Protein

Protein accession
A0A976SQR0 [UniProt]
Representative
7e47k
Source
UniProt (cluster: phalp2_22245)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MLKGIGAADIPTWNNFEGEAKVYKNTVDFLAKRGDLVIFNRNYGGGYGHVGIVIKATLDYIVVIEQNWLGGAYWTPPEVTTRRTHGYDFPMFFIRPYFAKETKTNAVKSKMTPKKKPKMNKGKKILLVAGHGKGAYSNDPGAVANGYNERDFNRKEVIPRVKKYLESVGNTVVLYGGKKMNQDLYQDTLYGQRVGNYKDYGLYWVKNNVKPDAIVEFHLDAASPKASGGHVIVSDKFPADDIDKALSSTLDKTVGKIRGVTPRNDLLNANVTGSLNLNYRLIELGFITSKKDMNYITKNIDDFTKRIAEAINGRQIEAPKSKPSKAKNTWNWSGTFYPNAPKEGIRVRRSPGLNGAIVESGSWLYRKTDWVKFDRVIKKDGYWFIRFKYQAPGSSNKHFYCAVCKITDEQQKIKNEKYWGTIEWK
Physico‐chemical
properties
protein length:425 AA
molecular weight:48195,5 Da
isoelectric point:9,71
hydropathy:-0,60
Representative Protein Details
Accession
7e47k
Protein name
7e47k
Sequence length
475 AA
Molecular weight
52988,98100 Da
Isoelectric point
9,47010
Sequence
MRTYDEAVKWLDSSVGKQFDFDKAYGYQCYDYTNAYFNYVTGKVLYGMFAKNIHTDNKATLAPIATVYENTEHFLPQKGDIVIFNGRYGGGCGHTAVVNQATLQSFEVIEQNWLEGGWVNNRPGWETATRRWHYYDNPMYFIRLHYASKKSIKNMVASVLPSKSNETKKMKIALVAGHGYNDPGAVGNGTNERDFIRKNIVPNIAKHLRTANHDVYLYGGSTMNQDMYQDTAYGQSVGNYKDYGLYWLKNNQKPDAIVEFHLDAAGPQASGGHVIISSQFKADSIDNKIQSVIKSNVGQIRGVTPRNDLLNVNVSAQINVNYRLAELGFITSGKDMDYIKKNYDKYAKDIAGAIHGKPIGGTAGGAKKAKPKQDKKPPVPTGYKLDKNGVPYKKEKGVYTPTTIKGNNVRKGYSLSSEITGVLANGQSITYDGAYVFNGYRWITYVSNNGRRYIATGKADAKGNRVDYYGRFSKA
Other Proteins in cluster: phalp2_22245
Total (incl. this protein): 317 Avg length: 468,5 Avg pI: 9,37
Protein ID Length (AA) pI
7e47k 475 9,47010
1aZAT 487 9,62179
1bAPh 462 9,74654
1bKH0 431 9,75679
1bMJK 463 9,59807
1bSzA 467 9,70844
1bvIE 467 9,76072
1ca99 469 9,68652
1cjou 460 9,63198
1dON6 458 9,82410
1dPaJ 467 9,74480
1dQAZ 467 9,73977
1e7HQ 471 9,76034
1e8uc 490 9,65674
1ejZz 483 9,54011
1enUS 486 9,55255
1jJyp 483 9,58492
1k5PI 467 9,63694
1lUHP 471 9,76240
1mKg1 455 9,67898
1mKgC 430 9,70973
2VFRf 467 9,36992
5Mu8F 484 9,36618
5OUwz 467 9,70876
5P0D8 425 9,71360
5PhFY 483 9,58047
5VJ4k 467 9,74654
5W0WG 471 9,70064
5Zilp 460 9,48390
5tCN 431 9,73880
63Etz 467 9,79089
63MWH 471 9,77678
6dHyu 464 9,65371
6g5if 467 9,72391
6hxFz 471 9,75428
6kCLX 467 9,78264
6suvh 487 9,60297
6tkQ3 471 9,77678
6uIVR 431 9,84608
6udEY 467 9,72475
71Kut 467 9,69297
720LZ 484 9,29313
721B9 468 9,51194
72DLx 484 9,27934
72Q2A 486 9,48512
73GM7 484 9,24246
74dnH 487 9,63198
74j5O 467 9,75279
74jvz 500 9,41259
751yn 470 8,86616
