Protein

Protein accession
A0A8S5VKL5 [UniProt]
Representative
5W5a2
Source
UniProt (cluster: phalp2_5916)
Protein name
Muramidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSDSALVGYTAISPNCNRPRSQPISKITVHHMAGNMTLESFGALVSRPSRQMSANYAIESSGRIGLFCHETDRSWCSSSPWNDQRAITIEVANDGGAPDWHISDKAYAALLDLCTDICRRNGIKELTYTGDKNGSLTMHCFYAATACPGPYLKSKFPDIAAQVTTRLKDDETDAAPAKTQEQTFIDVMVEKCRERCLSAHLLPSLCIAQACLESTYGTSELAVQANNLFGIKASNWTGKVYNKQTKEWDGSKYITITAGFRAYDTMIACVEDYIKKLTTMPRYSNLVGCTDINKACEYIRADGWATSPTYTSSLLAVVKQFNLTRYDAAIKEDKPAAPTKQEVWLDHVVLPNAAAMEFYLIAKKYGLDNDKAYHAKYVKE
Physico‐chemical
properties
protein length:380 AA
molecular weight:42130,4 Da
isoelectric point:7,04
hydropathy:-0,33
Representative Protein Details
Accession
5W5a2
Protein name
5W5a2
Sequence length
392 AA
Molecular weight
43224,45870 Da
Isoelectric point
7,46884
Sequence
MKNFPTAKETTTMSDSALAVYTAISPNCNRPRSQPISKITVHHMAGNTTLEAFGSIVGKASRQMSSNYAIDSNGRIGLFCHEADRSWCSSSPWNDQRAVTIEVANDGCAPDWHISDKAYSALLDLCTDICRRNGIKELTYTGDKNGSLTMHCFYAATACPGPYLKSKFPDIAAQVTTRLKGDVADAAPAKTQEQTFIDVMAEKCRERCLSAHLLPSLCIAQACLESAYGTSDLAVQANNLFGIKASNWTGKVYNKQTKEWDGSKYITITAAFRAYDTMVACVEDYIKKLTTMSRYSNLVGCTDINKACEYIRTDGWATSPTYTSSLLAVVKQFNLTRYDAAIKEDKPAAPTHQEVWLDHVVLPNAAAMEFYAVAKKYNLDNDRAYHAKYVEG
Other Proteins in cluster: phalp2_5916
Total (incl. this protein): 62 Avg length: 375,5 Avg pI: 7,30
Protein ID Length (AA) pI
5W5a2 392 7,46884
3qoOt 379 7,49737
3t3ea 380 7,85968
3tGAa 381 8,27692
3tihN 379 7,48430
4VEXY 349 7,03874
5LBol 349 6,70015
5LJPj 384 7,85749
5MfO0 375 8,09060
5Mmlp 380 7,50749
5Nsw8 380 7,48236
5OISN 380 6,74351
5OMqX 381 6,50297
5Px3d 380 6,50655
5PzT2 392 7,47981
5QUL7 350 6,00245
5SUdd 392 6,83934
5T29O 381 8,27692
5U8ym 380 7,06534
5Xxpl 380 7,49788
5YCok 349 6,44949
5YVIE 381 8,41230
5Zt7Q 381 8,09692
64fZ4 349 6,45085
66Et4 324 6,86117
67C25 380 7,09302
68AKO 380 7,48208
68AMy 380 7,48469
68ANq 380 8,28788
68rkB 348 6,38861
68ztZ 381 7,43758
697de 380 6,74261
6Z571 379 7,86406
6d7qL 380 8,27486
6hJlo 380 7,09165
6i07M 349 7,00435
6iXy9 381 6,74300
6iaCZ 379 7,49873
6jftS 381 7,49589
6jp8l 349 6,69850
6lEWz 392 7,48265
6mo1C 379 7,48430
6oed3 380 7,49612
6ojMX 349 6,65325
6p8IB 380 7,09302
6tRNy 380 7,49743
6tzzx 380 7,49726
6uVNA 380 7,48361
6v1XV 380 7,09205
6w5k0 392 6,31614
6w6QP 380 7,49635
6wjFU 380 7,49521
7W1xj 380 7,06522
86NHe 381 7,49623
87tIN 380 7,48316
88cIM 379 7,06426
88zgp 381 7,06369
8cFhD 375 8,08648
8fe7y 381 8,27692
8m3iO 380 7,09165
z5Bd 380 6,78143
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_25651
4k5ro
 34 39,2% 341 3.208E-60
2 phalp2_5251
813lL
 211 32,0% 486 1.509E-59
3 phalp2_21764
3VDPY
 2 35,8% 377 4.545E-58

