Protein

Protein accession
A0A8S5PUH4 [UniProt]
Representative
4xoTh
Source
UniProt (cluster: phalp2_7368)
Protein name
Peptidoglycan hydrolase
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MTEKQIRAQVVATAEAWLGVRAGSAQHKEIIKLYNAQRPLPRGTRMQEGWAWCAAFVSAVSLKLGLRDIMPTEMSCHQMVLLYRKLGRWAENDAYVPSPGDVIFYDWDDGRNYASTDNTGTPDHVGIVTACDGKTISVIEGNVNSKVAMRTLAVNGRYIRGFGIPDFSNKATEEEKPAEPDKVGDLARRLATEINDSGLDAVAVLAKVSALLGAKPTEPAKPAEPEKKAPTAAEIDAMARDVIAGKFGNGATRRALLGNNYDEVQKRVNEILRG
Physico‐chemical
properties
protein length:274 AA
molecular weight:29794,6 Da
isoelectric point:7,67
hydropathy:-0,35
Representative Protein Details
Accession
4xoTh
Protein name
4xoTh
Sequence length
312 AA
Molecular weight
32791,31650 Da
Isoelectric point
9,01424
Sequence
MTEQELRSKVVSIAQGWLGCKESNGTHKPIIDLYNSHKPLARGYPVKYTDAWCSTFASAVAIKAGLTDIIPTECGCGKHVELFKKLGSWQENDAYVPSPGDYIFYDWQDGASYATTDNTGAPDHVGIVEKVSGSSITIIEGNMSNAVGRRTIKVNGRYIRGYGVPKYASKAKDTGTGTGASTGTTAPSTGLSVGDVVNFTGTAHYASSNATAPKSCKPGRAKITATAKGAKHPYHLIAESGGGSSVYGWVDTADIGSTTASAARTYTVRKGDSLWAIAAKLLGNGSRYTEIKSLNGLSGDTIHAGQVLRLPD
Other Proteins in cluster: phalp2_7368
Total (incl. this protein): 314 Avg length: 310,6 Avg pI: 8,95
Protein ID Length (AA) pI
4xoTh 312 9,01424
137SW 286 8,48296
13DnZ 318 8,72291
13tp5 333 9,16484
1HswY 359 9,33929
1jB5W 307 9,06917
1kY3I 263 9,63398
1mdav 325 8,94565
1n9i8 304 9,09734
1ndrH 325 9,02501
1nk23 318 8,56857
1ocfQ 325 9,01785
1oxBE 318 8,90445
23Gzy 361 9,43316
23OKc 285 9,08645
24L8l 263 9,18592
24sIu 361 9,50188
2lDNM 283 8,74870
2lTHy 325 9,02501
2lWzy 333 9,11114
2lXUg 304 8,86996
2m31t 318 8,94152
2rBo 304 9,09734
3B16D 282 9,18508
3B1a8 325 9,01792
3GHh2 316 8,94733
3TOeD 272 8,73213
3kLuM 325 9,02501
3kMWL 318 8,56857
3kSxO 304 9,09734
3kV5q 316 9,03539
3kfwQ 325 9,02501
3lboZ 318 8,71640
3mkdU 318 8,83779
3mr4z 323 9,02501
3o3ev 307 9,04364
3oSNX 306 9,09734
3pHkj 333 9,11849
3pJwL 304 9,09734
3pKMy 304 9,09734
3pSP7 304 9,09734
3qw7J 304 9,09734
3rZfh 316 8,72807
3rbeh 333 9,11114
3rcea 308 9,18109
3sJNu 304 9,09734
3tKRM 282 9,04371
3tSe1 304 9,09734
3tc0E 316 9,07923
3td4J 304 9,10501
3tn8e 325 8,86990
3trb3 325 8,94565
3tsjn 242 8,84933
3uQ3u 312 8,83779
3ucC8 316 8,84669
3ussh 318 8,83766
3v30A 304 8,86352
