Protein

Protein accession
A0A8S5VIW8 [UniProt]
Representative
7onrw
Source
UniProt (cluster: phalp2_15556)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MHFHLPHRTSEHFGEHRSAFARAFGKHVSFVLHPRCEMSIVERIVAYGHGALNPSYFCVHSTANVGATAANHVSYWSNNPDYAVHLVSDWNTCYHTVPYDRLCWQVGNGNRFVEGIEICEATNRDDFARGIKIAADVCRERLSARGWGVDRLITHKRAAEIWGGSDHTDPIPYFSRWGYSWEEFVNLVENGDENMNPDEIWSFDNNGDPSERNAWRRLCDVHEAVSAWYYGQGGNQGLLTNVYDTNAKVTQMQVTLAAQTEAIKTLAESVGADPSAIADAVAAAVKEKLESINLEVTVD
Physico‐chemical
properties
protein length:299 AA
molecular weight:33500,7 Da
isoelectric point:5,47
hydropathy:-0,40
Representative Protein Details
Accession
7onrw
Protein name
7onrw
Sequence length
264 AA
Molecular weight
29290,95100 Da
Isoelectric point
4,98833
Sequence
MSIIQERIVNNGHGGLSASFFCVHSTANPGATAANHVSLWSRDYEYAVHLVSDWNEAYHTVPYDRLCYQVGNGNGYVEGLEICEATNADDFVKGIQIAAQVVRERLAAHGWGVDRLITHNDASQRWGGSDHTDPLPYFARFNYTWQDFVNLVQDSTATISTNAASADTNNWKDNNMFMVETTTPWGSTAYALLGEVTGARALTDIEALGYAQGLTTHGKVNFDIYNMLISQAWQRHNDFLTAMGKEVTESVEEATQRIVDATKR
Other Proteins in cluster: phalp2_15556
Total (incl. this protein): 11 Avg length: 263,9 Avg pI: 5,57
Protein ID Length (AA) pI
7onrw 264 4,98833
3kJLW 262 4,80843
3uVME 262 5,03340
7Rcft 264 5,08075
7ontJ 267 5,18664
7onva 264 4,98833
813or 252 9,25826
8hOgR 267 5,10206
8pdfF 238 6,12999
8pqNB 264 5,17379
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_10073
7zc1O
 6 59,7% 179 1.194E-73
2 phalp2_40115
87yor
 2 56,1% 180 7.863E-73
3 phalp2_32212
71H4R
 9 43,4% 191 1.693E-50
4 phalp2_7211
3lM9H
 3 29,0% 203 5.488E-18
5 phalp2_11198
68WMu
 78 24,2% 210 2.494E-14
6 phalp2_40199
2cSYZ
 15 20,8% 192 8.629E-06
7 phalp2_22201
6VaYI
 26 25,0% 204 4.834E-05
8 phalp2_14323
3WMg9
 12 21,4% 177 2.024E-04
9 phalp2_2999
1dx4C
 16 21,9% 232 3.584E-04
10 phalp2_26646
2dQ36
 4 21,0% 195 8.440E-04

Domains

Domains [InterPro]
Unannotated
Unannotated
Representative sequence (used for alignment): 7onrw (264 AA)
Member sequence: A0A8S5VIW8 (299 AA)
1 264 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage Podoviridae sp. ct9H612
[NCBI] 		2825226 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK016274 [NCBI]
CDS location
range 14829 -> 15728
strand +
CDS
ATGCACTTTCATCTGCCTCACCGAACTAGTGAGCATTTTGGAGAACATCGCTCTGCTTTCGCCAGAGCTTTCGGAAAACACGTTTCTTTCGTACTTCACCCGAGGTGCGAAATGAGCATCGTTGAACGGATAGTTGCCTATGGTCATGGTGCGCTGAATCCAAGCTATTTCTGCGTGCATAGCACGGCGAACGTCGGTGCCACTGCTGCGAATCATGTTTCATATTGGTCGAACAATCCCGATTATGCGGTTCATCTGGTTTCGGATTGGAACACGTGCTATCACACGGTGCCATACGACCGCCTATGTTGGCAGGTTGGAAACGGCAATCGCTTTGTCGAGGGAATTGAGATTTGCGAAGCGACCAACCGTGATGACTTCGCAAGGGGCATAAAGATTGCCGCCGACGTGTGCAGGGAAAGGCTTTCCGCTCGTGGTTGGGGAGTGGACAGGCTTATCACGCACAAGCGAGCCGCCGAGATATGGGGCGGCAGCGACCACACAGACCCGATACCCTATTTCAGCAGATGGGGTTACAGTTGGGAAGAGTTTGTAAATCTGGTAGAGAATGGAGACGAGAACATGAATCCTGATGAAATTTGGAGTTTTGACAATAACGGCGACCCCAGTGAGCGCAACGCATGGCGCAGGCTGTGCGACGTGCATGAAGCGGTCAGCGCATGGTACTACGGACAGGGCGGCAACCAAGGTCTGCTGACCAACGTGTACGACACGAACGCCAAGGTGACGCAGATGCAAGTAACGCTGGCAGCGCAGACCGAAGCTATCAAGACGCTTGCAGAATCCGTAGGCGCCGACCCTAGCGCGATTGCGGACGCGGTTGCTGCTGCTGTGAAGGAGAAACTTGAATCCATAAATCTTGAGGTGACGGTTGACTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7onrw) rather than this protein.
PDB ID
7onrw
Method AlphaFoldv2
Resolution 88.49
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50