Protein

Protein accession
A0A8S5UAY4 [UniProt]
Representative
5v6U
Source
UniProt (cluster: phalp2_30764)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSESSLATYVHYSPNCTKPRQGTIKGVAIHCTAGGRNLPARNFADMNRFAVEQKNGASCHYVVGGDGSIAQVCREENRAWCTSNPIDHQLVTIEVASDADGDCKCNMAALNSLIKLLVDICQRNNIPRLLWRGDKGLMGQWDKQNMVVHRWTANKACPGDYLYNKHAVIAQTVNNRLGAETEDDMDIKKIIEQLTPEMCYAIVTEAMAYADNLPEPEWSKKEGDFLNLKHRGIMDGTGPERFVKRDELAAVLGRMELIQATEV
Physico‐chemical
properties
protein length:263 AA
molecular weight:29285,1 Da
isoelectric point:6,00
hydropathy:-0,41
Representative Protein Details
Accession
5v6U
Protein name
5v6U
Sequence length
494 AA
Molecular weight
55473,63940 Da
Isoelectric point
9,32124
Sequence
MALTAQQTKFVNDILPLIQKYAPKYDILLPGVVLMQAVKESNFGTSKKAQHHNYFGLKYRPNRCPSSNGTFTDSSKEQNPDGSYKDIKDRWFTFPDMESGVKGYFDFTNIKSYAELKKETNPEKYLKVLEKVKYFTSFSYVETALKKYYEYGFDKYDKVSAVSSAVTSTTPKTSEISSQISGEFSNSSLVTYKNIAPHKTSPRNHKIDTITIHCYVGQVTAKQGCDMFAKTSRKASCNYVVGKDGSIGLCVDEKDRSWCSSNAANDNRAITIEVASDTVTPYKVTNEALNALIELCADICRRNKIKKLLWKGDKSLIGQVDKQNMTVHRWFAAKACPGDYLYNLHGEIAERVNQKLGHGQVIIKENKEEKTPEISVKIPEKTGIKYIVQRGDTLTIIAKKFSTTIEKIAEINKIADINKIRTGQTLIVRTDYEKKTVKTRGSNLNVRKGPSANESIIGKLRNGSSVNVLEKTNEVWSKVEINGLVGYVCSSYLN
Other Proteins in cluster: phalp2_30764
Total (incl. this protein): 28 Avg length: 454,9 Avg pI: 7,19
Protein ID Length (AA) pI
5v6U 494 9,32124
1399D 495 8,21284
3PZL7 460 9,18347
3TDkr 444 6,14437
3WzTb 486 8,67005
3ZskS 431 5,63822
3ZzY2 453 6,34695
3dPyu 449 7,54585
3dZbH 447 5,81153
3e0KV 442 5,85916
3fUZ2 434 5,74321
3gXv5 484 8,87538
3h0iS 435 5,82147
3h2Dr 454 6,34581
3iA1F 430 6,55606
3iBi3 442 5,99972
3iyL3 460 5,93839
40lNh 433 5,80453
4L4BY 454 6,34001
4kr6D 454 6,55691
5C0vH 433 9,18779
5C16E 500 9,23743
6ndWt 550 8,22451
6t64y 550 8,22212
7JCb1 486 8,64381
7LkOs 454 5,94828
8bs9s 419 9,07278
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_22435
KIGS
 311 46,6% 354 5.148E-138
2 phalp2_20828
6lIKR
 83 36,0% 524 9.046E-118
3 phalp2_38692
MSLD
 8 29,6% 358 2.819E-58
4 phalp2_1516
23ABA
 1 36,6% 325 5.192E-58
5 phalp2_21762
3TRfz
 37 17,0% 386 3.536E-19
6 phalp2_21648
2Vbrp
 10 18,6% 387 8.270E-19

Domains

Domains [InterPro]
GLUCO
Ami2
LysM
SH3_3
Representative sequence (used for alignment): 5v6U (494 AA)
Member sequence: A0A8S5UAY4 (263 AA)
1 494 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01476, PF01510, PF01832, PF08239

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ct8Cp41
[NCBI] 		2825358 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK016059 [NCBI]
CDS location
range 14107 -> 14898
strand -
CDS
ATGAGTGAATCCAGCCTGGCTACCTACGTCCACTACTCCCCCAACTGCACCAAGCCCCGGCAGGGGACCATCAAGGGTGTGGCGATCCACTGCACCGCCGGAGGGCGGAATCTGCCAGCCCGCAACTTTGCGGATATGAACCGCTTTGCCGTGGAGCAAAAAAACGGGGCTAGTTGCCACTATGTCGTTGGCGGGGACGGCTCCATTGCCCAGGTGTGCCGGGAGGAAAACCGAGCTTGGTGTACCTCTAACCCCATCGACCACCAGCTTGTAACCATCGAGGTTGCCAGCGATGCCGACGGGGACTGCAAATGCAACATGGCGGCGCTCAACAGTCTCATCAAGCTGCTGGTGGATATCTGCCAGCGGAATAACATTCCCCGCCTGCTGTGGCGGGGGGATAAGGGCTTGATGGGGCAGTGGGATAAGCAAAACATGGTGGTGCATCGGTGGACGGCGAACAAAGCCTGTCCGGGGGACTACCTGTACAACAAACACGCGGTGATTGCCCAGACCGTAAACAACCGGCTGGGGGCGGAAACGGAGGATGACATGGACATCAAAAAAATCATCGAACAGCTCACGCCTGAAATGTGCTACGCTATCGTAACTGAGGCCATGGCCTACGCCGACAACCTGCCGGAACCGGAGTGGTCGAAAAAAGAGGGCGATTTCCTGAACCTGAAACATCGCGGCATCATGGATGGAACGGGGCCGGAGCGATTTGTCAAGCGGGATGAGCTGGCCGCTGTGCTGGGCAGAATGGAACTGATTCAGGCCACCGAGGTTTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (5v6U) rather than this protein.
PDB ID
5v6U
Method AlphaFoldv2
Resolution 84.40
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50