Protein

Protein accession
A0A8S5U3B5 [UniProt]
Representative
4k5ro
Source
UniProt (cluster: phalp2_25651)
Protein name
Muramidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MAYTNSSMVAYTKLSPNHSGQRTHSIDRITPHCVVGQCTAEGLGDWFYKASTQASSNYGIDKDGRVGMYVEEKNRSWCSSSNANDQRAITIECASDTTEPYAFRDIVYQTLIKLCVDICKRNGKTKLLWLGDKDKTLAYEPKSGEMVLTVHRWFANKSCPGNWMYARMGDLAEKVTAALGSGTGGTDGATTTQGTQASAFSSLSESDVVKSVGTLFTADQKKTGILASVSMAQFILESGYGKSELAQNANNVFGMKCSLSGNTWSGSTWDGTSKYTKQTKEQNADGSYTTITADFRKYPCVEDSISDHSAYLLGAKNGSKLRYDGLKGCTDYRKAAQIIKDGGYATSLTYVQNLCSIIERWNLTQFDVKESETAIAWYRVRKTWADSKTQKGAYKILEYAKKCADANPGYSVFDVNGVNIYTPNTTSDSTAAVPFLVKVSISDLNIRKGPGTDYTRTQYIPVGVYTIVEVKSGKGSTAGWGRLKSGAGWISLDFATRV
Physico‐chemical
properties
protein length:498 AA
molecular weight:54377,4 Da
isoelectric point:8,83
hydropathy:-0,43
Representative Protein Details
Accession
4k5ro
Protein name
4k5ro
Sequence length
338 AA
Molecular weight
37033,35370 Da
Isoelectric point
8,89839
Sequence
MAYTNSSMVAYTKLSPNHSGQRTMAIDRITPHCVVGQCTAEGLGDWFAKSSTQASSNYGIDKDGRVGMYVEEKNRSWCSSSNANDQRAITIECASDTTEPYAFKDVVYQTLIKLCIDICKRNGKNKLIWFGDKDKTLNYAPKNGEMILTVHRWFANKSCPGNWMYARMGDLAEKVTKALQGSSDSSGGSTTKGTQASVLKDLSEADAIKKVGALFTADQKKSGILASVSLAQFILESGYGKSELAQNANNIFGMKCSLSGNTWSGSSWDGKNKYTKKTQEQHADGSYETITADFRKYPCIEDSIADHSAYLLGAKNGKKLRYDGLKGCTDYKKAVQII
Other Proteins in cluster: phalp2_25651
Total (incl. this protein): 34 Avg length: 481,0 Avg pI: 8,71
Protein ID Length (AA) pI
4k5ro 338 8,89839
137fl 505 8,56741
13E0t 550 8,93727
1cuKQ 466 8,75830
1k39V 502 8,90142
1m1yc 502 9,02295
1mcwm 507 8,39000
2Vdc9 529 9,03326
2lsT1 501 8,81014
2mx1Q 505 8,67830
3d8cm 296 7,49976
3k0X1 506 8,97318
3l7bH 500 9,04132
3lm1I 503 8,87009
3myaa 503 8,64548
3pBRr 500 9,07104
3pHXS 503 8,49592
3qqk7 505 8,53318
3r2bx 505 7,81668
3uEf0 505 8,97305
3uK6U 505 8,84211
3w16I 506 8,42333
3weOt 505 8,23385
41g1N 317 6,98014
6YGpz 505 8,74664
76rhu 414 9,57054
7q2ME 437 9,12713
7vNlA 412 9,81700
7znug 500 8,25552
8ovBN 505 8,24655
xC2l 502 8,85256
ynmp 508 8,81007
A0A8S5Q8Y7 509 9,50826
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_3823
6s14g
 1 74,6% 213 6.944E-112
2 phalp2_21764
3VDPY
 2 42,5% 322 1.667E-78
3 phalp2_37260
40eca
 5 51,1% 209 2.227E-75
4 phalp2_5916
5W5a2
 62 37,3% 340 4.369E-62

