Protein

Protein accession
A0AAE8Y7D2 [UniProt]
Representative
8MT9Q
Source
UniProt (cluster: phalp2_23662)
Protein name
Lysin A, N-acetylmuramoyl-L-alanine amidase domain
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MVESSITRTQISPNKHYGGRDVDWVVIHTQEGNGRARDIIPFLCNPASEVSYNAVVDDVESVLVVPWDANPWAAMNANTRGDHLLSAGSFAKWSKAKWLEIDARDGKNENAQMDRLALLTAWRCKVRGIPPVYVGGKGRPSKPGICGHVDFGAWGGGHTDPGPNFPWIEFISRVQGFYYGEDFDMAAKDEVIDFIKGFVGPIVSDVKDIRQQLTGGRDYGEYPGWKQLGQNAKGENFTIVDSLADTRQRVIGLVDLVKGLEARVSKLEGGK
Physico‐chemical
properties
protein length:271 AA
molecular weight:29832,3 Da
isoelectric point:5,99
hydropathy:-0,38
Representative Protein Details
Accession
8MT9Q
Protein name
8MT9Q
Sequence length
276 AA
Molecular weight
30399,74130 Da
Isoelectric point
7,72279
Sequence
MVENPITRHQISPNRHSGGRNVSWIVIHTQEGNGRAKDIIPYLCNPAPGGDRSRAVSYNAVVDDTESVLVVPWDQNPWSASNANSRGDHLLSAGSFARWTAAKWLETDDRDGKDENAQMDRLAKLTAYRCKVRGIPPVYVGGKGMPKTPGICGHVDFGAWGGGHTDPGKNFPWAEFIRRVQEYYYGEELNVAAKDEIIAFIRAYVGPIVSDVKDIRQQLTGGRDAGEYPGWSQLGQDEKGRNFTVVDSLGDVRKKVVGLVEAIKSLDARVARLEAK
Other Proteins in cluster: phalp2_23662
Total (incl. this protein): 13 Avg length: 271,0 Avg pI: 6,43
Protein ID Length (AA) pI
8MT9Q 276 7,72279
1M8fS 271 5,90832
7APRh 271 6,53020
7AQ00 270 7,09370
7AQlb 271 5,98881
7wJqK 265 4,77518
8iwGg 269 6,02643
A0A515MGX1 276 7,72279
A0A3G3MB35 271 6,53020
A0A7G8LIK9 270 7,09370
A0A7G9UZC4 271 5,98881
A0A5Q2WFX5 271 6,23105
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_10922
4ERj9
 80 34,6% 173 1.798E-30
2 phalp2_32349
gl93
 55 30,7% 195 2.447E-30
3 phalp2_28068
7hwGT
 11 31,5% 200 2.114E-29
4 phalp2_7436
4Ksn7
 7 40,4% 183 1.340E-28
5 phalp2_16608
eqCG
 19 33,0% 254 2.447E-24
6 phalp2_18569
7cxQw
 45 30,9% 249 3.219E-22
7 phalp2_22201
6VaYI
 26 33,8% 210 1.087E-21
8 phalp2_23125
4E9CJ
 94 32,9% 170 2.703E-21
9 phalp2_558
HtN7
 28 28,0% 196 7.592E-20
10 phalp2_35315
7b5mp
 11 31,6% 177 7.782E-17

Domains

Domains [InterPro]
Ami2
Unannotated
Representative sequence (used for alignment): 8MT9Q (276 AA)
Member sequence: A0AAE8Y7D2 (271 AA)
1 276 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Gordonia phage Kudefre
[NCBI] 		2885975 Octobienvirus > Octobienvirus kudefre
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OK040786 [NCBI]
CDS location
range 28912 -> 29727
strand +
CDS
GTGGTTGAGTCTTCGATCACCCGGACGCAGATATCGCCGAACAAGCACTACGGGGGCCGGGACGTCGACTGGGTTGTGATCCACACCCAGGAGGGCAATGGGCGGGCGCGGGATATTATCCCGTTCCTGTGCAACCCGGCGTCCGAGGTCTCCTATAACGCGGTTGTTGACGATGTGGAGTCGGTGCTTGTTGTGCCGTGGGACGCCAATCCGTGGGCGGCGATGAACGCCAACACGAGGGGCGACCACCTGTTGTCGGCCGGCTCTTTCGCTAAGTGGTCTAAGGCTAAGTGGCTTGAGATTGATGCGCGGGACGGCAAGAACGAGAACGCGCAGATGGATCGGCTGGCGTTGTTGACGGCGTGGCGGTGCAAGGTTCGGGGTATTCCCCCGGTGTATGTGGGCGGCAAGGGCCGTCCTTCTAAGCCCGGTATTTGCGGGCATGTCGACTTTGGGGCTTGGGGCGGTGGTCATACCGATCCTGGGCCGAACTTTCCCTGGATCGAGTTTATCTCCCGTGTTCAGGGCTTCTACTACGGTGAGGATTTTGATATGGCCGCTAAGGATGAGGTTATCGACTTCATTAAGGGCTTCGTTGGGCCGATCGTGTCCGACGTTAAGGACATTCGTCAGCAGCTCACGGGTGGCCGTGACTATGGCGAGTATCCGGGCTGGAAGCAGCTCGGGCAGAACGCTAAGGGCGAGAACTTCACGATTGTTGATTCGTTGGCGGATACCCGTCAGCGGGTGATCGGTTTGGTGGATCTTGTTAAGGGTTTGGAGGCGCGGGTCTCCAAGTTGGAAGGTGGTAAGTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8MT9Q) rather than this protein.
PDB ID
8MT9Q
Method AlphaFoldv2
Resolution 94.20
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50