Protein

Protein accession
A0A8S5QZA0 [UniProt]
Representative
40d9r
Source
UniProt (cluster: phalp2_23993)
Protein name
Cell wall hydrolase autolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MNRWIGATKGSAKHAEILRIYNGHTPLARGYKMQTADAYCAATVSAAWIANGMAEYTGTECGVGKFVDIAKRKGIWVENDAYVPKLGDAVVYDWQDSSNYATTDNRGAPDHIGIVTQTGASAFIVTEGNMSGGRTGRRTMSVNGRYIRGFIAPDYDAIAKKIGGTSSGAGNKPVTPVATPSANTYTVRAGDTLFHIAAAHGTTVDALVQLNSIKNPDLIHVGQVLKLTGNAQYTVVAGDTLSKIAARYGTTVKAIADLNNIKNINLIHVGQKLTIPR
Physico‐chemical
properties
protein length:277 AA
molecular weight:29383,0 Da
isoelectric point:9,48
hydropathy:-0,16
Representative Protein Details
Accession
40d9r
Protein name
40d9r
Sequence length
334 AA
Molecular weight
35621,79860 Da
Isoelectric point
9,16510
Sequence
MTEQQLRQHVCDIINGWIGATKGSAKHLEILKIYNEHKPLAVGYTVKVTDAYCATTVSAAWIKAGIAEHTGTECGVNRFIRIAQDKGIWIENDAYVPKLGDAVVYDWQDTGAGDNRGDGDHIGIVTQPGSSSFVVTEGNTSGGKVATRTMQVNGRYIRGFIAPNYAAIAKALGGAGVPTENDPDKTTKSIEEIAKEVIAGKWGNGSERRTRLQAAGYAYSAVQAKVNELLGKTTEPAAEPAKPSTEAPAQDTGKKVLPAEKFDRGIAGTYTVKAAAGLNIRYGPGTAYGVIKSISKGTKVNNYGYYSIRGGVKWYYIRCGATVGFVSSVYLTKA
Other Proteins in cluster: phalp2_23993
Total (incl. this protein): 21 Avg length: 345,1 Avg pI: 8,29
Protein ID Length (AA) pI
40d9r 334 9,16510
138DH 422 9,09728
21wbw 512 5,57536
23P4P 495 5,37534
23bYB 339 9,37340
24Chh 330 9,27063
3TIhb 272 9,40402
3VKDC 272 9,27057
3Wyrg 309 9,30874
3ZR41 256 5,98238
3dQzc 434 4,99867
40jkW 297 5,68023
410v4 334 8,98304
4L0Eg 332 8,64871
4xEpP 437 8,64026
4xpAf 426 9,13577
4y5Gm 293 9,24272
4ynCi 293 9,24272
7q0IV 253 8,84682
grNW 330 9,42078
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_25915
5TtYr
 397 45,8% 336 2.533E-113
2 phalp2_24033
810r1
 150 41,2% 339 1.521E-96
3 phalp2_35905
7DH9G
 6 52,4% 242 1.663E-88
4 phalp2_6929
2LVGE
 3 42,8% 285 1.834E-86
5 phalp2_29393
1dfbb
 105 46,6% 208 1.400E-75
6 phalp2_2377
7JCYq
 91 34,4% 340 3.198E-74
7 phalp2_26927
4yq9J
 22 26,8% 376 3.811E-45
8 phalp2_29481
1Jfam
 8 27,5% 327 8.381E-44
9 phalp2_12732
7UP1W
 1 38,0% 218 8.592E-42
10 phalp2_15188
xzEU
 42 29,2% 294 7.148E-26

Domains

Domains [InterPro]
Unannotated
CW_7
Unannotated
Representative sequence (used for alignment): 40d9r (334 AA)
Member sequence: A0A8S5QZA0 (277 AA)
1 334 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF08230

Taxonomy

  Name Taxonomy ID Lineage
Phage Caudovirales sp. ctNZz8
[NCBI] 		2826772 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015770 [NCBI]
CDS location
range 27198 -> 28031
strand -
CDS
ATGAACAGATGGATCGGCGCAACAAAGGGAAGTGCGAAGCACGCAGAGATCCTGCGGATTTACAATGGACATACGCCGTTGGCGCGTGGCTACAAGATGCAGACGGCAGATGCCTACTGTGCAGCGACCGTCAGCGCGGCGTGGATCGCCAACGGAATGGCCGAGTACACGGGGACGGAGTGCGGCGTGGGCAAATTCGTGGACATTGCCAAGCGGAAAGGTATCTGGGTCGAGAATGATGCCTACGTTCCCAAGCTCGGTGATGCTGTCGTGTACGACTGGCAGGACAGCAGCAACTACGCCACCACGGATAATCGCGGTGCGCCGGATCATATCGGCATCGTAACGCAGACTGGTGCCAGTGCTTTTATCGTGACCGAGGGTAATATGTCCGGCGGTAGGACGGGCAGACGCACGATGTCTGTCAACGGGCGGTATATTCGCGGCTTCATCGCTCCCGATTACGACGCAATTGCAAAGAAGATTGGCGGCACATCCTCCGGCGCAGGAAACAAGCCCGTCACACCTGTTGCAACGCCCTCTGCGAATACTTACACGGTGCGCGCCGGTGATACCCTGTTCCACATTGCCGCGGCGCACGGGACGACTGTGGACGCGCTGGTGCAGCTCAACAGCATCAAAAATCCCGACCTGATCCATGTTGGACAAGTCCTGAAGTTGACAGGCAACGCGCAGTATACTGTCGTCGCAGGAGACACGCTTTCCAAAATCGCCGCCAGGTACGGCACGACCGTGAAAGCGATCGCCGACCTGAACAACATCAAGAACATCAATCTGATCCATGTTGGGCAGAAGCTGACTATTCCGAGGTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008932 lytic endotransglycosylase activity molecular function None (UniProt)
GO:0016787 hydrolase activity molecular function None (UniProt)
GO:0071555 cell wall organization biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (40d9r) rather than this protein.
PDB ID
40d9r
Method AlphaFoldv2
Resolution 84.96
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50