Domains

Domains [InterPro]
Ami2
GLUCO
Representative sequence (used for alignment): 4k5ro (338 AA)
Member sequence: A0A8S5U3B5 (498 AA)
1 338 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510, PF01832

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctSA812
[NCBI] 		2825508 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK016000 [NCBI]
CDS location
range 7974 -> 9470
strand -
CDS
ATGGCATACACAAACAGTTCAATGGTGGCTTACACCAAACTCAGCCCGAACCATTCCGGACAGCGGACACATTCCATAGACCGCATCACTCCTCACTGCGTGGTCGGTCAATGTACGGCAGAGGGACTTGGAGACTGGTTTTATAAAGCCAGTACCCAGGCATCCTCGAATTACGGCATCGACAAAGACGGCCGTGTCGGAATGTATGTGGAGGAGAAGAACCGCTCCTGGTGTTCTTCCTCCAATGCCAATGACCAGAGGGCGATCACCATCGAGTGCGCATCCGATACCACGGAGCCGTATGCGTTTCGCGACATCGTTTATCAGACGCTCATCAAGCTGTGCGTGGATATCTGCAAGCGTAACGGAAAGACGAAGCTCCTGTGGCTCGGCGATAAGGATAAGACGCTTGCTTACGAACCGAAGTCCGGCGAGATGGTGCTGACCGTCCATCGGTGGTTCGCCAATAAGTCTTGTCCCGGCAACTGGATGTATGCCAGGATGGGTGATCTTGCGGAAAAGGTCACGGCGGCTCTCGGCAGTGGTACCGGGGGTACCGATGGTGCCACTACTACACAGGGAACACAGGCTTCCGCCTTTTCTTCGCTTTCAGAGTCGGATGTTGTAAAGAGTGTGGGGACATTGTTTACGGCAGACCAGAAGAAAACGGGCATCCTCGCATCGGTCTCGATGGCACAGTTCATCCTCGAATCCGGCTACGGCAAGTCGGAGCTGGCGCAGAACGCCAATAACGTGTTCGGTATGAAATGCTCCCTCTCCGGCAATACCTGGAGCGGTTCGACCTGGGACGGAACGAGCAAATATACCAAGCAGACAAAGGAGCAGAACGCGGACGGCAGCTATACCACCATCACGGCGGACTTCCGCAAGTACCCGTGCGTGGAGGATTCCATTTCCGACCATTCCGCGTATCTGCTCGGCGCGAAGAATGGCAGCAAACTCCGCTATGACGGTCTTAAGGGGTGCACGGACTACAGGAAGGCGGCACAGATCATCAAGGACGGCGGGTATGCCACAAGCCTGACCTACGTTCAGAATCTCTGCTCGATCATCGAGCGGTGGAACCTTACGCAGTTCGATGTGAAGGAAAGCGAAACGGCTATCGCCTGGTATCGCGTCCGTAAGACCTGGGCGGATTCCAAGACGCAGAAAGGCGCTTATAAGATCCTTGAGTACGCCAAGAAATGCGCGGATGCCAATCCGGGATATAGTGTGTTCGATGTAAACGGCGTAAACATCTACACACCGAACACAACATCTGATTCCACGGCGGCGGTTCCGTTCCTCGTGAAGGTCAGCATTTCCGACCTAAATATCCGCAAAGGACCGGGGACGGACTACACAAGAACACAGTATATCCCTGTCGGCGTGTACACCATCGTGGAGGTGAAGTCCGGCAAGGGCTCGACCGCTGGTTGGGGGCGGCTTAAGAGCGGCGCGGGATGGATCAGCCTGGACTTCGCCACAAGAGTTTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0004040 amidase activity molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4k5ro) rather than this protein.
PDB ID
4k5ro
Method AlphaFoldv2
Resolution 93.70
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50