3vCeg 282 9,28069
3vTbL 325 9,02501
3vZRP 304 8,87003
3vtD1 304 9,09734
3vzOd 304 9,09734
3wbL4 304 9,10514
3wovm 325 9,09709
3x37z 282 8,85359
3xn5c 333 9,04538
3xra1 316 8,94733
3xvvy 304 9,09734
3ywcn 316 8,94739
3yyft 326 8,93907
3zrYA 282 9,02714
45qFS 282 9,07040
4k5zT 439 9,21274
4xCk5 312 9,10695
4y6CB 267 9,09741
4y7Sc 277 9,14879
4y7aT 288 8,90877
4yj2h 338 9,33059
4yntU 284 8,83012
4yusg 263 9,18599
4z3cB 316 8,94739
5KDqw 325 8,94565
5KDuc 318 8,71640
5KQ0g 304 9,16362
5KRgZ 304 9,21667
5KYLW 304 9,09734
5Ka6O 306 9,02520
5LTfh 304 9,09734
5Lk8e 325 9,08948
5M7Pq 304 9,12809
5N8Dt 318 8,72330
5OVf9 325 9,03223
5OdZf 325 8,94565
5OjwU 318 8,37678
5OwcF 304 9,09734
5P36F 282 9,18521
5PWPC 316 8,84669
5QTk6 304 9,09734
5QbnV 325 8,94565
5QphH 325 8,95242
5R7MU 325 8,86990
5R7UB 325 9,01792
5RQIx 318 8,83779
5RWcV 304 9,09734
5S5VZ 304 9,09721
5S9hZ 325 9,03223
5SFRm 304 9,09734
5SJbX 318 8,83779
5SNji 325 8,94565
5SclD 325 8,86345
5Stlw 281 9,02714
5TLYn 304 9,16349
5TjN1 325 9,02501
5UBMs 304 9,02520
5UJmt 325 8,94565
5URx7 282 9,28069
5Un2z 282 8,96299
5UrXt 318 8,83766
5UzsU 325 9,02501
5VLZS 325 9,02501
5VVa5 318 8,71640
5VviE 325 8,94565
5WMVR 304 9,09734
5WNO3 318 8,83779
5Wfrd 304 9,16362
5WspE 325 8,94565
5WvfC 304 9,02520
5X3Zg 318 8,71640
5X7tO 316 8,84669
5XMf8 316 8,84669
5Xyzy 299 9,23369
5YJJA 325 8,94565
5YRLs 325 9,16323
5YRVK 318 8,83064
5YVqJ 318 8,83766
5Yloh 318 9,08103
5Ywx2 315 8,72807
5Z1vW 317 7,63594
5ZE8K 304 9,09734
5ZiWS 304 9,10514
5yAX 333 9,11849
606o5 325 9,02501
609Ov 318 8,56857
60AyW 318 8,71640
60EaK 316 8,84669
60GxX 325 9,08948
60NTh 318 8,83792
60Yuu 316 8,94739
60pfN 325 8,94565
628pE 318 8,83779
62Bs2 318 8,83779
62VEh 326 9,02501
62fsh 318 8,71640
62vcM 325 9,02501
62vfP 318 8,71640
62wqa 304 8,95268
63ieU 304 9,05956
641p5 318 8,56857
655MS 282 9,09728
65GgI 304 9,09734
65PaR 318 8,71640
65VW5 318 8,71640
65tPQ 282 9,13158
66cKB 318 8,83779
66vUA 318 8,83779
67bpx 318 8,94139
67sYy 325 8,86345
680Yq 304 9,03990
68iHk 325 8,94565
68s82 316 8,58224
69Sk8 318 8,71640
69VoH 325 9,16323
69WaN 269 7,61821
6YLCk 325 9,02501
6ZFex 329 8,76843
6ZcPf 304 9,22486
6ZxNc 297 9,03249
6aDdx 304 9,09734
6aDuf 318 8,83760
6aOmP 325 9,02501
