Protein

Protein accession
A0A9E7MFC2 [UniProt]
Representative
tx2m
Source
UniProt (cluster: phalp2_11491)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MVVLVLDAGHGGHDSGAVGYGLKEKSLALDIVKGIKLGLEKYGNIEVVLTRKNDTYLTLEQRVQIEKKAKANMYVSVHLNAGGGTGFESYVDERLDNDSRTVKRQRILHDAIMKELHKINKNLANRGTKKANYYVIRNTNSDAVLTENLFIDTKKDTDLLKQHKTIQAIINGHVKGIVKIFNLRKKVIDTPIDEEEKEVVERKYVYRVVAGSYKEKKNATTQVTLLKKKGIDSFVIREGGLYKVVAGSYNEQRNAKRQIDRLKNKDIETFIQKY
Physico‐chemical
properties
protein length:274 AA
molecular weight:31105,5 Da
isoelectric point:9,64
hydropathy:-0,55
Representative Protein Details
Accession
tx2m
Protein name
tx2m
Sequence length
354 AA
Molecular weight
39378,78250 Da
Isoelectric point
10,09809
Sequence
MIKIYIDPGHGGRDSGALGNGLKEKDLTLDIAKRIEKYLKEKYTGFSLKFSRKTDKYLSLAQRYNDANKWNADLFVSIHINAGGGTGFESFAFNGKVQSNTLTNQSTIHDSVVSAISSYKLRDRGKKRANFAVLRETKMAAFLSENLFIDTKSDADLLKTTKFKNAVAKGHAEGIAKAMKLKTKSKETTSTTKPSKPAKPSKPATSSSKKKSSKYTGNSIVDYLKSIGVDSSQKNRKKLAKKYGVKNYDFSAKKNLELLAVMRDGKTKTKSFPSSNKKSSYIGKRVESIHVGKLRFYNKPSWKDKDVAGHMGKGYGFPTILDKVKVENGYQYKVKNSRGKVFYVTASSKYVRVV
Other Proteins in cluster: phalp2_11491
Total (incl. this protein): 34 Avg length: 281,1 Avg pI: 9,69
Protein ID Length (AA) pI
tx2m 354 10,09809
7lzj0 266 9,76627
7r4ot 312 9,80778
7ua2R 332 10,08706
7uzRI 266 9,78142
7wMy4 312 6,20582
aXPq 272 9,78097
tw9q 334 10,23237
A0A0K1LMD7 275 9,37224
A0A0N6W8I1 291 9,80231
A0A142F1B8 311 10,42604
A0A1S5QTQ1 299 9,85813
A0A290GJY1 208 9,61747
A0A3B6XHD1 283 9,70393
A0A514AAU4 239 9,63959
A0A6B9SZH0 239 9,72443
A0A6M9Z701 299 9,85813
A0A7D7KKI1 299 9,86729
A0A7T8EP45 237 9,65467
A0T2N4 233 9,28263
A6M970 233 9,28263
M1I9K4 299 9,88837
M1IE59 299 9,82235
M1IEI0 299 9,88837
U5PTK7 299 9,86729
U5PWK4 299 9,81449
A0A4D6BSI4 281 9,88128
A0A977SP25 239 9,69812
A0A9X9P7T8 232 9,73332
M1HNA7 303 9,88869
M1IDI0 299 9,92479
Q9FZW0 239 9,69793
U5PW24 303 9,80617
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_9307
7sfyx
 22 30,8% 360 5.167E-43
2 phalp2_6489
uh4U
 19 34,0% 300 1.769E-42
3 phalp2_15036
7cnpE
 7 29,3% 371 7.044E-39
4 phalp2_32087
63Erl
 43 32,3% 235 3.106E-34
5 phalp2_23918
1NTlO
 42 33,7% 228 1.196E-32
6 phalp2_27210
3o9DV
 88 28,5% 235 1.837E-31
7 phalp2_16523
72lcf
 2 26,5% 365 4.322E-26
8 phalp2_26584
8m9Pf
 2 27,6% 228 6.051E-22
9 phalp2_40361
3ATRP
 5 25,7% 322 2.990E-19
10 phalp2_29175
7A7gP
 25 28,0% 235 4.594E-12

Domains

Domains [InterPro]
Ami3
DUF3597
Unannotated
Representative sequence (used for alignment): tx2m (354 AA)
Member sequence: A0A9E7MFC2 (274 AA)
1 354 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01520, PF12200

Taxonomy

  Name Taxonomy ID Lineage
Phage Kurthia phage vb_KgiM_P1
[NCBI] 		2951632 Rountreeviridae >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
ON637248 [NCBI]
CDS location
range 14077 -> 14901
strand +
CDS
ATGGTAGTATTAGTGTTAGATGCTGGACATGGTGGACATGATAGTGGTGCTGTTGGTTATGGGTTAAAAGAAAAAAGCCTTGCACTTGATATTGTAAAAGGTATCAAGTTAGGTCTAGAAAAGTATGGGAATATTGAAGTTGTTTTAACAAGAAAAAATGATACCTATTTAACATTAGAACAACGTGTTCAAATTGAAAAGAAAGCAAAAGCCAATATGTATGTTTCGGTACACTTAAACGCAGGTGGTGGAACTGGTTTTGAATCATATGTTGATGAAAGGTTAGATAATGATTCAAGAACTGTTAAGCGTCAAAGAATTTTACATGATGCCATTATGAAAGAACTTCATAAAATTAATAAAAATTTAGCAAATCGAGGTACTAAAAAAGCAAATTACTATGTTATCAGAAACACCAACAGCGATGCAGTTTTGACTGAAAATCTATTTATCGACACGAAAAAAGATACGGACTTGTTAAAACAACATAAAACAATTCAAGCCATTATTAATGGTCATGTTAAAGGTATTGTAAAAATTTTCAACTTAAGAAAAAAAGTGATTGATACCCCAATTGATGAAGAAGAAAAAGAAGTTGTGGAAAGAAAATACGTTTATCGTGTTGTTGCTGGTTCATATAAAGAAAAGAAAAACGCTACAACCCAAGTAACGCTATTAAAGAAAAAGGGTATTGATTCCTTTGTGATTCGTGAAGGTGGATTGTATAAAGTTGTAGCTGGTTCTTATAATGAACAACGTAATGCTAAAAGACAAATTGACCGTTTAAAAAATAAAGATATTGAAACATTTATTCAAAAGTATTAA

Gene Ontology

Description Category Evidence (source)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042834 peptidoglycan binding molecular function None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (tx2m) rather than this protein.
PDB ID
tx2m
Method AlphaFoldv2
Resolution 86.88
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50