Protein

Protein accession
A0A8S5S684 [UniProt]
Representative
5Pvnh
Source
UniProt (cluster: phalp2_11181)
Protein name
Peptidoglycan hydrolase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MEKQEFIKKIAAFVQKYAPQYGIKVHSPIIAQAILESGWGESKLSAKYHNYFGLKCGTKWTGPSVNMTTQEEYQPGVHTTIKDNFRVYGSMEEGVKGYFEFIQLARYQNLRDITDPQRYLETIKADGYATSSTYVENNMRLVHQYNLTQYDKEEVSMGRTAQDVLNVMRGWLGYSEANGKFRQIIDLYNSVKPLPRGYAVKYTDEWCDTTVSAAGIKAGCSDLIGRECGCEQHVKIFQSMGIWIEDGTITPIPGDIILYNWDQGYQPNNGYSDHIGFVESVSGNQITCIEGNKGEAVARRVLTVGNGNIRGYARPRYAAGGTPVQPSTPSKSITEVAKEVIAGSWGNGQDRANRLKAAGYNPDAVQAEVNRILGGQPSKPALKPITEVAKEVVAGKWGNGQDRINKLTAAGYNPNTIQAEVNRLVGGAAPKKSEDEIAKEVLAGKWGNGQDRINKLTAAGYNVQSIQNKVNRLAGGGKSVDTVAREVIQGKWGNGQDRVNRLRAAGFDPNAVQARVNQLL
Physico‐chemical
properties
protein length:520 AA
molecular weight:57159,7 Da
isoelectric point:8,97
hydropathy:-0,53
Representative Protein Details
Accession
5Pvnh
Protein name
5Pvnh
Sequence length
436 AA
Molecular weight
48070,54030 Da
Isoelectric point
7,95954
Sequence
MFYSYLILYYKEEFNMGATAQDVLNVMRSWLGFSEYNGKFKQIIDLYNSVLPLPRGYAVKYTDAWCDATVSAAAIKAGAQDIIGRECGCEQHIKIFKQKGIWIEDGTIRPEPGDVIVYNWGDSTQANDGYADHIGYVEYVSGNTITAIEGNKNEAVERRSLPVGWGYIRGYSKPKYDNSSSKPNPPQQPSKTITEIAEDVIKGVYGNGDTRKNAIESMGYDYYKVQKEVNRILSGKPSENTESTVKYTVKPNDTLSAIASRFNTTVNDIAQKNGIVDPNKIYPGQVLIIKKPTGSTNQESYKVKLIKEGQSEGNTFCGTSFSVDGIVGPNTKKLTVMCLQVALNKDYGAKLTVDGSFGPKTKAALGNHYVKFGETQWLATFVQVALYIHGYDPKGVEHPGHIGYGCDAAIGNYQSDHGLNPDRTAGKNTITSLCYK
Other Proteins in cluster: phalp2_11181
Total (incl. this protein): 15 Avg length: 369,7 Avg pI: 9,02
Protein ID Length (AA) pI
5Pvnh 436 7,95954
1FYkr 421 7,52039
1b06O 339 9,35232
1bA4H 339 9,18457
1bD4W 340 9,51852
1bD5e 340 9,38326
1dkEz 340 9,15304
1jKT1 339 9,32098
2jTSm 339 9,24066
3BTAQ 340 9,34136
3qY82 421 8,43055
6nyOC 339 9,33433
6trEU 339 9,36366
8qeFO 353 9,25787
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_29393
1dfbb
 105 41,3% 278 1.706E-55
2 phalp2_7368
4xoTh
 314 39,0% 302 4.887E-50
3 phalp2_12538
16lqa
 19 29,5% 416 3.881E-45
4 phalp2_35707
3PU5B
 16 25,3% 414 1.293E-29
5 phalp2_9136
6d0dy
 3 31,7% 299 8.808E-26
6 phalp2_10891
4yt2F
 36 30,8% 301 2.189E-24
7 phalp2_36036
5N9T1
 7 28,3% 356 7.173E-23
8 phalp2_33156
7DPYX
 1 28,1% 284 3.056E-22

