Protein

Protein accession
A0A8S5MTN9 [UniProt]
Representative
6gC98
Source
UniProt (cluster: phalp2_16417)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 95% (predicted by ML model)
Protein sequence
MSKLQEFLNLGDYYASNGGYLEKKSNAYLDDFKKNAGYNNYTKFARDVNSWGQPGCQGQPWCAEYQFWKLVKVIGITNAIKIMGGGFYNCVSITNWAKKKGTWHNTPKVGALVIFRNGSHVGSVQSFNSSRIYTNEGNTSSVAGVVANGGAVRNKSYSINDSAIDGYVWIDWESYEDTATWKKTGTRVSTVNDLYVRETPNGYIMGSINKNTVVEIDGKTSGKWTHVKVSGIGIGWIWTGYLAREGGSASATITEKQDRTQVLFKGNVTATVLNVRTWAGTEYPNIKKYPKLNQGNEVEVMNFTQKDKNGSKWYYVRIAGKYYGFVSAKYIKKQ
Physico‐chemical
properties
protein length:334 AA
molecular weight:37316,5 Da
isoelectric point:9,53
hydropathy:-0,53
Representative Protein Details
Accession
6gC98
Protein name
6gC98
Sequence length
563 AA
Molecular weight
62884,49500 Da
Isoelectric point
9,43142
Sequence
MTYIGICAGARPEKGRQMEIKGIDVSSWQGKPDWAKVSKSGVKFAILRIHQKSGIDESFEHNYKGCKSNGILIGGYKYSYALTPAQAIDEAEDVLSVLCGRGLDFPVFYDLEWKQQRSLGKQAIENIAVAFLTRIKKAGYKAGIYCNLDWHNNVLSDALKQYDCWIARYPANDNGSAQERLRPNVGVGWQYSSKGKVPGINGNIDMDVFYTDYRTEQKGEVTVTKTKLQKFTELGDYYANNGGNKPYLEKRTNAYLDDFQKNAGYNNYTKFARDVDNWGQPGCQGQPWCAEFQFWKLVKILGITKALQIMGGGFYNCRSITQWAKKNGTWHSTPKDGALVIFRDGSHIGSVRTFSKTYVYTNEGNTSSATGVIANGGSCRNKQYLLSNPVIDGYVWIDWDRKTQSTDTWKATGTATSTVDDLYIRETPNGYVLGQINKGNRVEINGEKSGMWTKVKVVGIGIGWAATKYLQVDGAENKPTTITNKQNKTQRLFVGKVSAASTVVRTWAGGNYPSIKKWPKLVRGNLVDVMNFTQKATNGVSWHYVRIAGKYYGFVAAKDICKV
Other Proteins in cluster: phalp2_16417
Total (incl. this protein): 231 Avg length: 493,7 Avg pI: 9,28
Protein ID Length (AA) pI
6gC98 563 9,43142
21EfG 495 9,45675
24nKV 495 9,52412
2lRKG 471 9,28069
3B3kZ 548 9,36663
3KMbR 548 9,26625
3kkMh 471 9,30687
3l36n 471 9,33259
3lJZf 485 9,33040
3lUZz 473 9,37198
3lVw7 471 9,16297
3m4SB 495 8,83244
3m9zc 495 8,89111
3mdnp 473 9,29977
3mlJk 473 9,39938
3morU 471 9,20829
3mqd7 471 9,26477
3mxHD 473 9,40602
3myfu 473 9,37198
3qZlU 473 9,33123
3qgEJ 471 9,30699
3rPE8 586 9,23950
3sOd5 471 9,25226
3sOqe 473 9,39957
3sTCE 473 9,39925
3stTl 471 9,20281
3sty3 479 9,41840
3t0I7 586 9,28881
3t8El 473 9,37888
3tkdl 507 9,26399
3ttKu 581 9,20501
3uENe 473 9,29365
3uPOJ 482 9,23318
3wh8A 474 8,85559
3xt3e 471 9,19089
5KD00 546 9,50034
5KR9R 474 9,24601
5KV0y 470 9,15466
5Kfs9 546 9,51207
5Khx1 480 9,15627
5L6vx 471 9,25226
5LJJ0 471 9,29359
5Lkez 484 9,21938
5LlZp 474 9,32530
5LxiS 471 9,32730
5MFNf 471 9,18508
5MV4v 488 9,19572
5Mg9V 546 9,35986
5MuKc 473 9,33659
5N2Z9 473 9,34774
5N9b9 575 9,29417
5NFDp 479 9,36927
5NtvS 478 9,25052
5O0UG 490 9,23647
5OBOA 479 9,19289
5PckN 471 9,24594
5Pote 473 9,39938
5QEEs 546 9,44657
5QSGb 478 9,29397
5QUyQ 471 9,19089
5QXZp 482 9,19611
5Qbms 542 9,32079
5Qgiy 471 9,26084
5QpSV 471 9,25226
5R1Rf 481 9,09122
5R9Cm 471 9,24601
5RAOW 471 9,14015
5RBjk 546 9,59530
5RIp6 470 8,93288
5RKsH 474 9,23556
5RqRp 478 9,39300
