Protein

Protein accession
A0AA96GZ14 [UniProt]
Representative
8LyZr
Source
UniProt (cluster: phalp2_2847)
Protein name
Lysin A
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSDLSTRSSGTSTVTRMPRYMPLRAGTYTLSSGFGPRWGSQHRGLDFAAKDGTPIYAAQGGTVAYIGRADGFGQWIVIDHPAADGGGTTVYGHMWDAFATGLRQGQRVEAGQLIAYVGTNGQSTGPHLHFEVHPTVWRQGSQIDPKPWLANARNPGDPAPAPAPPKGGTLAKLTDPFTGELWSPNRYHPRGLGDPRWIVVHTQEGGRTARDLAAYLAQKSSQVSYHVVVDDREVLKVVAEGDAPWAAAGANKYAFHICMAGSYASWSRNKWLDVDTSDGKNEDVQLTKTAHVIAWWCDKYGIPPVWIGGRNIPPWGLDGVCGHVDLGAWGGGHTDPGPNFPRDELMRRVSQFLAGTELPPLPTPPPVTVPGTKPDQYGDWMLYRGNPRNDADRVRRVQRRLKAAYRSYAGHLEIDGDFGPLTELAVREFQRRSLLVADGIVGPNTAAALKP
Physico‐chemical
properties
protein length:451 AA
molecular weight:49037,5 Da
isoelectric point:8,81
hydropathy:-0,47
Representative Protein Details
Accession
8LyZr
Protein name
8LyZr
Sequence length
436 AA
Molecular weight
46758,17540 Da
Isoelectric point
6,07662
Sequence
MTRFLPLKEGTFRWGSPFGWRPGGDHYGQDFEAADGTPIYAAQAGTVAYIGAASGFGQWIVIDHPAADGAGTTVYGHMWDAFATGLRQGDWVGAGQLIGYVGSNGQSTGPHLHFEVHPTVWRAGSQIDPRPWLSGALNPGGALTPPPSTGGGNLWTGDPVWLEEVLGAELGDRLRTLPGWKNRGHGDFKDIRGVMWHHTGNGRASAESIRDGRPDLAGPLANLHIAQNGIVTIVAVGVCWHAGSGSYPWLPTNMGNWHMIGVECAWPMDTSGRINASYQAERWPDEQIISMRDVAAALSLKLNVGADHNIGHKDYAGATQGKWDPGYLDMRWFQGEVAKDMQGMFGGPVPPPPPPPVVDPPVSNGYAHILIYRGMTGPAVRALQTRLKRAYSKLVVDGDFGPHTEACVRDYQKLHPPLAADGIVGPATAAMLELVI
Other Proteins in cluster: phalp2_2847
Total (incl. this protein): 374 Avg length: 428,3 Avg pI: 7,53
Protein ID Length (AA) pI
8LyZr 436 6,07662
1Bu7s 359 6,55748
1o8pk 386 6,46000
2CE5U 417 5,79072
2Zn9O 364 5,79675
3NSbF 400 5,94868
3VRW 458 6,56646
47Mae 462 6,38162
48zZx 383 6,70481
4LsTj 413 5,61947
4arVY 462 6,63131
4ffz3 368 5,94595
4pcEq 398 6,67838
4rayX 399 6,02297
55UBw 383 7,82931
57tDG 394 6,90505
5f8Kd 431 7,31605
5in4j 448 9,07936
5kIMQ 382 6,96854
5l2nc 390 8,38265
5ndxm 393 8,31676
6Se8E 427 6,93279
6SmwY 423 5,67562
7Ad8W 427 7,76622
7AdlG 428 7,77561
7PXlL 449 7,30275
7VxDP 389 6,22639
7i1dz 406 6,09924
7pHuQ 406 5,88945
7q5r6 406 5,99176
7qFhp 461 8,21032
7qHAF 437 6,21281
7qhA5 406 5,98875
7qlxd 406 5,98875
7qmTU 406 6,09924
7qr2M 422 5,44889
7zSmv 427 7,26694
80kNZ 363 6,30534
8A7rU 341 6,92926
8JOkD 452 6,97593
8JOmd 406 5,99182
8JOme 427 7,26973
8LrCb 428 8,27195
8Lzm2 448 7,27172
8Lzrd 451 8,50185
8Lztk 449 7,32969
8MIFx 428 7,33964
8MKFk 428 7,28121
8ML4R 429 7,81694