75DDF 484 9,18915
75bdQ 467 9,44696
75rJO 456 9,65590
75url 484 9,18915
76m5N 484 9,27934
77Bdf 484 9,15839
77E6j 484 9,29307
77Rp5 484 9,27934
77jQ5 484 9,24253
77q6c 484 9,27940
77tMm 484 9,28617
77z37 484 9,27276
78Alk 484 9,27263
78CAw 484 9,24930
78E6u 484 9,15839
78F5a 484 9,24923
78h6T 484 9,30010
78lHi 484 9,29313
78mul 484 9,28617
78p2f 484 9,34858
78qd6 484 9,23576
78qpk 484 9,24246
78rif 484 9,19566
78sQm 484 9,33433
78ubd 484 9,33426
78wgf 470 8,66753
79Mm3 500 9,44373
79NcG 480 9,74138
79WUv 484 9,28617
79rcv 484 9,78206
79uYG 468 9,15175
7AMF7 484 9,32730
7AzTQ 484 9,28617
7AzUX 474 9,11062
7BNt1 467 9,75279
7ByKF 467 9,61251
7C42k 469 9,50504
7QCC6 428 9,67898
7QiBk 470 8,80530
7Qjf9 470 8,67301
7Qk7U 483 9,54714
7RhvL 484 9,24246
7RhwP 484 9,32027
7RiAY 484 9,34136
7RiE8 484 9,24246
7RiQZ 484 9,28617
7RiuX 408 9,34103
7RpvG 393 9,10514
7XwTD 407 9,83776
7a3pG 484 9,20230
7a6yH 470 8,77861
7aA7v 481 9,20907
7aDip 484 9,24246
7aIDu 484 9,28617
7aIN9 484 9,24253
7aIms 484 9,24253
7aJif 484 9,34522
7aKmv 484 9,29307
7aMDP 484 9,28624
7aMKv 484 9,15820
7aMMj 484 9,24253
7aMMy 484 9,13880
7aNYi 484 9,32027
7aOG3 484 9,32027
7aOaX 484 9,15169
7aP7x 484 9,24246
7aQkT 484 9,27263
7ammr 484 9,24923
7ansX 484 9,15839
7aowD 484 9,35212
7apk5 484 9,20230
7arWP 484 9,20907
7asI8 484 9,37314
7asUa 476 9,32034
7av1c 494 9,32040
7axSU 484 9,25619
7ayOv 484 9,24246
7ayS1 470 8,94075
7bAYo 484 9,24923
7bCJc 484 9,23589
7bFKW 484 9,35206
7bFZh 484 9,19566
7bGBJ 484 9,22925
7bHOQ 484 9,32730
7bHTF 484 9,27263
7bIhh 484 9,31357
7bJJi 484 9,15169
7bJX6 462 9,25619
7bKPB 478 9,28617
7bMUv 484 9,35908
7bMbO 484 9,32724
7bi2h 467 9,56216
7biPC 484 9,15169
7bqKH 482 9,68194
7btRt 484 9,27934
7buAY 484 9,22931
7bw0F 484 9,20230
7bwxY 462 9,33446
7bxmf 500 9,38700
7bzeF 484 9,28617
7c6xn 486 9,10411
7cHPH 464 9,73113
7cIQP 484 9,27263
7cPDh 484 9,15175
7cVJS 484 9,24253
7cYcu 460 9,63005
7cYm8 486 9,23589
7cnin 484 9,28617
7cnlA 484 9,24246
7cnmF 484 9,29307
7dSh8 484 9,15839
7dUXu 461 9,81417
7dUlD 484 9,34129
7dYJP 475 9,49234
7dc01 422 9,56951
7dfEj 410 9,20217
7drrP 484 9,23589
7eJva 484 9,30674
7eV4w 484 9,15839
7ewnX 484 9,28617
7f53X 487 9,23634
7f6vK 484 9,27934
7fDb2 484 9,29307
7foBe 484 9,24923
7g7j1 467 9,71598
7gDDS 483 9,53992
7gEaV 447 9,70573
7gJL7 467 9,73178
7gKxz 484 9,13880
7gOn2 500 9,28752
7gj5U 500 9,31808
