Protein

Protein accession
A0A8S5PMI1 [UniProt]
Representative
2Vo7e
Source
UniProt (cluster: phalp2_27134)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MVYMGTLNITKNYLTNNRCYQRSDTCAKIGIQIHTIGTGQGTAASVADYWNQPAVSACVHYVCDADVPGNVMQLLPETYRSWADAGWGNNNLISIEICESDYISYTSGASYTIKDETKFKADILRGYNTAVQLCARICRERGWDPLAKLSNGMYLISSHNEGRLAGLSSAHVDPDHVWSRFGLTMDGFRKAVKAAMESTGGPYYVRKSFTDKGSQIGSYTYLQNAEKACRPGYHVYDVNGKLIYSAPVFQKGLRYRMQADLALRAEPKASAPLVQYDTIPGAKRRYFKRGGSGEALIRKGTVDKCQGEEQVGNRGAYMKLTRGWVLAQYQGKNRVSKV
Physico‐chemical
properties
protein length:338 AA
molecular weight:37526,2 Da
isoelectric point:9,28
hydropathy:-0,44
Representative Protein Details
Accession
2Vo7e
Protein name
2Vo7e
Sequence length
755 AA
Molecular weight
83539,25090 Da
Isoelectric point
9,18747
Sequence
MQLHTIGTAQNTASQLASYWNQGGIEACVHYCVDAEQEGLVYQFLPDNRRSWADGGFGNNNLITVELMESDYMRYTGGANYVITNDAKFRSNITTAYNTAVQFFAQKCKQYGWNPLEKMSNGLYRVSSHDEGRRLGLSTSHVDPTHVWGKLGFTMDQFRKDVAKAMGGEIVEVNSDMYRVRKSWADASSQIGAFTVLDNAKKACVYGYKVFDNNGNVVFENNTKPSGTQWTEFVGLSEKDAAEKILELARQDYEKSGILASVTAAQMILESGYVTTELSKANNCFGMKTVLSGNTWPNSTWDGVSKVNIATKEEYTPGVITTIHADFRKYPRIEDSVADHSAYLLGAKNGSRLRYEGLTGCPDYRSAITLIKNGGYATDSKYIDKICNIIERYNLARYDKKNAATVLPIPKPETGANTQNNAVPAAQPVDKYVVRRTFDETVFQLGAFSVLDNAKALADKNLGYQVFDTTTKAVVYSPSLTAIQKFIAKLMQYDQYMQYDNKNKNQWVYYNGKRSAETFWNARKNNKRWTNCVSGVQWAAVDSGLCGSDGICWYGQKGGNIRWTTKNAEANAKKYFNIYHINGKKTVKECVNDGTIKPGDIITYVSMNHTNVYLGDNRSFDSGHAYCAKSGEGAPFKKWCGGLSHGSQKVGCILRAKNSTTQPSNKPATPEAPKTTPSTPNVKSDVKYRVQCGSYKDVKNAKAMVKKMTAKGISASVTNHGLWIAQAGIFSDKSNADRLAKTISAKGLPVAVIKM
Other Proteins in cluster: phalp2_27134
Total (incl. this protein): 4 Avg length: 653,0 Avg pI: 9,25
Protein ID Length (AA) pI
2Vo7e 755 9,18747
2Vdik 755 9,21474
4THMg 764 9,32666
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_781
23EGH
 9 36,6% 695 1.061E-122
2 phalp2_1523
24Dzx
 9 39,8% 515 1.127E-106
3 phalp2_10091
5D9X
 97 27,7% 509 9.147E-40
4 phalp2_3379
3pnB5
 146 28,7% 529 2.239E-34
5 phalp2_29817
23g92
 1 26,4% 619 6.629E-29

Domains

Domains [InterPro]
Ami2
Unannotated
GLUCO
Unannotated
SPOR
Representative sequence (used for alignment): 2Vo7e (755 AA)
Member sequence: A0A8S5PMI1 (338 AA)
1 755 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510, PF01832, PF05036

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ct8NQ14
[NCBI] 		2825363 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015464 [NCBI]
CDS location
range 14993 -> 16009
strand -
CDS
ATGGTTTACATGGGAACTTTAAACATCACAAAGAATTACCTCACAAATAATCGCTGCTACCAGCGGAGCGACACCTGCGCGAAGATCGGCATCCAGATTCACACAATCGGCACCGGCCAGGGGACGGCCGCAAGTGTGGCAGATTACTGGAATCAGCCCGCGGTATCGGCCTGCGTCCACTACGTCTGCGACGCGGATGTTCCCGGCAATGTGATGCAGCTTCTCCCGGAAACGTACCGCTCCTGGGCGGATGCTGGCTGGGGGAACAATAACCTGATTTCCATTGAGATCTGTGAGTCGGATTATATTTCCTATACCAGCGGGGCCAGCTACACAATCAAGGACGAAACAAAATTCAAGGCTGACATCCTGCGGGGCTATAATACCGCTGTCCAGCTCTGCGCGAGAATCTGTAGGGAACGCGGCTGGGACCCGCTTGCGAAGCTCAGTAACGGGATGTACCTGATATCCTCACACAACGAGGGCCGTCTGGCGGGCTTGTCCTCTGCTCACGTTGATCCGGATCACGTTTGGAGTCGCTTCGGTCTGACCATGGACGGTTTCCGGAAAGCCGTGAAAGCAGCTATGGAATCAACTGGCGGCCCGTATTACGTCCGGAAGTCCTTCACAGACAAGGGAAGTCAGATCGGTAGCTACACTTATCTCCAGAACGCTGAGAAGGCCTGCCGGCCAGGCTACCACGTCTACGACGTCAATGGTAAGCTGATCTACAGCGCACCAGTTTTCCAGAAAGGCCTCCGCTACCGCATGCAGGCAGACCTTGCTTTAAGGGCGGAACCGAAAGCCTCCGCACCGCTGGTTCAGTACGACACCATCCCGGGGGCGAAGAGACGTTACTTCAAGCGTGGCGGCTCCGGTGAGGCACTGATCCGGAAAGGCACGGTGGATAAGTGCCAAGGCGAGGAGCAGGTCGGCAACCGGGGTGCTTATATGAAGCTCACCCGCGGCTGGGTCCTGGCTCAGTATCAGGGTAAAAACAGGGTTTCAAAAGTATGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (2Vo7e) rather than this protein.
PDB ID
2Vo7e
Method AlphaFoldv2
Resolution 85.53
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50