8doOQ 360 5,99216
8qBmf 367 5,87814
l5Vb 399 5,76537
uKGd 286 5,83852
A0A482JAE8 436 6,07662
A0A386KGY7 453 6,42664
A0A345MF39 414 6,04019
A0A2D1GA73 432 5,74531
A0A7M1CMJ7 422 5,96851
Q855S8 454 5,80999
W8ED04 449 7,30275
A0A0K2FNU8 428 5,74525
A0A481VSN0 438 6,34132
S5Y3I1 406 5,95709
A0A2Z4Q5C9 156 6,27027
G8I449 416 5,65562
A0A0K0N6L3 357 7,25495
Q716M6 429 7,80050
A0A023ZWN3 452 6,97593
G1JY01 438 6,34075
A0A088FUQ2 455 8,30999
A0A345M9H2 456 8,30999
A0A2Z5H8V1 435 8,61074
R4TD98 442 8,31006
A0A1D8ERN4 442 8,31006
A0A1I9SBQ7 429 8,31786
A0A2P1JWL6 434 7,79676
A0A2P1CC23 155 8,57502
A0A2P1JR63 424 5,97062
A0A1D8EVX2 448 7,27172
A0A5J6TGH0 451 8,50185
A0A5J6T877 441 8,75656
A0A5J6TI81 449 7,32969
A0A6M2YSS8 283 5,39927
A0A649VFV6 423 6,22941
A0A2S1PCZ0 432 5,75042
A0A023ZXF1 429 8,31786
A0A059VKL5 442 7,79295
A0A068F265 451 8,81336
A0A076GE73 406 5,80016
A0A088FB91 438 8,81349
A0A088FRM7 451 8,61119
A0A0A0Q4E0 438 6,34075
A0A0B5A0K7 438 8,81349
A0A0H4IQH6 429 8,31786
A0A0K1LSK8 429 8,31786
A0A0K2FMY5 428 5,64698
A0A0K2FNX7 406 5,80016
A0A0N9S7A8 436 7,25364
A0A1C9LXR8 438 8,81349
A0A1D8ER67 438 8,62015
A0A1I9SBF8 443 8,31006
A0A1J0MIT7 442 8,31006
A0A1U9WRQ3 428 5,64698
A0A222YWW5 438 8,62015
A0A2D1GAC1 438 8,81349
A0A2D1GEV9 452 6,99872
A0A2D1GGT5 438 8,81349
A0A2D1GJ52 438 8,81349
A0A2D1GKP9 429 7,80050
A0A2H4PEH7 406 6,21275
A0A2K9VDX0 429 7,80050
A0A2L1IXH7 438 8,62015
A0A2L1IXW1 438 8,62015
A0A2P1A1Z8 406 5,80016
A0A2P1CDX9 442 8,31006
A0A2P1CFN0 443 8,31006
A0A2P1CG11 438 8,62015
A0A2P1CHX5 429 8,31786
A0A2P1CKB2 438 8,81349
A0A2P1JW98 451 8,81336
A0A2P1JX33 438 8,62015
A0A2P1K029 438 8,81349
A0A2P1N4E4 406 5,95709
A0A2S1PCM6 438 8,62015
A0A2U8UGI3 433 7,79682
A0A2Z5H449 438 8,62015
A0A2Z5H605 429 8,31786
A0A2Z5HF92 429 7,25444
A0A345KLH4 438 8,62015
A0A345KMT0 431 7,80050
A0A345KTI6 438 8,62015
A0A345KXJ3 438 8,81349
A0A345M528 438 8,81349
A0A345MAP4 435 8,31773
A0A345MDN1 438 8,81349
A0A345MFF3 438 8,81349
A0A385D1U0 452 6,99872
A0A385DWZ8 442 8,31006
A0A385DZG8 438 8,62015
A0A385E1A3 438 8,81349
A0A385UEY8 452 6,99844
A0A386K7Y2 438 8,62015
A0A386KDM0 429 8,31786
A0A386KF82 438 6,23395
A0A386KK39 438 8,62015
A0A386KNA8 438 8,62015
A0A386KQB0 438 8,62015
A0A3G3LX55 442 8,31006
A0A3G3LYI7 406 5,80016
A0A3G8FLQ8 438 8,81349
A0A3G8FLV8 438 8,62015
A0A3G8FMH8 438 8,62015
A0A3G8FQ98 438 8,81349