7gj7i 467 9,72378
7gs5K 470 8,67301
7gsOu 500 9,26954
7gtKl 464 9,65371
7gvKH 482 9,69271
7gz7i 464 9,65815
7h0Nx 467 9,65203
7h0TK 482 9,72701
7hLGA 467 9,72378
7hNGE 500 9,33478
7hVVg 471 9,80353
7hVus 377 9,80037
7hjsj 484 9,32027
7hjsp 484 9,19572
7huyy 484 9,29313
7i0Et 500 9,40009
7i2JS 471 9,65944
7i2RK 467 9,72462
7i2SW 464 9,65190
7i4B8 482 9,83634
7i4Rw 464 9,65371
7i6BH 482 9,72958
7iApL 471 9,61573
7icSQ 482 9,62134
7ihtn 500 9,34103
7ij23 464 9,64636
7ilhT 471 9,81198
7ini7 464 9,66125
7iqXS 464 9,67008
7jls3 484 9,24246
7kG5g 485 9,29242
7kG5m 462 9,56564
7kG6w 462 9,48622
7kN9A 419 9,40782
7kj94 460 9,52077
7l4aD 484 9,10315
7lQwo 500 9,40009
7lwU7 462 9,61554
7mGho 484 9,20230
7mGjZ 484 9,31363
7mvV6 460 9,63959
7qAS5 462 9,18805
7qCfc 462 9,31363
7qCh4 462 9,24820
7qT2s 467 9,56229
7qTkv 467 9,58479
7qVwB 507 9,54063
7qZOs 399 9,73107
7qqi7 462 9,64874
7qsyo 460 9,51323
7qszZ 459 9,60168
7qtHa 462 9,48009
7qtdi 462 9,38745
7qtjW 462 9,27186
7qtr2 462 9,46262
7qtul 462 9,31293
7qurt 462 9,45527
7r96y 463 9,51026
7rBBA 456 9,66157
7rBJy 428 9,72120
7rBLc 455 9,64416
7rBW3 417 7,14190
7rDS8 470 8,66753
7rDet 469 9,55481
7rDqv 484 9,28617
7rE8K 484 9,10308
7rEjk 484 9,32027
7rFgz 470 8,07146
7rxXP 458 9,64159
7ry4C 459 9,68671
7tlw3 484 9,32027
7u8kC 484 9,27940
7uOB1 394 9,28269
7vx28 467 9,73191
7wAbc 450 7,16844
7wAbx 436 6,64734
7wlv5 395 9,07220
7wlyS 490 8,61331
7xxCx 484 9,28617
7xxIk 484 9,20236
7xxXx 484 9,32027
7yceX 484 9,29307
7ychB 462 9,19153
7ychE 462 9,04525
7ycuG 486 9,36876
7zohO 458 9,73126
85aDG 398 9,23073
8KcWC 473 8,67907
8KcWJ 467 9,70876
8KcWU 440 9,70580
8KcWw 456 9,67975
8KcXl 484 9,24923
8KcYI 484 9,28617
8KcYc 484 9,20230
8KcYg 484 9,28617
8KcZH 484 9,27263
8Kd0d 484 9,28617
8Kd0f 484 9,18915
8Kd0r 484 9,15839
8LPFS 460 9,54301
8LVah 484 9,27934
8MfV5 473 8,67881
8dcaP 483 9,59188
8ftAs 467 9,73191
8ftIg 460 9,67459
8fuBJ 462 9,65119
8fuOR 460 9,59124
8fwcd 467 9,74654
8lks5 484 9,16504
Db6f 467 9,75453
oedh 463 9,60381
wyOm 487 9,63939
A0A0F6N3N1 470 8,86616
Q4ZBG9 470 8,80530
Q9FZY0 470 8,67301
A0A1W6JNV3 440 9,70580
A1KX50 470 8,67881
A0A0E3XCX3 473 8,67881
A0A2H4PQS4 470 8,77294
A0A6B7H7U1 470 8,77880
A0A7U0GDL6 467 9,76885
A1KXB8 470 8,77868
M9NRK2 423 8,78970
W5RAP8 423 8,78970
A0AAE7FJ98 467 9,76872
A0A2H4J5F2 323 9,49963
A0A2H4JHF9 426 8,49418
A0A2S0X9X1 121 9,27785
A0A976XGX1 470 8,77861
