Protein

Protein accession
A0A8T8IUZ2 [UniProt]
Representative
7m5Au
Source
UniProt (cluster: phalp2_35332)
Protein name
Lysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MRELDWTAGGVNSSSRYGAAVRLFVLHTQEGGGTAESLARYLQNPNSGVSYHYTGDDASDTIVDVVDTDRASWSVMDANPFTINACFAGSRASQSRAEWISKFSKTMDAFARLFVQDAAKYNPLEPRVIDYADVSRGRAGGTDHNGITVGLRIGDHTDVGRNFPWDIFMGMVARHAQGVDIPVVVNMIDAMAKVAAAWIGARKTKGENVTPDGRGRWAEFENGYIYWTPTTGARAIPTNIFETWAELGYERGPLGYPVADHTVLPVEGDPKVGDVQAFEGGTIYRKYGHLQGFYVHGAIGETWKRQGFEKSRWGWPTSNETAIQGGAYQEFEGGRITWSADGTMGLVPMDGPDEIVPGPAH
Physico‐chemical
properties
protein length:361 AA
molecular weight:39408,3 Da
isoelectric point:5,31
hydropathy:-0,39
Representative Protein Details
Accession
7m5Au
Protein name
7m5Au
Sequence length
365 AA
Molecular weight
39730,32440 Da
Isoelectric point
4,83662
Sequence
MTVQEIDRTGETQNYSSRWGARIVWFALHTEEGGSNHDPERLHDWMKRNSVSYHYLAGAGRLLGIVDTDYGSWSAGDANPRTINLVFVGSRAAMSRQQWLDEFADDIDHAAWVFVRDAKKYDPLDPVVLGQDYDAIGAGRSGGIDHSGITYGLGIGDHTDVGPNFPWDVFEDAVEKYVEGYVPPVVVPAPTAIDAEALIAKAWIGARITAGEESTPDGRGRYARFENGAIYWSPSTGAWAVPSTVLTTWAERLWEAGALGYPIGRHAVLTGADGRPVGDVQGFEGGAIYRRYGQPGAVVTGRIRERWNRSGFENGPLGWPLSDEVEVDGGGRVQEFEHGRIAWSPEGTTALTPVGGPDQVVPDPH
Other Proteins in cluster: phalp2_35332
Total (incl. this protein): 49 Avg length: 385,1 Avg pI: 5,79
Protein ID Length (AA) pI
7m5Au 365 4,83662
1hQus 369 5,34385
1mpSu 373 5,30515
1mwY2 363 6,55356
3dMHd 351 4,62723
3dMrH 577 4,78365
3glLC 563 5,17163
4LB47 386 4,82327
6EJyM 357 5,33220
6SUip 410 5,03715
6TbEC 571 4,99765
72ug9 340 8,59758
75u1G 355 5,59497
75u81 566 4,94138
7AVuK 356 5,07341
7BKou 362 4,94297
7BN22 374 5,28656
7Qd8c 362 6,39538
7cclH 367 5,14497
7lGJ4 353 4,95081
7lGMx 355 4,95638
7mBdY 374 5,45696
7mBgD 374 5,37034
7styw 356 5,14452
7ukv3 315 5,38574
7vHjR 350 5,49152
7vaWP 374 5,45702
7vaZ4 374 5,28065
7vnjl 374 5,36022
7x5gl 367 5,47686
7yPm4 355 5,35255
7yyAZ 367 5,49260
7zGCz 581 4,70311
8HMS8 368 5,41684
8L0tj 359 5,42428
8MgYI 351 8,80253
QPe6 358 5,62242
f7T 370 6,08395
A0A1C9EI81 368 5,41684
G9FI08 359 5,42428
A0A4D6T682 375 7,25058
A0A9E7U1C2 368 7,27371
A0AA47KYG6 362 6,45943
A0A9E7LBL8 365 5,45264
A0A9E7Q399 368 8,29497
A0A9E7QK23 368 8,29497
A0A9E7TRP3 368 8,29497
A0AA96GQ65 368 8,29497
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_28062
7ebmV
 12 52,7% 364 1.483E-163
2 phalp2_30754
7C7wA
 28 48,5% 367 7.269E-160
3 phalp2_30716
7i7AZ
 2 38,4% 354 1.655E-94
4 phalp2_10392
1NTeW
 11 26,2% 240 1.616E-14

Domains

Domains [InterPro]
Unannotated
LGFP
Representative sequence (used for alignment): 7m5Au (365 AA)
Member sequence: A0A8T8IUZ2 (361 AA)
1 365 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF08310

Taxonomy

  Name Taxonomy ID Lineage
Phage Nocardia phage KYD2
[NCBI] 		2829800 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MW654182 [NCBI]
CDS location
range 20583 -> 21668
strand -
CDS
ATGCGTGAACTCGACTGGACAGCGGGCGGCGTCAACTCCAGCAGCCGGTACGGCGCGGCCGTTCGCCTGTTCGTACTCCACACCCAGGAAGGCGGCGGCACGGCGGAGAGCCTGGCCCGCTACCTCCAGAACCCCAACAGCGGGGTGTCGTACCACTACACCGGCGACGACGCTTCCGACACCATCGTGGATGTGGTGGACACCGACCGCGCCAGCTGGTCGGTCATGGACGCCAACCCCTTCACGATCAACGCCTGTTTTGCGGGCAGCCGCGCCAGCCAGTCCCGCGCGGAGTGGATCAGCAAATTCAGCAAAACCATGGACGCCTTCGCCCGGCTGTTCGTCCAGGACGCCGCGAAGTACAACCCACTGGAACCGCGCGTCATCGACTACGCCGACGTGAGCCGGGGCCGCGCCGGTGGCACCGACCACAACGGCATCACGGTGGGCTTGCGCATCGGGGACCATACCGACGTCGGCCGGAACTTCCCGTGGGACATCTTCATGGGCATGGTGGCCCGGCACGCCCAGGGCGTGGACATCCCGGTGGTGGTGAACATGATCGACGCCATGGCGAAGGTGGCAGCGGCCTGGATCGGCGCGCGCAAGACCAAGGGGGAGAACGTCACCCCGGACGGCCGGGGCCGGTGGGCCGAATTCGAGAACGGCTATATCTACTGGACGCCGACCACCGGCGCGCGGGCCATACCCACGAACATCTTCGAGACCTGGGCGGAACTGGGCTACGAGCGCGGCCCCCTGGGCTACCCCGTGGCAGACCACACCGTATTGCCGGTGGAGGGCGACCCGAAGGTGGGCGACGTCCAGGCATTCGAGGGCGGCACCATCTACCGCAAGTACGGTCACCTCCAGGGCTTCTACGTCCACGGCGCGATCGGTGAGACCTGGAAGCGCCAGGGCTTCGAGAAGAGCCGCTGGGGCTGGCCGACCAGCAACGAAACCGCCATCCAGGGCGGCGCATATCAGGAATTCGAGGGCGGCCGGATCACCTGGTCCGCCGACGGAACCATGGGCCTGGTGCCCATGGACGGGCCGGACGAAATTGTCCCCGGCCCGGCGCACTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7m5Au) rather than this protein.
PDB ID
7m5Au
Method AlphaFoldv2
Resolution 93.15
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50