
7rBSV 479 9,61109
7rCm5 481 8,72729
7rDMp 481 8,73252
7rEK3 481 8,47471
7rExd 481 8,47877
7rF6V 481 8,25332
7rqCS 493 9,54907
7ry10 455 6,27601
7ry1j 455 8,12213
7ry24 363 6,86788
7ry37 457 8,83141
7ry3h 463 5,58906
7ry7j 455 7,72200
7t5BN 481 8,90684
7tlq1 481 8,29955
7u8ra 481 8,90091
7xxU5 481 8,73265
7yFnv 487 9,66834
7yFpD 481 8,82877
7ycCM 457 8,86152
7ycjW 481 9,44876
7ycjl 454 9,85988
7ycjr 471 9,31389
7zGbI 485 9,00599
7zMbz 495 9,50291
7zo8X 470 9,14718
7zoa3 467 9,06679
7zoa7 459 9,33272
7zocN 458 9,18019
81Tci 470 8,45807
86cr8 493 9,50317
8JNqO 495 9,58891
8JNrC 481 8,73252
8JNrI 481 8,82877
8JNrV 478 9,65248
8JNrc 496 9,50304
8JNs8 495 9,53238
8JNsh 481 8,72729
8JNsi 496 9,61238
8JNsn 487 9,73184
8LLsu 467 9,24543
8LWYo 495 9,47229
8M7ee 474 9,69194
8M8Sb 495 9,50304
8M8hR 428 9,72507
8M9mp 481 8,47928
8MbGW 490 8,61899
8Mkch 487 9,70863
8ftB7 487 9,63385
8ftK7 487 9,70057
8ftpI 477 8,90897
8ftzd 487 9,68484
8t9pn 375 9,49421
NKzJ 487 9,70844
OcM7 434 9,74712
OcMz 488 9,42123
PYqr 475 9,86897
UUhb 455 6,53753
UUi9 457 8,62666
UUjW 455 6,50360
UUlZ 457 6,70623
oPEs 487 9,68433
oqQE 460 8,53157
pLZJ 487 9,69245
pLzo 469 9,77162
pYWz 487 9,62882
qI6E 368 9,63939
wyMQ 448 9,63856
x14C 487 9,71643
ylML 487 9,74132
O56788 467 9,24543
A0A076YNQ2 295 9,38455
A0A6S6MG30 295 9,59968
A0A977XQP8 296 9,63714
A0AAD1KYY0 289 9,59085
A0AAE6LCB5 209 9,92086
A0AAE7FJG8 114 10,15901
A0AAE9V5M2 275 9,05492
A0AAE9V7R0 275 8,84682
A0AAE9VBV1 342 9,80708
A0AAE9VE48 342 9,79405
A0AAF0AC39 342 9,75073
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_15234
UUjd
 13 56,8% 294 4.052E-121
2 phalp2_36222
7r9gE
 32 35,5% 340 4.556E-85
3 phalp2_22245
7e47k
 317 23,8% 524 7.883E-47
4 phalp2_25267
88emb
 10 24,3% 378 1.940E-34
5 phalp2_18764
13cSu
 4 21,9% 310 2.940E-25
6 phalp2_18952
3MmP0
 1 22,2% 512 7.095E-24
7 phalp2_24730
6BIOG
 3 23,1% 316 4.981E-18
8 phalp2_22264
7pxLN
 64 19,1% 350 3.049E-13
9 phalp2_28103
7vQh7
 9 22,4% 316 8.882E-12
10 phalp2_22268
7qxva
 11 20,4% 327 2.259E-08

Domains

Domains [InterPro]
Ami2
SH3_5
Representative sequence (used for alignment): 7bpzP (464 AA)
Member sequence: A0AAE9V8B2 (277 AA)
1 464 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510|PF05257, PF08460

Taxonomy

  Name Taxonomy ID Lineage
Phage Enterococcus phage EC99P1
[NCBI] 		2968637 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OP172782 [NCBI]
CDS location
range 54033 -> 54866
strand +
CDS
ATGCAATACATTAACAAGAGCGTCTGTCGGGGAGTAGCTGGCAGACGTGCTAAAGGATGGAAGCCTGATGGCATTGTCATCCACAATGATGGGGGTTCTATGACTCCCGAAGCCTATGTAAGCTGGCTTGCTGCAAAGACTGCTCAACAGCTTCAAGCAGGTTTCGCTCACTACTATGGCAACCGCAATCAAATGGCTCGTGTGGAAGAAACTTACAACGGAGCTTGGCACGTGGCTAACTACTACGGCAATATGAACTTCGTCGGATATGAGGTTTGCGAATCTCTTAAAGTATCTGATGCAGACTTTATCGCCAACGAGGAAGCGGTATTCGAACAGGCTGCTAAAGACCTTATGGAATGGGGTCTACCAGCTAACCGAAATACTGTTAAGATTCATCGACGCTTCGTTCCTACAAGCTGTCCGCATCGTTCTTGGGACTTGCACGTAGGCAAAGGAGCTCCTGACACAGATGCTAACCGAGGCAAGATGGAAGACTATTTCATCGCTCGTATTAAAGCATACATGAATGGCTCGGCAAAACCTGTCGAACCTGAAACTCCAACAGATGTTAAACCAGATGTTGAAAAACTTATAGGGGGAATTGGAATGTTTATTTATTGGCAACCACAAGCAAAAGGAAATATCTCGGATGCGTATGGAGTGTGGGGTAACAAACGCTTCTACATCTCTAACGACAGCAAGTTGAAACACTTCCGCGCATTGGTGGAAAACGCTACTGGACGACCTTGTAAAGAGTACAAGACATGGGCTCGGGGAAGCGAACAGATTCGTGTGGTAGAAAGCTTCACTGAGGAACAAGAAGGTTTATAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7bpzP) rather than this protein.
PDB ID
7bpzP
Method AlphaFoldv2
Resolution 95.04
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50