6aTCA 318 8,71640
6bY7B 325 8,94565
6bhdQ 304 9,09734
6biqt 242 8,08899
6bwbT 325 9,02501
6c2w6 282 9,02714
6cn2I 304 9,09734
6cuDh 318 8,83766
6d4Ux 325 8,94565
6dCo1 318 8,71640
6dMhP 318 8,83779
6dWhF 325 9,02501
6db7d 318 8,71640
6dbTs 304 9,08974
6erXq 318 8,83766
6f2n6 325 8,94565
6fp8A 318 8,56857
6glxi 325 9,02501
6h0vJ 325 8,86345
6hINi 304 9,21667
6hYui 304 9,09734
6htx6 325 8,94565
6huyL 304 9,16362
6i2uz 304 9,09734
6iC9C 325 8,94565
6iTXZ 318 8,71640
6j3zC 304 9,02520
6jMo0 318 8,83779
6jpBe 325 8,76211
6k7Lq 304 9,02520
6l15T 318 8,56857
6lMzh 294 9,03236
6lTPu 318 8,71640
6lZKk 304 8,95268
6li3D 318 8,71640
6llDT 304 9,03249
6lsM3 325 9,02501
6luzr 314 8,94159
6mGrZ 318 8,83779
6mXRM 325 8,90748
6n7ih 325 8,94565
6nLJl 325 9,02501
6nZ3Z 318 8,71640
6nfRC 325 8,94565
6nlOM 316 8,94739
6oVis 325 9,09702
6orKg 318 8,83779
6otIK 304 9,09734
6p6tG 325 8,94565
6pGVv 304 9,02520
6piVG 325 9,09702
6plxi 318 8,71698
6q7Uh 325 9,02501
6q9Oq 304 8,95268
6qXZy 325 9,15543
6qibc 307 8,87628
6qtoU 243 9,48428
6rgUB 325 8,94565
6ruhy 318 8,71640
6ryST 318 8,71640
6s29q 318 8,72304
6s7Vb 325 9,02501
6s8EL 318 8,83779
6sRqe 318 8,71640
6skaI 304 9,09734
6t8qw 304 9,10501
6t9mM 318 8,56857
6tCwO 316 8,84669
6tN8Z 304 9,03977
6tjZq 304 9,16349
6ttnI 282 9,08819
6u0qF 285 8,97692
6u4Fh 304 9,03249
6uCeV 304 9,09734
6uLOp 282 8,96299
6ubNd 329 8,76843
6ufhl 316 8,72807
6uplR 325 8,94565
6uu3a 282 9,08825
6uzB4 304 9,02520
6v0nu 316 8,58224
6v1KT 325 9,02501
6vPmX 304 9,16349
6vlt1 333 9,11127
6w57X 318 8,71640
6w9kp 316 8,94739
6wbFD 318 8,56857
70Nc3 318 8,83779
7BD4g 297 9,16362
7DNUp 318 9,01663
7MEJC 304 9,09734
7MpOd 304 9,03249
7NqPO 304 9,09734
7OwGC 265 8,34603
7ReNA 312 9,55281
7Vonb 325 8,93907
7YS9S 318 8,94152
7YgUH 316 8,84669
7Yq92 227 8,16790
7ZE0C 316 8,94739
7Zyil 280 9,28275
7tRo2 304 9,03977
7xAbJ 304 9,02520
7xF7K 304 9,10508
7yoxi 282 8,92528
80rjD 304 9,16349
80sNw 316 8,84669
83wcp 304 9,16349
86OHG 321 8,73477
88AkR 325 8,95255
8987J 304 9,09734
89vA4 316 9,03539
8b0GY 304 9,10501
8cDTw 325 9,09709
8eyps 243 8,35931
8fqZf 325 8,94565
8ld7B 318 8,71640
8m0Lu 256 9,02359
8m3mT 325 9,02501
8mgM3 265 8,78989
8qRh3 329 8,76843
8qUkY 304 8,95261
8qlJI 316 8,94739