Domains

Domains [InterPro]
Ami2
GLUCO
Disordered region
Representative sequence (used for alignment): 5W5a2 (392 AA)
Member sequence: A0A8S5VKL5 (380 AA)
1 392 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510, PF01832

Taxonomy

  Name Taxonomy ID Lineage
Phage Ackermannviridae sp
[NCBI] 		2831612 Ackermannviridae >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK035262 [NCBI]
CDS location
range 14618 -> 15760
strand -
CDS
ATGAGTGATTCCGCACTGGTAGGCTATACCGCCATCAGCCCCAACTGCAACAGACCCCGCAGCCAGCCCATCAGCAAGATTACCGTTCATCATATGGCTGGTAACATGACGCTTGAATCTTTCGGCGCTCTTGTCAGTAGACCCTCGCGCCAGATGAGCGCAAACTACGCCATAGAATCCAGCGGTCGTATCGGGCTGTTCTGCCACGAGACAGACCGTTCTTGGTGCAGTTCGTCGCCGTGGAACGACCAGCGGGCTATTACGATCGAGGTCGCCAACGACGGCGGTGCGCCGGACTGGCACATCAGCGACAAGGCCTATGCGGCGCTGCTTGACCTCTGCACCGACATCTGCCGCCGAAACGGCATCAAGGAGCTGACCTACACCGGCGATAAAAACGGTTCTCTCACGATGCACTGCTTCTACGCCGCCACGGCCTGCCCCGGCCCCTACCTCAAGAGCAAGTTCCCCGACATTGCGGCGCAGGTCACAACGCGCCTGAAGGACGACGAGACCGACGCTGCACCCGCCAAAACGCAGGAGCAGACGTTCATCGACGTGATGGTCGAGAAGTGCCGGGAGCGCTGCCTGAGCGCCCATCTGCTGCCGTCGCTGTGCATTGCGCAGGCTTGCCTTGAAAGCACCTACGGCACCAGCGAGCTGGCTGTTCAGGCCAACAACCTGTTCGGCATAAAGGCGAGCAACTGGACAGGCAAGGTCTACAACAAGCAGACAAAGGAGTGGGACGGCAGCAAGTACATCACCATCACGGCGGGCTTCCGCGCCTACGATACGATGATCGCCTGCGTCGAGGACTACATCAAAAAGCTCACGACGATGCCGCGCTACTCGAACCTTGTCGGCTGCACCGACATCAACAAGGCCTGCGAGTACATCCGCGCCGACGGCTGGGCGACAAGCCCGACATACACGTCGAGCTTGCTGGCGGTCGTGAAGCAGTTCAATCTGACTCGGTACGATGCCGCTATCAAAGAGGACAAGCCCGCCGCGCCGACAAAGCAGGAAGTGTGGCTGGATCACGTCGTCCTGCCCAACGCTGCGGCGATGGAGTTTTATCTCATCGCCAAGAAGTACGGTCTGGACAACGACAAAGCCTACCACGCTAAGTATGTGAAGGAGTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0004040 amidase activity molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (5W5a2) rather than this protein.
PDB ID
5W5a2
Method AlphaFoldv2
Resolution 85.57
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50