Protein

Protein accession
A0A8S5P5E1 [UniProt]
Representative
6k3vw
Source
UniProt (cluster: phalp2_4916)
Protein name
Transcriptional regulator
Lysin probability
100%
PhaLP type
endolysin
Probability: 96% (predicted by ML model)
Protein sequence
MMLYTEPWCAATVSALGERLNLTEYIYPECSCNRMIALYQKNGRWEERDDYKPQIGDLCFYDWQDNRVGECTGEADHVGMVCDVSGNTFKVLEGNYSNEVKSRAMQIDGKYIRGFGLPNYAKAAIGYKVPVDKTNIRTMAGQVPYLNIDNNNEAVKMAKILFNSLGFNAGTDTIFDE
Physico‐chemical
properties
protein length:177 AA
molecular weight:20004,4 Da
isoelectric point:4,90
hydropathy:-0,42
Representative Protein Details
Accession
6k3vw
Protein name
6k3vw
Sequence length
470 AA
Molecular weight
51418,72910 Da
Isoelectric point
5,89332
Sequence
MRFGIDISDAQGVFDWGKADGVTFAVLKGGGGNNGFYTNKQFQRNYEECVKRGIDVGCYWFSKALTVEQAEQEAAYFFDSCLTGKKFTLPVYMDVEHKDMLALGKDALTAIVLAFCEALEQRGAWVGIYSSRAMFEGYMHDEQLFKYAHWVAEWGETCRYGRDFGLWQFGGEVNKLRGTKVAGVVCDQDYMLTDYPALLGMSGRNDFREVGNMTEQQLRQKAADTILGWVGLNEADGSHKKIIDIYNSHKPLARGYALKYTDAWCAGTVSAVAIVCGITDIMPTEVGVGKMIDLYKALGRWMERDDYTPQIGDVVVYAWSDNGAGECTTGADHVGIVTKVSGTSFWVTEGNYRDSVKTRSMQVNGRYIRGFGLPDYAKKATGVASTMPTTMVTEKTVTVKLRQLKKGSVGNDVKALQTLLIVGGYSCGSAGADGDFGSGTDIAVKEYQRNHGLTADGVVGAVTWGKLLGA
Other Proteins in cluster: phalp2_4916
Total (incl. this protein): 208 Avg length: 456,1 Avg pI: 6,92
Protein ID Length (AA) pI
6k3vw 470 5,89332
13Fnf 490 8,70924
13aSe 492 8,79363
14LYf 492 8,90123
14LbO 492 7,47310
15LR5 487 6,94990
195Tk 596 6,28164
19bZ7 518 4,44222
19gQh 478 4,98935
19msH 496 6,76739
1HpEy 488 7,48674
1cMaG 522 6,89147
1cNg6 502 8,68952
1ctpJ 520 8,52725
1cuI8 317 8,87467
1culo 285 8,17680
1cvoi 311 8,23811
1dQZB 471 5,22137
1ekiU 530 5,10314
1jTEr 516 8,97208
1k2uV 445 8,96873
1lAxq 429 9,81559
1nbLV 344 5,00572
1zIE9 484 5,15691
1zJWq 490 8,37233
21CM1 511 9,32234
21DsH 488 8,43184
21IUi 549 8,38768
21JS5 327 8,20768
21jSy 471 8,80782
21lIn 559 8,63923
21lVY 517 6,08782
21odu 483 8,78067
21yN1 489 7,09802
21zqB 514 8,50224
234Am 484 5,31362
236KY 521 8,49901
236qw 522 8,36086
2371f 502 8,53544
238zM 369 8,44492
239oN 629 9,25284
23CaE 479 5,16907
23CpG 484 5,24672
23DO8 564 7,53210
23Kud 522 8,10169
23OBj 541 8,63066
23ODt 519 6,45210
23dAp 560 5,77543
23hHC 517 9,08580
23qj9 490 9,27134
23rq2 515 8,40676
23yXw 503 8,66495
23zzJ 509 8,34300
24CKX 478 8,98349
24Jv0 515 5,82397
24K0u 526 8,50017
24LNL 513 5,72536
24n8j 565 5,65920
24oGM 471 8,05792
24oZ8 523 7,07494
24smw 520 8,65960
290tN 492 8,86023
29r6h 492 7,48515
2NRvq 520 8,76591
2Vb44 439 8,98833
2VbDO 497 6,88845
2VbpN 492 7,48509
2Vdbh 531 6,21122
2Vdoh 491 8,70512
2VisJ 428 5,85484
2Vj6C 504 9,16471
2VkZg 514 8,74954
2VlcY 410 8,53215
2VmKM 520 4,58602
2VmYQ 491 8,49308
2lUi7 344 5,14782
2m0iW 344 5,14782
36myw 492 7,48634
38OEK 480 5,37404
3TFW0 522 8,27357
3TGXO 545 6,16472
3TKaL 451 8,41694
3TOFG 525 7,95006
3TOTC 441 5,61486
3TPC9 497 7,02788
3VE9f 586 6,05565
3VGLK 537 4,93189
3VGM0 543 4,79456
3VMHj 522 8,34364
3WEDU 567 8,71485
3WH8D 398 5,15481
3WI8m 522 7,86464
3WIsm 538 4,67622
3WN8K 464 8,72414
3WyE8 454 6,79046
3WyYz 383 9,14363
3ZAJk 461 5,05915
3ZPMf 489 5,05301
3d6JY 487 6,94660
3d8c5 490 8,50739
3dOkW 516 4,35088
3dQWQ 559 5,18567
3e2LX 471 4,50412
3iZ33 521 4,37663
3igbI 520 8,65432
3l2mP 344 5,02772
3qXvi 344 5,07603
3r3rQ 344 5,07603
3rfJH 344 5,01362
3sCej 344 5,14782
3sjIr 344 5,14782
3ubv3 492 7,93472
3vw0R 344 5,16140
40CvZ 750 4,63035
40DUX 346 4,93251
41cvY 464 8,68732
41dJe 398 5,24916
41eNg 483 5,47333
41haY 479 8,19330
41i3c 470 8,67765
41jBS 503 6,77142
41k2l 538 4,85635
4CBIn 497 9,03107
4FZNq 490 7,93485
4JXTJ 544 5,38285
4JYu8 538 4,83674
4L0OY 472 7,42928
4L5CP 477 8,66315
4LbKr 462 8,96647
4j5ud 492 6,27812
4konn 524 4,30711
4xEsp 527 5,54705
5HJEY 387 4,81059
5HVrV 487 8,45865
5KxE0 344 5,14782
5LN4Z 478 7,16412
5LgtS 320 8,33449
5NJnD 346 6,18626
5NK6L 492 8,63375
5OMpm 478 7,16373
5ORXQ 345 5,08370
5Qu87 344 5,14782
5ShI5 466 5,56592
5TJ5I 471 5,37364
5TdVI 344 5,02010
5UeIa 435 5,65630
5X4GI 344 5,06801
5XGVl 344 5,14782
5YfwT 344 5,16140
5YvmD 320 8,89556
5ZYHT 344 5,14782
5ZrfF 344 5,22984
5Zvxi 344 5,07603
5Zx1J 441 5,03948
5iZ4P 319 9,20887
5iZs7 322 8,51674
5oGsy 498 8,51558
5tUZS 324 8,97505
5tXkM 322 9,03868
5txaE 419 8,78248
61GKr 344 5,14782
63fZT 344 5,14782
65H4m 536 8,56451
65ZjA 572 9,01573
698Nb 344 5,23563
6AHOc 441 9,40060
6AHQx 322 9,46520
6MNra 420 8,45085
6UHOV 361 9,15285
6UI1n 325 9,10650
6aQ8p 344 5,15384
6ajdG 344 5,14782
6bjHy 525 5,82068
6dmAV 572 9,26341
6eE4s 344 5,06961
6gwmN 522 6,90499
6hbiP 344 5,14782
6jNNx 344 4,94951
6kx04 344 5,32316
6oLVN 466 5,37637
6qglk 522 8,19904
6ue6B 348 5,07603
6v6Yb 421 5,07160
6wMg 502 8,20252
6wqYS 347 5,08990
73Ogc 492 8,63375
7ATL9 491 7,48515
7BTC9 496 8,58372
7C1kZ 439 9,50652
7DOlT 487 5,90883
7MpSV 344 5,06819
7q0Fl 568 8,84804
7q0QM 543 4,94359
7q1Gx 507 4,61484
7vNnf 495 7,93182
8b0NG 344 5,07603
8eOxx 466 5,37637
8fjE8 403 8,14843
8fwtP 520 8,76295
8jQkK 447 5,20005
8lmnF 525 6,30085
8qOSU 440 5,11059
9YuV 492 5,43036
BR10 344 5,02010
K0NX 323 8,92463
n2bH 527 5,25007
A0A8S5PJQ8 177 4,89528
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_2377
7JCYq
 91 37,4% 475 1.511E-162
2 phalp2_1509
21BcC
 2 29,9% 497 1.897E-115
3 phalp2_34377
4dm6y
 15 37,8% 552 3.734E-110
4 phalp2_38736
13rhz
 58 30,3% 461 3.602E-107
5 phalp2_39103
2m4j4
 107 32,9% 316 2.734E-102
6 phalp2_10962
4Lap7
 1 29,7% 386 4.873E-99
7 phalp2_8913
3e2kK
 9 26,8% 496 3.163E-83
8 phalp2_23963
24Ldx
 5 26,2% 484 3.326E-81
9 phalp2_22079
5L6nf
 5 25,4% 444 5.350E-73
10 phalp2_2537
6a7No
 192 26,5% 471 6.345E-72