A0A9E7L9A8 471 9,71540
A0A9E7MMI2 431 9,76369
A0AA49X2S8 431 9,85021
A0AA50ACC2 469 9,50504
A0AAF0K503 431 9,67846
A0AAX4BI33 129 9,22151
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_29175
7A7gP
 25 53,0% 356 2.242E-146
2 phalp2_20990
7yFAa
 82 57,8% 301 3.313E-138
3 phalp2_38184
7bpzP
 284 25,5% 517 9.406E-45
4 phalp2_35363
7xThI
 2 28,1% 355 1.379E-37
5 phalp2_16525
72rfr
 1 25,7% 330 9.319E-30
6 phalp2_5157
238De
 36 29,0% 306 2.927E-17

Domains

Domains [InterPro]
CHAP
Ami3
SH3_5
Representative sequence (used for alignment): 7e47k (475 AA)
Member sequence: A0A976SQR0 (425 AA)
1 475 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01520, PF05257, PF08460

Taxonomy

  Name Taxonomy ID Lineage
Phage Staphylococcus phage Lacachita
[NCBI] 		2973490 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
OP142323 [NCBI]
CDS location
range 26328 -> 27605
strand +
CDS
ATGTTAAAAGGCATAGGCGCTGCAGATATTCCTACATGGAACAATTTTGAAGGAGAAGCGAAAGTTTATAAAAACACAGTAGACTTTTTAGCTAAACGTGGAGATTTAGTTATATTCAACAGAAATTACGGTGGCGGTTATGGACACGTCGGCATCGTTATAAAAGCGACACTAGATTACATAGTGGTCATAGAACAAAATTGGCTTGGCGGTGCTTATTGGACACCACCAGAAGTAACTACACGTCGCACACATGGCTATGATTTTCCTATGTTTTTTATACGCCCCTACTTTGCAAAAGAAACGAAAACAAACGCTGTTAAAAGTAAAATGACACCTAAGAAAAAACCTAAAATGAACAAAGGTAAGAAAATATTACTTGTAGCCGGACATGGTAAAGGTGCTTATTCAAACGATCCGGGTGCAGTAGCTAATGGATATAATGAGCGCGATTTCAACAGAAAAGAAGTTATACCTAGAGTTAAGAAATATCTTGAGAGTGTAGGTAACACTGTCGTTCTATATGGTGGTAAGAAAATGAACCAAGATTTATATCAAGACACGTTATACGGTCAAAGGGTAGGAAATTATAAAGATTACGGTTTATATTGGGTTAAAAACAATGTTAAACCTGACGCGATTGTAGAATTTCATCTCGACGCTGCAAGCCCTAAGGCTAGTGGCGGTCATGTTATAGTAAGTGATAAATTCCCTGCCGATGATATAGACAAAGCATTGTCTAGTACATTAGATAAAACAGTAGGAAAAATAAGAGGTGTTACACCTAGAAATGATCTATTAAATGCAAATGTTACTGGATCATTAAACTTAAACTACAGATTGATAGAACTAGGTTTTATAACATCTAAAAAAGATATGAACTACATCACGAAAAATATTGATGACTTTACTAAAAGAATTGCAGAGGCAATCAACGGTAGACAGATCGAAGCGCCAAAGAGCAAACCTTCTAAAGCTAAAAATACATGGAATTGGTCGGGTACTTTCTACCCTAATGCGCCTAAAGAAGGTATTAGAGTTAGAAGATCGCCCGGCTTAAATGGTGCTATTGTCGAAAGTGGTTCGTGGTTATACCGAAAAACAGATTGGGTTAAATTTGATAGAGTTATCAAAAAGGATGGATATTGGTTTATTAGGTTTAAATATCAAGCGCCGGGATCTAGCAATAAACACTTCTACTGTGCAGTATGCAAAATTACCGATGAGCAACAAAAAATAAAAAACGAGAAATATTGGGGAACCATAGAGTGGAAATGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7e47k) rather than this protein.
PDB ID
7e47k
Method AlphaFoldv2
Resolution 88.88
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50