A0A3G8FQT3 438 8,81349
A0A3G8FRG1 438 8,81349
A0A3G8FV04 438 8,62015
A0A3S9U9D0 438 8,81349
A0A3S9UA29 438 8,62015
A0A3S9UBW8 438 8,62015
A0A3S9UCQ1 438 8,81349
A0A3S9UDJ3 438 8,81349
A0A3S9UDS2 438 8,81349
A0A3S9UF36 438 8,62015
A0A3S9UFI5 438 8,81349
A0A3S9UG72 438 8,62015
A0A3S9UGG5 438 8,62015
A0A3S9UGX3 438 8,81349
A0A3S9UHP8 438 8,62015
A0A3S9UHZ6 438 8,81349
A0A3S9UIL7 443 8,31006
A0A3S9UIR6 438 8,81349
A0A3S9UJF2 438 8,62015
A0A3S9UKH0 438 8,62015
A0A3S9UKJ1 438 8,81349
A0A3S9UL21 438 8,81349
A0A3S9ULQ3 438 8,62015
A0A3S9UM30 438 8,62015
A0A3S9UMM9 438 8,62015
A0A3S9UPA1 438 8,62015
A0A3S9UQC5 438 8,81349
A0A3S9W0S7 438 8,81349
A0A411BMM1 438 8,81349
A0A481W1M4 442 7,79295
A0A482JD33 429 8,31786
A0A482MER4 452 6,99872
A0A4D6E3J8 156 7,82803
A0A5P8DEC7 406 5,80016
A0A5P8DEJ0 414 5,54433
A0A5Q2WCU2 438 8,81349
A0A5Q2WJL5 438 8,81349
A0A5Q2WLN3 438 8,81349
A0A649V4S7 406 5,95709
A0A649VWH9 442 8,31006
A0A6B9JF29 438 8,62015
A0A6G6XRE7 438 8,62015
A0A6G6XTF3 438 8,81349
A0A6G9LC98 452 6,99872
A0A6M3SYM6 438 8,62015
A0A6M3SZD1 438 8,81349
A0A6M3T793 438 8,62015
A0A6M3T7V5 438 8,62015
A0A7G8ZZL1 452 6,99872
A0A7G9W0J8 438 8,62015
A0A7G9W0U7 438 8,61074
A0A7G9W2V5 438 8,81349
A0A7L7SQZ8 438 6,34132
A0A7L7STC4 406 5,80016
A0A7L7SXN6 406 5,80016
A0A7M1CJK2 451 8,32559
A0A7T1KTW6 433 4,83844
A0A7T1NVT6 406 5,95709
B5U5V5 438 8,62015
C9DAC6 433 7,25364
C9DCB7 438 8,81349
C9DD07 438 8,62015
D2XRZ5 438 8,62015
G1BK67 438 8,62015
G1BN19 435 7,25364
G1BNW0 438 8,62015
G1BQV3 438 8,81349
G1D201 442 8,31006
G1D2P3 438 8,81349
G1D6P0 438 8,62015
G1D9Q2 438 8,81349
G1DIR9 438 8,81349
G1DJ21 438 8,62015
G3MBX9 438 8,81349
G3MC77 429 7,80050
G8I8L5 431 7,80050
G8I969 438 8,81349
I3WWS1 454 5,91531
L7TG43 442 8,31006
L7THA7 442 8,31006
L7THP4 435 7,25364
L7TI47 438 8,81349
L7TMN8 442 8,31006
Q856M5 406 5,80016
R4JHJ5 429 8,31786
R4JKX7 438 6,34075
R4JLW0 438 6,34075
S5YLN8 406 5,80016
V5UPD4 451 8,81336
W8FU30 451 8,81336
X2KRR9 438 8,62015
X2KSL8 438 8,62015
X4YVN8 438 8,62015
A0A9E7SEH0 428 5,55507
A0AAE7S258 454 5,80743
R4JEG2 438 6,34075
R4JFH6 438 6,34075
R4JKS2 438 6,34075
R4JM69 438 6,34075
A0A088FTD9 429 8,31786
A0A0A7RV81 429 7,80050
A0A0A7RWZ0 429 7,80050
A0A0C5AMR8 438 6,34075
A0A0H4ITG0 455 8,30999
A0A0K1Y6B3 438 6,34075
A0A0M4RR43 438 6,34075
A0A0M5M7B1 438 6,34075
A0A142K5X7 435 7,25364
A0A162CHP9 429 8,31786