8rA8V 304 9,09734
8rm25 304 9,09734
CTgQ 325 9,09709
F5uN 304 9,03249
HF2C 325 8,94565
KGPR 316 9,03539
O7X5 225 8,18209
a7yr 284 9,08638
rmal 304 9,09734
rn3N 304 9,09734
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_29393
1dfbb
 105 50,0% 314 5.560E-93
2 phalp2_12538
16lqa
 19 39,6% 461 1.285E-91
3 phalp2_15661
2WFec
 420 62,1% 206 1.949E-86
4 phalp2_21388
3uuxO
 25 45,3% 280 1.006E-74
5 phalp2_23993
40d9r
 21 44,5% 305 4.143E-67
6 phalp2_11181
5Pvnh
 15 37,1% 304 1.578E-64
7 phalp2_13290
3nYWL
 48 33,9% 392 4.220E-59
8 phalp2_27238
3TMvJ
 21 48,7% 197 1.585E-56
9 phalp2_12707
3va5F
 1 35,7% 291 2.325E-54
10 phalp2_21653
2VnNi
 2 40,8% 235 2.199E-51

Domains

Domains [InterPro]
CHAP
Unannotated
LysM
Representative sequence (used for alignment): 4xoTh (312 AA)
Member sequence: A0A8S5PUH4 (274 AA)
1 312 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01476, PF05257

Taxonomy

  Name Taxonomy ID Lineage
Phage Myoviridae sp. ctzS633
[NCBI] 		2825212 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015505 [NCBI]
CDS location
range 7983 -> 8807
strand -
CDS
ATGACAGAGAAACAGATCAGAGCACAGGTAGTTGCCACCGCGGAAGCGTGGCTCGGGGTGCGGGCTGGCTCCGCGCAGCACAAGGAGATCATCAAGCTTTACAACGCGCAGCGCCCTCTTCCGCGCGGGACGCGGATGCAGGAGGGCTGGGCGTGGTGCGCGGCGTTTGTGAGCGCCGTGTCCCTCAAGCTCGGTCTCCGCGACATCATGCCGACGGAGATGAGCTGCCACCAGATGGTGCTGCTCTACAGGAAGCTCGGGCGTTGGGCAGAGAACGACGCCTATGTGCCGTCTCCTGGCGACGTCATCTTCTACGACTGGGACGACGGCAGAAACTACGCATCTACCGACAACACCGGCACGCCGGATCACGTCGGCATCGTCACTGCGTGCGACGGCAAGACGATCTCCGTCATCGAGGGCAACGTCAACAGCAAAGTTGCCATGCGGACGCTCGCCGTCAATGGCCGGTACATCCGCGGCTTCGGCATTCCCGATTTTTCCAACAAGGCCACCGAGGAAGAAAAGCCCGCTGAGCCGGACAAGGTGGGCGATCTCGCCCGGAGGCTCGCGACGGAGATCAACGACAGCGGCCTTGACGCGGTGGCGGTGCTCGCCAAGGTATCCGCCCTGCTCGGCGCAAAGCCCACGGAACCCGCAAAGCCCGCAGAGCCGGAAAAGAAAGCTCCGACGGCGGCGGAGATCGACGCCATGGCGCGGGATGTTATTGCCGGGAAGTTCGGCAACGGCGCTACCCGCCGCGCTCTCCTCGGCAACAATTATGACGAAGTTCAGAAGCGCGTGAACGAGATCCTGAGAGGCTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0016787 hydrolase activity molecular function None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4xoTh) rather than this protein.
PDB ID
4xoTh
Method AlphaFoldv2
Resolution 88.59
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50