Protein

Protein accession
A0A8S5QR58 [UniProt]
Representative
1dRNc
Source
UniProt (cluster: phalp2_39893)
Protein name
D-alanyl-glycyl endopeptidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MAFKMRTSKPEAGNKYYITKASGGYSDAIKGSPTDKDCDVLSNCVGYAYGRFNEIGGYGYCKYLRPVNAENFIQYKGTALKTGQTPKLGACMVWQKGATLNGSDGAGHVAIVEKVVSDTEVYTSESGWGSSTPFWNKTRTKGNGNWGQGAAYKFLGFIYNPAVSDEKPAGTTPTPSTSGSTDEKTIWDYLLGKIGNEYGVAGLMGNLYAESCLRPNNLQNAYETRLGYTDASYTAAVDNGSYTKFGTDSAGYGLAQWTYHTRKKALLAFAQRKKKSIGDLNMQLEFMYKELSESYKGVLADLKSAKTVLAASNSVLTKFERPANQGAAVQSKRAEFGQKYYEKYAGKTVSSTPQETGKETTNMGYTNSSLVSYTKLSPNHSGQRTQAIDRITPHCVVGQCSVETLGNIFAPTSKQASCNYGIGVDGRVGMYVEEKNRSWCSSSAANDQRAITIECASDATEPYAFKDVVYNKLIELCVDICKRNGKNKLLWFGDKTKTLNYTPKSGEMVLTVHRWFANKSCPGDWMYARMGDLATKVTQKLSGGTTDTGKTDTPTSDTTTLYRVQTGAFAKKANADAFAAKLKAAGFATYIVQIGGLYKVQVGAFAKKANAESMMAKLKAAGYSGFITTQTSTTTKSEPAKKTAAEIAKEIFYGTCSDSRWSTWGNGATRTSRLKQAGYNPSEVQAEVNKLF
Physico‐chemical
properties
protein length:692 AA
molecular weight:75155,7 Da
isoelectric point:9,26
hydropathy:-0,50
Representative Protein Details
Accession
1dRNc
Protein name
1dRNc
Sequence length
694 AA
Molecular weight
75508,08690 Da
Isoelectric point
9,27553
Sequence
MAFKMRTSKPEAGNKYYITKANGGYSDAIKGSPTDKDCDVLSNCVGYAYGRFNEIGGYGYCKYLRPVNAENFIQYKGIALKTGQTPKLGACMVWQKGATLNGSDGAGHVAIVEKVVSDTEVYTSESGWGSSTPFWNKTRTKGNGNWGQGTAYKFLGFIYNPAVSDEKPADTTPTPSTSGSTDEKTIWDYLLSKIGNEYGVAGLMGNLYAESCLRPNNLQNAYETRLGYTDASYTAAVDNGSYTKFGTDSAGYGLAQWTYHTRKKALLAFAQRKKKSIGDLNMQLEFMYKELSESYKGVLADLKSAKTVLAASNSVLTKYERPANQGAAVQSKRAEFGQKYYEKYAGKTVSSTPQETGKETTNMGYTNSSLVSYTKLSPNHSGQRTHSIDRITPHCVVGQCSVETLGNIFAPTSKQASCNYGIGVDGRVGMYVEEKNRSWCSSSAANDQRAITIECASDATAPYAFKDVVYNKLIELCVDICKRNGKNKLLWFGDKTKTLNYTPKSGEMVLTVHRWFANKSCPGDWMYARMGDLATKVTQKLSGGATDTGKTDTPTSDTTTLYRVQTGAFAKKANADAFAAKLKAAGFATYIVQIGGLYKVQVGAFAKKANAENMMAKLKAAGYSGFITTQTSTTTKSEPAKKTAAEIAKEIFYGTCSDSRWSTWGNGATRTSRLKQAGYNPSEVQAEVNKLFSK
Other Proteins in cluster: phalp2_39893
Total (incl. this protein): 8 Avg length: 707,0 Avg pI: 9,21
Protein ID Length (AA) pI
1dRNc 694 9,27553
5QCjx 694 9,32408
6624T 694 9,28353
67TV 808 8,84753
6m8XD 692 9,25407
6qV0f 690 9,18019
7YXK2 692 9,23170
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_38065
6q8ry
 127 39,1% 547 3.863E-79
2 phalp2_26355
1k2gh
 2 31,0% 538 2.402E-55

Domains

Domains [InterPro]
CHAP
Phage_lys2
Ami2
SPOR
CW_7
Representative sequence (used for alignment): 1dRNc (694 AA)
Member sequence: A0A8S5QR58 (692 AA)
1 694 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510, PF05036, PF05257, PF08230, PF18013