A0A162CJG2 429 8,31786
A0A1B1IY64 438 6,34075
A0A1C9LZT6 455 8,30999
A0A1C9M100 429 7,80050
A0A1C9M298 429 8,31786
A0A1D8EWV0 438 6,34075
A0A1D8F081 438 6,34075
A0A1S6KWC2 429 8,31786
A0A1S6KWI1 429 8,31786
A0A1S6KWT2 429 8,31786
A0A220NSI9 429 7,80050
A0A249XP22 429 8,31786
A0A2D1G842 443 6,13807
A0A2D1GC79 442 8,61067
A0A2D1GFM6 429 7,80050
A0A2L1IZB2 434 7,79676
A0A2P1JQ49 429 8,31786
A0A2R4A1H5 438 6,34075
A0A2R4ANV2 429 8,31786
A0A2S1PCT1 438 6,34075
A0A2U8UG77 429 8,31786
A0A2U8UPI8 434 7,79676
A0A2Z4Q1Q0 434 7,79676
A0A2Z5H5Q4 438 6,34075
A0A2Z5H6J1 429 7,80050
A0A2Z5H7J5 438 6,34075
A0A2Z5HD49 429 7,80050
A0A345KNZ1 438 6,34075
A0A345KRQ9 429 7,80050
A0A345KS84 429 8,31786
A0A345KSS6 429 8,31786
A0A345KTA3 438 6,34075
A0A345KZK8 429 8,31786
A0A345M5X4 440 8,31006
A0A345MJB2 438 6,34075
A0A385DZ81 435 8,31773
A0A385UKG1 429 7,80050
A0A386KG26 438 6,34075
A0A386KH92 438 6,34075
A0A386KHM4 438 6,34075
A0A3G8FLE1 429 7,80050
A0A3G8FPQ6 435 8,31773
A0A3G8FS50 435 8,61074
A0A3S9UBG3 429 8,31786
A0A3S9UE70 435 8,61074
A0A3S9UET5 434 7,79676
A0A3S9UJ11 429 8,31786
A0A3S9UK91 435 8,61074
A0A3S9UKS6 434 7,79676
A0A3S9UQX8 435 7,25364
A0A411BPV6 438 6,34075
A0A411CV69 438 6,34075
A0A481VSV8 438 6,34075
A0A514A4G2 438 6,34075
A0A514U085 429 8,31786
A0A7G8LRB3 434 7,79676
A0A7G9UXN1 402 6,42488
A0A7G9W097 429 7,80050
A0A7L7SQR7 402 6,42488
A0A7L8ZFD6 429 7,80050
A0A7S8BDS3 438 6,34075
A0A7T0Q5S1 438 6,34075
A0A899IP77 429 7,80050
A0A899ITY1 413 6,34774
A0A899J0G7 433 4,98594
A0A8F3E501 406 5,95709
A0A8F3IL91 438 8,81349
A0A8F3IM45 438 8,32566
A0A8T8JGH5 402 6,42488
A0A977TFB9 438 6,34075
A0A9E7E515 438 6,34075
A0A9E7E5Q5 438 6,34075
A0A9E7LCQ8 436 6,07458
A0A9E7LMM9 438 6,34075
A0A9E7NDW3 429 8,31786
A0A9E7NH65 435 8,31773
A0A9E7P5G3 448 6,75880
A0A9E7QC03 438 8,81349
A0A9E7QJM2 438 6,34075
A0A9E7QPZ4 438 6,34075
A0A9E7S0B4 438 6,34075
A0A9E8M7Q3 435 8,61074
A0A9E8M878 402 6,33939
A0A9E8RZN4 402 6,42488
A0AA96GNT6 429 7,80050
A0AA96GU98 438 8,81349
A0AA96GXI7 435 7,25364
A0AA96H4P9 435 8,31773
A0AA96JYX0 429 8,31786
A0AA96QX44 438 8,81349
A0AAE7XCF2 429 7,80050
A0AAF0GJI2 438 8,81349
A0AAU8GNE6 454 5,22381
A0AAU8GNI1 402 6,45778
A0AAV2YAT5 486 5,08132
A0AB38ZP33 406 5,80016
A8WA19 402 6,42488
B2D190 438 6,34075
C5IYA7 438 6,34075
C9DB73 438 6,34075
D2XS97 429 7,80050
G1FFW6 431 8,31786
G8I2Y1 429 7,80050
G8I383 429 7,80050