Domains

Domains [InterPro]
CHAP
CW_7
LysM
Unannotated
Representative sequence (used for alignment): 5Pvnh (436 AA)
Member sequence: A0A8S5S684 (520 AA)
1 436 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01476, PF05257, PF08230

Taxonomy

  Name Taxonomy ID Lineage
Phage Caudovirales sp. ctaix4
[NCBI] 		2827635 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK032533 [NCBI]
CDS location
range 42969 -> 44531
strand +
CDS
ATGGAGAAACAAGAATTCATAAAGAAAATAGCGGCGTTTGTTCAGAAATACGCTCCGCAGTATGGCATCAAGGTACATAGCCCTATCATCGCCCAGGCAATCCTGGAATCAGGGTGGGGAGAAAGCAAGCTATCAGCAAAGTATCACAATTACTTCGGTCTGAAATGCGGAACCAAATGGACAGGCCCATCCGTAAACATGACAACCCAGGAAGAGTACCAGCCTGGAGTTCACACGACCATCAAGGACAACTTCAGGGTTTATGGATCCATGGAAGAAGGCGTGAAGGGATACTTTGAATTTATCCAGCTGGCAAGATACCAGAACCTTCGTGACATTACGGATCCGCAGAGGTACCTCGAAACCATCAAAGCAGATGGGTACGCAACAAGCTCCACATATGTGGAAAACAATATGAGACTTGTACACCAGTACAATTTGACACAATACGATAAGGAGGAAGTATCTATGGGAAGAACAGCACAAGACGTCCTGAACGTCATGAGAGGATGGCTGGGATACAGCGAAGCAAATGGCAAATTTAGACAGATCATCGATCTGTACAATTCCGTGAAACCTTTACCAAGAGGATATGCAGTGAAATACACAGATGAATGGTGCGACACAACCGTGTCTGCAGCGGGCATTAAGGCAGGATGCAGCGACCTGATCGGAAGAGAATGCGGATGCGAGCAGCACGTGAAGATTTTTCAGAGCATGGGAATCTGGATCGAGGACGGCACCATCACTCCGATTCCAGGAGACATCATCCTTTATAACTGGGATCAGGGATACCAGCCAAACAATGGATATTCTGATCACATCGGATTTGTTGAGAGCGTGTCAGGCAATCAGATCACCTGTATCGAAGGAAATAAAGGAGAGGCTGTGGCAAGACGTGTCCTCACAGTAGGAAACGGAAATATCAGAGGATATGCCCGTCCAAGATATGCAGCAGGAGGAACACCGGTACAGCCATCGACTCCTTCAAAGTCCATCACAGAAGTAGCGAAGGAAGTAATCGCTGGATCCTGGGGAAACGGCCAGGACAGAGCAAACCGCTTAAAAGCAGCGGGCTACAACCCAGATGCAGTTCAGGCAGAGGTGAATAGAATCCTCGGCGGACAGCCATCCAAACCGGCTCTTAAGCCAATCACAGAGGTAGCAAAAGAGGTCGTAGCAGGCAAGTGGGGAAACGGCCAGGACCGTATCAATAAATTGACTGCAGCGGGTTACAACCCAAACACTATCCAGGCAGAGGTGAACCGCCTCGTAGGCGGAGCGGCTCCAAAGAAGTCAGAAGACGAGATCGCAAAGGAAGTCCTCGCGGGCAAGTGGGGAAATGGCCAGGACCGTATCAACAAGCTGACAGCAGCAGGCTACAACGTTCAGAGCATCCAGAACAAAGTCAACCGGTTAGCCGGCGGAGGAAAATCCGTAGACACCGTAGCACGTGAAGTTATTCAGGGAAAATGGGGAAACGGACAAGACAGAGTAAACCGCTTAAGAGCAGCAGGATTCGATCCGAACGCAGTACAAGCTAGAGTAAATCAGTTATTGTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0004040 amidase activity molecular function None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (5Pvnh) rather than this protein.
PDB ID
5Pvnh
Method AlphaFoldv2
Resolution 85.85
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50