Protein

Protein accession
A0A8S5U2W8 [UniProt]
Representative
3lM9H
Source
UniProt (cluster: phalp2_7211)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKQRYRLRSRSAKCRMLRSHAPTSGSASQSTTSQRQVSPTTGGTTQAAQTQRMPISTGSPSSMNSRTERTTAMTVNSAVTDTLWGPNFDPGRPYGEPLGIVIHHWGADGQSHDAVAAYLARPDGNTSAHYVASGGRVTQIVHDYDRAWHCMGNNACTIGIECRPECDAADVETVAQLIAAIREEWGYLPLSGHQEHFPTECPGRWQARLDELDARALLIQGGGPAVPALADPDPGSLQVDGWWGPATTAALQAYLGTPVDGTVSSQDGAWRENLPAAGAGWDFENDPDGSQMVSALQARLGVPVDGILGPETIAALQARLGVPVDGYAGMATVAALQAHLNEGTL
Physico‐chemical
properties
protein length:345 AA
molecular weight:36503,1 Da
isoelectric point:5,31
hydropathy:-0,36
Representative Protein Details
Accession
3lM9H
Protein name
3lM9H
Sequence length
261 AA
Molecular weight
28375,19850 Da
Isoelectric point
5,31543
Sequence
MALNSAVTDTRWSPNYTPGRAAPLRDIVIHHWGTDGQDHDTVAGYLARANGNTSAHYVASAGRVTQLVSDTNTAWHCPGMNAGGIGIECRPECSDGDFETVAQLIAAIRTEWGYLPLSGHQDHYATACPGRWESRLEELDARAIAIQNGAPTGAVPSTSISDLIGDNMYIICTRTPWGEWAYALIHATVGGARAIDNTYGERTAYERLLGDAKVVEWDFYNLLVRQAWERHNAAVAAIRGGVREDIDAAVQRVIDATKKEA
Other Proteins in cluster: phalp2_7211
Total (incl. this protein): 3 Avg length: 299,3 Avg pI: 5,13
Protein ID Length (AA) pI
3lM9H 261 5,31543
Hr46 292 4,75347
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_13827
7cMO8
 12 50,0% 180 1.989E-39
2 phalp2_31988
59Np4
 130 40,0% 230 2.243E-35
3 phalp2_13682
65xN2
 64 40,6% 172 5.423E-30
4 phalp2_15294
1dl82
 2 35,2% 170 1.660E-24
5 phalp2_15556
7onrw
 11 30,7% 241 3.529E-16
6 phalp2_4921
6qvcZ
 45 30,3% 211 2.354E-10
7 phalp2_13210
2JwXt
 44 27,0% 218 1.986E-06

Domains

Domains [InterPro]
Ami2
Unannotated
Representative sequence (used for alignment): 3lM9H (261 AA)
Member sequence: A0A8S5U2W8 (345 AA)
1 261 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctcRb7
[NCBI] 		2825572 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015996 [NCBI]
CDS location
range 1998 -> 3035
strand -
CDS
ATGAAGCAAAGGTATCGTTTGCGAAGCCGTTCCGCAAAGTGCCGAATGTTGCGATCTCATGCGCCAACCAGCGGCTCCGCGTCGCAATCTACAACGTCACAACGACAGGTTTCACCTACTACGGGTGGAACGACACAAGCGGCGCAAACTCAGCGGATGCCTATTTCGACTGGGTCGCCGTCATCGATGAATTCAAGGACTGAAAGGACCACAGCCATGACCGTGAATAGTGCTGTCACCGACACGCTTTGGGGACCGAACTTTGACCCCGGTCGCCCCTACGGCGAACCGCTCGGCATCGTCATTCACCATTGGGGAGCAGACGGGCAGTCTCACGACGCCGTCGCCGCCTACCTCGCGCGCCCCGATGGGAATACATCGGCACACTACGTTGCCAGCGGCGGTCGCGTGACCCAGATCGTTCACGACTATGACCGTGCCTGGCACTGCATGGGTAACAACGCCTGCACAATCGGGATCGAGTGCCGCCCCGAGTGCGACGCCGCCGACGTCGAGACCGTCGCACAGCTGATCGCCGCGATCCGCGAAGAATGGGGATATCTGCCCCTATCTGGACATCAGGAACACTTCCCCACTGAATGCCCCGGACGCTGGCAGGCCCGGCTCGACGAACTTGACGCCCGCGCCCTCCTCATCCAGGGCGGCGGGCCCGCCGTGCCCGCGCTCGCCGATCCTGACCCCGGTAGCCTCCAGGTGGACGGCTGGTGGGGACCGGCGACAACCGCCGCCCTCCAGGCCTACCTCGGAACGCCCGTAGACGGCACCGTATCCAGTCAGGACGGGGCCTGGCGCGAAAACCTCCCCGCCGCCGGGGCCGGTTGGGACTTCGAGAACGACCCCGATGGATCGCAGATGGTTTCCGCCCTCCAGGCCCGCCTCGGCGTCCCCGTGGACGGCATCCTTGGCCCCGAGACTATCGCCGCCCTCCAGGCCCGCCTCGGCGTCCCCGTGGACGGATACGCGGGCATGGCGACCGTCGCCGCCCTGCAGGCCCATCTCAATGAAGGGACGCTCTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (3lM9H) rather than this protein.
PDB ID
3lM9H
Method AlphaFoldv2
Resolution 88.01
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50