Protein

Protein accession
A0AAE9V5P7 [UniProt]
Representative
5Qdvo
Source
UniProt (cluster: phalp2_14663)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MAHLYVIAGHGAGDSGAVGNGYTEAERVRALASKIKQLGGDNVTLGDMNRNYYADNGISSLNIPKDWCIIELHMDSASASARGGHVIIKGTFNPDSHDLALASFVSAMFPGRANSIVGRNNLANPNRAAAKGYNYRLVEFGFISNATDVSIFNSNLDAIARGVLSCFGINTNTAKWVLDNVGWWYQRADGSYPKSQWLLLDCYYYFNDKGYALANERLSYGGNWYWLKDDCRMATGWQYIDKHWYYLNPTGTKNKPVGAMLDGWQFIDGQWYYLRTKADGEHPHGSMVEGSVTVGEHDYYCREAGTDKNYPTGSMLMGWRKVTETAEDGTKKTKWFWYNKDSNCQPIGSMLKNHWLTTSNGKKYYLKDDGVMACDETMTISGKEYTFDASGALV
Physico‐chemical
properties
protein length:394 AA
molecular weight:44000,7 Da
isoelectric point:6,55
hydropathy:-0,48
Representative Protein Details
Accession
5Qdvo
Protein name
5Qdvo
Sequence length
180 AA
Molecular weight
19287,21940 Da
Isoelectric point
6,90965
Sequence
MAHLFLIAGHGAGDSGAVGYGFTEAERVRALASRIVAYGGSNVTLGDTSRNWYADRGITSLNIPKDWQILELHMDSGSASAKGGHVIIKQGYNPDQYDTALANFIGSFFPGRANKIVGRANLANVNRSATKGYSYRLLENGFISNKDDLTKFNNQIDDLARGILNAFGIATASPAKEDSD
Other Proteins in cluster: phalp2_14663
Total (incl. this protein): 48 Avg length: 218,7 Avg pI: 7,13
Protein ID Length (AA) pI
5Qdvo 180 6,90965
1EnTy 223 6,59903
23DJ3 131 9,02997
24lG4 238 8,73510
3GQS2 271 5,30424
3WKlr 209 8,68255
3m8LD 103 5,07768
3mxBO 239 5,96249
3pN82 162 9,29919
3sA4E 145 5,40234
3tjMV 161 8,92521
3ufjh 203 9,26025
3wbnY 224 5,84034
4NKER 312 9,69671
4Vtne 165 6,88874
4tQbN 227 9,28488
5NsjM 168 6,39611
5RXE3 221 5,45890
5Ta3W 199 5,69807
5W9QH 144 7,66925
5WmxX 118 4,46433
602p4 217 6,03553
65dw0 221 5,17698
66kYY 195 9,22757
6iCGf 221 5,17698
6rBxC 134 9,47358
6sHH4 216 4,57232
6unAB 221 4,96013
75vIo 255 9,45173
75xOT 179 6,30989
7W2CB 241 6,15301
7ctcV 172 7,73274
7qBOf 163 9,18566
7ujhH 253 5,75088
7xRyn 305 9,60709
802R2 132 7,77196
8IFbT 293 9,82448
8ewaj 218 6,07861
8jGmd 218 7,66732
aOJc 222 8,35241
nKrm 207 7,70347
nXBA 115 8,29349
oTPk 209 5,84199
A0A8S5SBY6 270 5,51238
A0AAE9V4S2 394 6,55168
A0AAE9V5Z5 394 6,55168
A0AAF0AAX3 394 6,36417
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_30582
5VNAp
 1 40,5% 170 4.092E-45
2 phalp2_24034
84xVV
 39 28,7% 191 5.218E-38
3 phalp2_8361
n723
 104 28,2% 170 9.787E-38
4 phalp2_3696
51zXL
 234 25,8% 174 2.139E-21
5 phalp2_3137
88Bj8
 3 24,1% 186 5.852E-19
6 phalp2_6374
7yZe6
 41 24,3% 185 1.091E-18
7 phalp2_14862
15a1
 46 26,2% 179 9.626E-18
8 phalp2_19469
366PJ
 1 30,1% 156 9.626E-18
9 phalp2_24413
4m1OU
 1246 27,5% 189 2.150E-16
10 phalp2_22723
7Z7VD
 14 23,1% 186 2.933E-16

Domains

Domains [InterPro]
Ami3
Representative sequence (used for alignment): 5Qdvo (180 AA)
Member sequence: A0AAE9V5P7 (394 AA)
1 180 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01520

Taxonomy

  Name Taxonomy ID Lineage
Phage Clostridium phage CS266P2
[NCBI] 		2968623 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OP172776 [NCBI]
CDS location
range 8903 -> 10087
strand -
CDS
ATGGCACATTTATATGTGATTGCAGGACATGGTGCAGGGGATTCTGGTGCAGTTGGGAATGGATATACCGAAGCAGAAAGAGTTCGTGCATTAGCAAGTAAAATCAAACAGTTAGGGGGAGACAATGTTACACTTGGGGATATGAACAGAAATTATTATGCGGACAATGGTATTAGTTCTCTGAACATTCCGAAAGATTGGTGTATCATTGAGTTGCACATGGACAGCGCTTCTGCAAGTGCTAGGGGCGGTCATGTGATTATCAAGGGAACATTTAATCCAGATTCGCATGACCTTGCGCTCGCTAGTTTTGTTAGTGCAATGTTCCCCGGAAGGGCAAACAGTATTGTTGGAAGAAACAACCTTGCAAACCCGAATAGGGCGGCGGCAAAGGGATATAATTACAGATTGGTAGAATTTGGTTTCATTTCAAATGCAACGGATGTATCAATCTTTAATAGTAATCTGGATGCGATTGCGAGGGGTGTTCTGTCATGTTTCGGAATCAATACGAACACAGCAAAATGGGTACTTGACAATGTTGGCTGGTGGTATCAGAGAGCAGACGGAAGTTATCCGAAATCACAGTGGCTTCTGTTGGATTGCTATTACTATTTCAATGACAAAGGATATGCACTTGCAAATGAGCGGTTAAGTTATGGCGGCAATTGGTATTGGCTGAAAGATGATTGCAGAATGGCGACAGGATGGCAGTACATTGATAAACATTGGTATTATCTGAACCCGACAGGGACAAAGAACAAACCAGTTGGTGCAATGTTGGATGGCTGGCAGTTCATTGATGGACAATGGTACTATCTTAGAACAAAAGCAGATGGAGAACATCCGCATGGTTCGATGGTTGAAGGTTCTGTTACAGTTGGAGAACATGACTATTATTGCAGAGAAGCAGGAACAGACAAGAACTATCCGACAGGCAGTATGTTGATGGGATGGAGAAAGGTAACAGAAACAGCAGAAGATGGAACAAAGAAAACAAAATGGTTCTGGTATAACAAAGACAGCAATTGTCAACCTATCGGAAGTATGTTAAAGAATCATTGGCTTACAACATCAAATGGCAAAAAGTATTACTTAAAAGATGATGGTGTTATGGCTTGTGATGAAACAATGACAATCAGCGGAAAAGAATACACATTCGATGCAAGCGGAGCATTGGTATAA

Gene Ontology

Description Category Evidence (source)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016798 hydrolase activity, acting on glycosyl bonds molecular function None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. N/A UniProt

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (5Qdvo) rather than this protein.
PDB ID
5Qdvo
Method AlphaFoldv2
Resolution 96.00
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50