Protein

Protein accession
A0A8S5PGE2 [UniProt]
Representative
4jM8q
Source
UniProt (cluster: phalp2_34904)
Protein name
PGRP protein
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MTVRQQLAVQNDCYRRNQGEMGKNPGERDSRYARYYQGPRGVMIHSTGAENPNLRRYVQPDDGTLGVNPNGNDWNRPGLDVAVHAFIGLTRSGEVAAYQILPWEYRAWHCGGSGNDTHLSLEICEDNLQDRGYFDRVYQMAMELTAELCRRFRLDPLAPGVVVDHAEGAALGIASNHADVDHWWSRFGTSMDDFRAGVAQRLQKEEEPAMTREEVAQMISKALEEDRKSRIFPKLANVPGWAGATVQKLMERDALQGDGQGLNLSYDFLRTMVALDRLGALDRKE
Physico‐chemical
properties
protein length:285 AA
molecular weight:32099,6 Da
isoelectric point:5,58
hydropathy:-0,64
Representative Protein Details
Accession
4jM8q
Protein name
4jM8q
Sequence length
263 AA
Molecular weight
28714,28680 Da
Isoelectric point
7,77247
Sequence
VPKGIMVHSTGSENPWIKRYVGPDDGLLGVNSNGNHWNCSGLSVCVHAFIGKLKDGSIATYQTLPWTYRGWHAGGSANNTHIGFEICEDGLSDADYFAKVYNEAIELSTYLCYTYSINPLTGIICHSEGYTKGIASGHADVMHWFPKHGKSMDTFRAEVNTALTKLKAAEATKVEALRIVKLVASSPADWSNALSGSLEGIWAYFPALIVKTYNQRGKTTLGYVEVLKQVTSSPVEWQTAIAAQKTGILQYTGALLEKIYKLS
Other Proteins in cluster: phalp2_34904
Total (incl. this protein): 3 Avg length: 277,7 Avg pI: 6,31
Protein ID Length (AA) pI
4jM8q 263 7,77247
A0A8S5M1D4 285 5,58497
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_35488
tqvH
 739 68,6% 182 9.220E-78
2 phalp2_36672
45lpM
 229 56,2% 192 1.035E-66
3 phalp2_8073
62PL1
 35 51,3% 185 2.114E-58
4 phalp2_23011
3Pylt
 316 41,1% 180 1.754E-35
5 phalp2_39586
6nEZG
 27 35,6% 216 2.511E-33
6 phalp2_17257
3WAN9
 1 42,7% 166 2.697E-29
7 phalp2_24341
3TP9g
 1 31,3% 220 2.761E-23
8 phalp2_3939
7bfSL
 153 31,5% 165 5.841E-10
9 phalp2_27786
7skBJ
 83 29,0% 165 3.500E-08

Domains

Domains [InterPro]
Ami2
Disordered region
Representative sequence (used for alignment): 4jM8q (263 AA)
Member sequence: A0A8S5PGE2 (285 AA)
1 263 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Myoviridae sp. ctdSc46
[NCBI] 		2825141 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015429 [NCBI]
CDS location
range 8602 -> 9459
strand +
CDS
ATGACGGTGCGGCAGCAGCTGGCAGTCCAAAATGACTGCTACCGCCGGAATCAGGGGGAAATGGGAAAGAACCCGGGGGAGCGGGACAGCCGCTATGCCCGATACTATCAAGGCCCCCGAGGGGTGATGATCCATTCCACGGGGGCCGAGAACCCAAACCTGCGGCGCTATGTGCAGCCGGATGATGGCACATTGGGGGTCAATCCCAATGGCAACGATTGGAACCGGCCGGGGCTGGATGTGGCAGTCCACGCCTTCATCGGACTGACCCGGTCGGGAGAGGTGGCGGCCTATCAGATCCTCCCGTGGGAGTACCGGGCCTGGCACTGTGGCGGCAGTGGAAACGACACCCATCTTTCCCTTGAGATTTGTGAGGACAATTTGCAGGATCGGGGGTATTTTGACCGGGTCTACCAGATGGCTATGGAGCTGACGGCAGAGCTGTGCAGGAGGTTCCGGCTGGATCCACTGGCTCCGGGAGTGGTGGTGGACCACGCCGAGGGGGCGGCGCTGGGCATTGCCAGCAACCACGCCGATGTGGACCACTGGTGGAGCCGCTTTGGGACTTCCATGGATGATTTTCGCGCCGGTGTGGCGCAACGGTTGCAGAAGGAGGAGGAACCTGCCATGACCCGAGAGGAAGTGGCACAGATGATAAGCAAGGCCCTGGAGGAGGATCGGAAATCCCGGATTTTCCCCAAGCTGGCAAATGTGCCGGGCTGGGCCGGGGCAACGGTACAAAAGCTGATGGAGCGGGACGCTTTGCAGGGGGATGGACAGGGACTCAACCTGAGCTATGACTTCCTGCGGACCATGGTGGCCCTGGACCGGTTGGGGGCGCTGGATCGGAAGGAGTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4jM8q) rather than this protein.
PDB ID
4jM8q
Method AlphaFoldv2
Resolution 76.02
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50