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctE6L85
[NCBI] 		2826202 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015711 [NCBI]
CDS location
range 55893 -> 57971
strand -
CDS
ATGGCTTTTAAGATGCGAACCAGCAAGCCGGAAGCTGGAAACAAATATTACATCACCAAAGCAAGCGGTGGTTATTCCGACGCAATTAAGGGAAGCCCCACAGATAAGGACTGCGATGTTCTTTCCAACTGTGTTGGGTATGCCTATGGACGATTCAATGAAATTGGTGGATATGGGTACTGTAAGTACCTCCGTCCTGTAAACGCCGAAAACTTCATTCAGTACAAAGGTACTGCGCTGAAGACCGGACAGACACCGAAGCTTGGCGCCTGTATGGTCTGGCAGAAAGGCGCTACGCTGAACGGCTCTGACGGAGCGGGTCATGTCGCTATTGTCGAGAAGGTTGTCAGCGATACGGAAGTATATACATCCGAAAGCGGCTGGGGTAGTTCCACCCCGTTTTGGAACAAGACAAGGACAAAAGGAAATGGTAACTGGGGTCAAGGGGCTGCTTACAAGTTCCTTGGCTTTATTTATAATCCGGCAGTCTCTGATGAAAAACCGGCGGGTACTACGCCTACCCCGTCCACCTCTGGCAGCACAGATGAAAAAACGATTTGGGACTATCTGCTCGGCAAGATTGGGAACGAATATGGCGTTGCCGGTCTGATGGGGAATCTCTACGCAGAGTCATGCTTGCGTCCTAACAACCTCCAGAACGCCTATGAAACGCGGCTTGGGTACACGGACGCCTCCTATACCGCCGCTGTGGATAACGGCTCTTACACGAAGTTCGGCACAGACAGTGCAGGCTATGGTCTGGCGCAGTGGACATATCACACCAGAAAGAAAGCGCTACTTGCCTTTGCGCAGCGCAAGAAGAAGTCTATCGGCGACCTGAATATGCAGCTTGAGTTCATGTACAAGGAACTGAGCGAAAGCTATAAAGGTGTCCTTGCTGATTTGAAGTCTGCCAAGACCGTGCTTGCAGCCTCCAACTCTGTCCTTACGAAGTTCGAGCGTCCGGCCAATCAGGGCGCTGCCGTTCAGAGTAAACGGGCAGAGTTCGGTCAGAAGTACTACGAAAAGTATGCAGGCAAAACGGTGTCAAGCACACCGCAAGAAACAGGAAAGGAGACGACGAATATGGGTTATACAAACAGTTCACTGGTGTCCTACACCAAACTCAGCCCTAACCATTCTGGACAGCGCACGCAGGCTATTGACCGCATTACACCGCACTGTGTGGTGGGTCAGTGCAGCGTGGAAACGCTGGGCAATATCTTTGCTCCGACTTCCAAGCAGGCAAGCTGCAACTATGGTATCGGCGTAGACGGGCGTGTTGGTATGTATGTAGAGGAAAAGAACCGTTCTTGGTGTTCTTCTTCTGCCGCCAACGACCAGCGTGCAATCACCATCGAATGTGCATCCGATGCCACAGAACCGTATGCCTTTAAGGATGTTGTTTACAACAAGCTCATTGAGCTTTGCGTAGACATCTGCAAACGCAACGGTAAGAACAAACTGCTGTGGTTTGGGGACAAGACCAAAACTCTCAACTATACGCCGAAGTCTGGCGAAATGGTGCTGACAGTCCATCGTTGGTTCGCCAACAAGTCCTGCCCCGGCGATTGGATGTATGCTCGCATGGGAGACCTTGCCACTAAGGTTACGCAGAAACTTTCGGGCGGTACTACCGACACCGGTAAAACGGACACGCCCACCTCTGATACAACCACGCTGTACAGAGTGCAGACAGGTGCTTTTGCAAAGAAAGCAAATGCCGATGCGTTTGCGGCAAAGTTGAAAGCCGCTGGGTTTGCTACATACATTGTGCAGATTGGCGGGCTATACAAGGTTCAGGTTGGCGCCTTTGCGAAGAAGGCAAATGCGGAAAGCATGATGGCAAAGCTGAAAGCCGCTGGGTATTCCGGATTTATCACTACGCAGACCAGTACGACCACCAAGAGTGAACCGGCAAAGAAAACAGCCGCAGAGATTGCGAAAGAGATTTTCTATGGCACTTGCTCCGATTCCCGCTGGTCTACATGGGGTAACGGTGCCACTCGGACAAGCCGGTTGAAGCAGGCCGGTTACAACCCGTCTGAGGTTCAGGCGGAAGTCAACAAGTTGTTTTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0042834 peptidoglycan binding molecular function None (UniProt)
GO:0046872 metal ion binding molecular function None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (1dRNc) rather than this protein.
PDB ID
1dRNc
Method AlphaFoldv2
Resolution 85.49
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50