Domains

Domains [InterPro]
GH25
CHAP
PG_1
Representative sequence (used for alignment): 6k3vw (470 AA)
Member sequence: A0A8S5P5E1 (177 AA)
1 470 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF01471, PF05257

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctJcm18
[NCBI] 		2825433 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015323 [NCBI]
CDS location
range 43501 -> 44034
strand +
CDS
ATGATGTTGTATACAGAACCTTGGTGTGCAGCTACCGTTTCCGCTCTTGGGGAGAGATTAAATTTGACGGAATATATCTATCCTGAATGTAGTTGTAATAGAATGATAGCTCTCTACCAAAAGAATGGAAGATGGGAAGAAAGAGACGATTACAAGCCTCAAATTGGAGATTTGTGTTTTTACGATTGGCAAGACAATAGAGTTGGAGAATGTACTGGAGAAGCTGACCATGTTGGCATGGTTTGTGACGTAAGTGGAAATACTTTTAAAGTTTTAGAAGGAAATTATTCCAATGAAGTCAAGAGTCGCGCAATGCAAATTGATGGTAAATATATTAGAGGTTTTGGTTTACCAAATTATGCTAAAGCTGCAATCGGTTATAAAGTTCCAGTTGATAAAACTAATATTAGAACTATGGCTGGTCAAGTACCCTATTTAAACATAGACAATAATAACGAAGCTGTTAAGATGGCTAAGATTCTTTTTAATAGTCTGGGGTTTAATGCTGGGACAGACACAATTTTCGATGAATAG

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (6k3vw) rather than this protein.
PDB ID
6k3vw
Method AlphaFoldv2
Resolution 90.53
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50