G8I6Y8 438 6,34075
G8I8W7 429 7,80050
G8IBL2 429 7,80050
Q19ZL8 429 7,80050
Q1A0Q2 438 6,34075
R4JE24 438 6,34075
R4JFM4 438 6,34075
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_36825
6W23o
 94 30,5% 357 6.970E-94
2 phalp2_28062
7ebmV
 12 31,4% 385 1.985E-56

Domains

Domains [InterPro]
PET_M23
Ami2
PG_1
Representative sequence (used for alignment): 8LyZr (436 AA)
Member sequence: A0AA96GZ14 (451 AA)
1 436 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01471, PF01510, PF01551

Taxonomy

  Name Taxonomy ID Lineage
Phage Mycobacterium phage MiniBoss
[NCBI] 		3077147 Pegunavirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OR434024 [NCBI]
CDS location
range 40330 -> 41685
strand +
CDS
TTGTCGGATTTGTCAACACGTTCATCGGGCACGTCTACCGTGACACGTATGCCGAGGTACATGCCCCTGCGCGCGGGCACCTACACACTGTCGTCCGGTTTCGGCCCGAGGTGGGGCAGCCAGCACCGTGGCCTCGATTTCGCCGCCAAGGACGGCACACCGATCTACGCTGCGCAGGGCGGCACCGTGGCCTACATCGGCAGAGCCGACGGTTTCGGGCAATGGATCGTGATCGACCACCCCGCCGCCGACGGTGGCGGCACGACCGTCTACGGACACATGTGGGACGCGTTCGCCACCGGACTACGTCAAGGGCAGCGCGTCGAGGCCGGGCAGCTCATTGCCTACGTCGGCACGAACGGTCAATCGACCGGCCCACATCTGCACTTCGAGGTGCACCCCACCGTGTGGCGGCAGGGGTCGCAGATCGATCCCAAGCCGTGGCTGGCCAACGCGCGCAACCCCGGCGACCCCGCCCCGGCACCCGCACCACCCAAAGGAGGAACATTGGCCAAGCTGACAGATCCGTTCACCGGCGAGCTGTGGTCGCCGAACCGCTACCACCCGCGCGGTCTCGGCGACCCCAGGTGGATCGTGGTGCACACCCAAGAGGGCGGGCGTACGGCGCGCGACCTCGCGGCCTACCTCGCGCAGAAGTCGAGCCAGGTCTCGTATCACGTCGTGGTCGATGACCGCGAGGTGCTCAAGGTCGTCGCCGAGGGCGATGCACCGTGGGCGGCGGCGGGCGCGAACAAGTACGCGTTCCACATCTGCATGGCTGGTAGCTACGCGTCGTGGTCGCGCAACAAATGGCTCGATGTCGACACGTCCGACGGCAAGAACGAGGACGTGCAGCTCACCAAGACCGCGCACGTCATCGCATGGTGGTGCGACAAGTACGGCATCCCACCGGTGTGGATCGGTGGCCGCAACATCCCGCCGTGGGGCCTCGATGGTGTGTGCGGACACGTCGATCTCGGCGCGTGGGGCGGTGGCCACACCGACCCCGGCCCCAATTTCCCGCGCGACGAGCTCATGCGGCGCGTGAGCCAATTCCTCGCGGGCACCGAGCTGCCGCCGCTGCCGACACCGCCGCCGGTCACCGTGCCGGGCACCAAGCCCGATCAGTACGGCGATTGGATGCTCTACCGAGGCAACCCGCGCAACGATGCCGACCGTGTCCGGCGCGTGCAGCGGCGGCTCAAGGCGGCGTATCGGTCCTACGCGGGTCACCTCGAAATCGACGGCGATTTCGGCCCGCTCACCGAGCTCGCCGTGCGCGAGTTCCAGCGTCGCAGCCTGCTCGTCGCCGACGGCATCGTTGGCCCCAACACCGCAGCCGCCCTCAAACCGTAG

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0004222 metalloendopeptidase activity molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8LyZr) rather than this protein.
PDB ID
8LyZr
Method AlphaFoldv2
Resolution 83.34
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50