Protein

Protein accession
A0AAE7SDC2 [UniProt]
Representative
4LGW5
Source
UniProt (cluster: phalp2_13476)
Protein name
NlpC/P60 domain-containing protein
Lysin probability
100%
PhaLP type
VAL
Probability: 99% (predicted by ML model)
Protein sequence
MGIAEKFNDARKKKKDDKGKDGKEQSKFKDFLDATPLGMVMNMGSEYSKLMSSRVGQDMKKNPKSFAKSLFSLTPVAALYNMAENGFDPNKPSKSVWGKISNFFSSITDKLKDIVKGLGSVNANAASTGGNSGGSGAGKNLSKDFGSVARFYETGKEDFSGAGYISSGVGDAGGKSYGIYQLSSTKGSLANFVKWLGSAHPDLAKKLSGSPGSSSFDASWKKLGQNKAFGEAQQEYFQKDFYNPGLAKINKALGTDLSGRSRGIQELILSASVQHGAGGATSLFKRALARKNISKLSDNQIIDLVQKQRLSQYMGQYAGTNQEAGLRRRAKEEGAKLKDLTNQKVSSSKENKNTSKDIGSNLGSVMSNNGSSDKTDGQSIGYKDVEYAKKYIGTPYSMGPSSGLGKTKTFDCSSLVMNAYNSVGKKLPRTSREQYKATKRIKKDELSIGDLIFFSANPDGSISHVGIYISEGKMINAESSKGVNIRSDALNMPADWFGRLVGFGRVSGNTGGTADGSAELSGTGEVNEETEEQKSRANFKLTEEEKKAIGDRINSKYAKEYGLKGDNEDFSNGKDGSNSTSATAEPSKSGGSKG
Physico‐chemical
properties
protein length:594 AA
molecular weight:63435,0 Da
isoelectric point:9,52
hydropathy:-0,72
Representative Protein Details
Accession
4LGW5
Protein name
4LGW5
Sequence length
199 AA
Molecular weight
21589,10560 Da
Isoelectric point
6,81269
Sequence
MKAKILALAGAILLSMNVGAYAASAATGDDIVNTGEKYLGVPYSYGAVYGNVSSFDCSSFTEYIYAQNGVTLPRVSRDQAKVGTQVSVNNLQKGDLLFFDINRDGVVDHVSIYVSPYYMLGAQSSTGVAFADTHYYWGNYLVQARRVLETQTSVATYTVVSGDTLWGISQKFHTTVSAIQQKNNMTSTTIYVGQKLLLP
Other Proteins in cluster: phalp2_13476
Total (incl. this protein): 2 Avg length: 396,5 Avg pI: 8,17
Protein ID Length (AA) pI
4LGW5 199 6,81269
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_13021
4419T
 1 40,4% 126 7.898E-24
2 phalp2_11110
5hYHo
 20 41,7% 127 3.487E-20
3 phalp2_2843
8JxjE
 191 32,8% 143 1.644E-19
4 phalp2_16267
7ML59
 15 33,3% 147 5.675E-19
5 phalp2_26401
1DLLS
 22 33,8% 127 2.323E-17
6 phalp2_34977
4HgdV
 3 35,1% 131 2.370E-15
7 phalp2_10818
47kHG
 99 30,6% 124 5.119E-14
8 phalp2_28888
5nEcp
 3 29,1% 199 3.138E-11
9 phalp2_29437
1mwuT
 1 26,6% 139 7.337E-09
10 phalp2_10891
4yt2F
 36 28,1% 213 8.143E-08

Domains

Domains [InterPro]
Disordered region
NLPC_P60
LysM
Representative sequence (used for alignment): 4LGW5 (199 AA)
Member sequence: A0AAE7SDC2 (594 AA)
1 199 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00877, PF01476

Taxonomy

  Name Taxonomy ID Lineage
Phage Listeria phage LPJP1
[NCBI] 		2852115 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MZ422438 [NCBI]
CDS location
range 68099 -> 69883
strand -
CDS
ATGGGTATTGCTGAAAAATTCAATGATGCTAGAAAGAAAAAGAAAGATGATAAAGGTAAAGATGGTAAAGAACAAAGTAAGTTTAAAGACTTTTTAGATGCTACTCCATTAGGAATGGTTATGAATATGGGTTCTGAATACAGTAAATTAATGTCATCTAGAGTAGGTCAAGATATGAAAAAGAATCCTAAATCATTTGCTAAATCTTTATTCAGTCTTACTCCGGTTGCAGCATTATATAATATGGCGGAAAATGGATTTGATCCAAATAAACCATCTAAATCAGTATGGGGTAAAATAAGCAATTTCTTCTCATCAATTACTGATAAATTAAAAGATATTGTAAAAGGATTAGGTAGCGTTAATGCAAATGCTGCATCGACTGGTGGAAACTCTGGCGGTTCCGGAGCTGGAAAGAATCTTTCAAAAGACTTTGGTTCAGTAGCCAGATTTTATGAAACTGGTAAAGAAGACTTTAGTGGTGCGGGATATATCTCTAGTGGGGTTGGAGATGCCGGCGGTAAATCTTACGGTATTTACCAATTATCATCTACTAAAGGATCACTGGCTAATTTTGTTAAATGGTTAGGATCAGCTCATCCAGACCTTGCTAAAAAGCTTAGTGGTTCTCCAGGTTCATCTAGCTTTGATGCTTCTTGGAAAAAATTAGGACAAAATAAAGCATTTGGTGAAGCACAACAAGAATACTTCCAAAAAGACTTCTATAATCCAGGACTAGCTAAAATAAATAAAGCACTGGGAACTGATTTAAGTGGTCGATCTAGAGGTATTCAAGAATTAATTTTAAGTGCTTCAGTACAGCATGGTGCTGGAGGTGCAACTAGTCTATTTAAACGTGCATTAGCCAGAAAAAATATTAGTAAACTATCAGACAATCAAATTATTGATTTAGTCCAAAAACAAAGATTAAGTCAATATATGGGTCAATATGCAGGAACCAATCAAGAAGCGGGATTAAGAAGACGTGCTAAAGAAGAGGGTGCAAAACTAAAAGATCTTACAAACCAAAAAGTATCGTCTAGTAAAGAAAATAAAAATACCAGTAAAGATATTGGAAGTAATTTAGGTTCTGTAATGTCCAATAATGGAAGTTCTGATAAAACTGACGGACAATCTATAGGATATAAAGACGTAGAATATGCTAAGAAGTATATCGGTACTCCATACTCAATGGGACCAAGTTCTGGTTTAGGTAAAACTAAGACCTTTGACTGTTCTAGTCTAGTTATGAATGCATACAATTCTGTCGGTAAGAAACTTCCACGTACTTCTAGAGAACAATATAAAGCTACTAAAAGAATTAAAAAAGATGAACTATCTATTGGTGATTTGATATTCTTCTCAGCAAACCCAGATGGTTCTATTTCCCACGTAGGTATTTATATCAGTGAAGGGAAAATGATCAATGCTGAATCTAGTAAAGGTGTAAACATTCGTAGTGATGCATTAAATATGCCTGCAGATTGGTTTGGTAGATTAGTAGGATTTGGTAGAGTTAGTGGAAACACTGGAGGTACTGCTGATGGTAGTGCAGAACTGTCTGGTACTGGAGAAGTTAATGAAGAAACTGAAGAACAAAAATCAAGAGCTAACTTTAAACTAACTGAAGAAGAAAAGAAAGCTATCGGTGATCGTATTAACAGTAAATATGCTAAAGAATACGGTCTAAAAGGAGATAATGAAGACTTCTCTAATGGTAAAGATGGTAGTAATTCAACTTCAGCAACCGCTGAACCTTCTAAAAGTGGTGGCTCTAAGGGTTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008234 cysteine-type peptidase activity molecular function None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4LGW5) rather than this protein.
PDB ID
4LGW5
Method AlphaFoldv2
Resolution 87.14
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50