5Rx97 473 9,43193
5SW5N 482 9,28005
5ScPH 482 9,22480
5U6fq 546 9,53102
5V33T 485 9,26167
5VFkC 484 9,38616
5VSa8 474 9,21487
5VikZ 473 9,36579
5Vt21 488 8,73361
5WQMI 474 9,06775
5WYCV 553 9,51839
5X4Nx 557 9,51271
5XH9H 546 9,41904
5Xs8h 474 9,25465
5Y5pF 474 9,28063
5YdKe 471 9,29977
5YzXY 474 9,20275
5Z2H3 473 9,23157
5Z2X8 575 9,18818
5Z5YR 473 9,31828
5ZF3T 473 9,35412
5ZZPe 474 9,22312
5ZdmB 548 9,22544
5Zrof 473 9,31209
60DUp 488 8,79724
60KSq 471 9,33259
60Rvy 471 9,24601
60omf 546 9,51897
60u6a 471 9,28701
61gQl 479 9,36089
61iCb 536 9,22976
61iJS 575 9,26129
62IZw 474 9,11423
62J4M 559 9,47680
62i0h 488 8,58385
62rYF 546 9,42826
636rZ 544 9,23195
63BiX 471 9,26084
63Hde 471 9,18747
63mwA 482 9,23917
64HxF 473 9,39880
64Lef 546 9,55513
64iJ1 484 9,30590
64jj5 473 9,40602
64poS 473 9,38623
653qN 575 9,23962
655uF 473 9,40602
65tOZ 492 9,24923
664Gu 473 9,40602
66muJ 473 9,36547
67XaU 473 9,33659
67d7s 478 9,36953
690Yw 546 9,53721
690f8 473 9,34806
69BV3 484 9,31183
69KQ1 471 9,29410
69N8b 484 9,31183
69O4f 559 9,42639
69Wl6 506 9,14460
69xjR 473 9,25594
6YIId 482 9,31918
6YuJa 478 9,33542
6Zxlh 473 9,37198
6aAMk 548 9,47532
6aY8B 473 9,37198
6azTS 482 9,19611
6bHJK 546 9,52496
6bM6n 545 9,26038
6byNR 485 9,14453
6c8Kw 581 9,29417
6ckeW 488 8,79724
6cxsh 473 9,45656
6d4Ni 478 9,39570
6dHZu 547 9,22016
6dI08 473 9,33671
6dR1n 548 9,31634
6dsAk 471 9,28069
6eT1x 475 8,75315
6eV0z 482 9,15040
6ef6j 548 9,27734
6efk1 575 9,27283
6ej1h 548 9,40454
6fPja 471 9,32730
6g6Iv 476 9,23647
6gdrK 471 9,25226
6gss7 473 9,36547
6h1DF 484 9,29990
6hF0D 546 9,46675
6hsRY 473 9,43181
6jAWY 581 9,24465
6jZW8 484 9,29990
6k4io 482 9,41459
6kLlw 479 9,23253
6kni8 478 9,15775
6lEiX 474 8,95945
6lhpW 485 9,29352
6lyp7 473 9,30596
6mH2i 471 9,26528
6mYLb 471 9,20894
6mkZ4 471 9,23376
6mlPQ 474 8,73348
6n03b 548 9,47532
6nUcQ 544 9,45089
6nvTJ 548 9,48847
6o8bn 469 9,19224
6oEwg 546 9,56777
6okde 480 9,10218
6p43v 473 9,36914
6pD1J 471 9,16233
6pHVj 471 9,31950
6pWKP 474 9,20268
6phen 473 9,31202
6qFF0 471 9,20894
6rMNw 484 9,35676
6rOEb 473 9,37984
6rbrd 484 9,38616
6rsP8 491 9,28159
6sLlb 485 9,23279
6sScu 471 9,28707
6sUDU 478 9,35934
6sj5u 477 9,35657
6toeb 473 9,35412
6tzP4 549 9,18283
6u7bn 548 9,40234
6uJMC 471 9,33942
6uL8O 471 9,25864
6uSPu 473 9,31209
6ubKG 484 9,35277
6v1vx 581 9,29417
6v9kA 484 9,19224
6vHv6 546 9,50021
6vU5z 648 9,27502
6vrJc 484 9,38616
6w80D 477 9,19656
6wcj5 474 9,28063
6wnwB 546 9,51852
7ZDRO 471 9,24543
7t7oV 473 9,35412
7uRHF 474 8,76475
7uota 471 9,29352
7wHRl 471 9,28701
83VeN 471 9,24543
8f5BK 471 9,24549
8iK6d 474 9,40202
8l51v 488 8,66618
8lxXQ 546 9,48080
8m5v2 471 9,11933
8n6jH 473 8,52280
8nXLq 473 9,35412
8on5v 471 9,27908
8papp 473 9,15279
8piu2 471 9,32582
8pyEs 471 9,25175
8s5km 471 9,15053
8sGSW 471 9,28578
CZJn 482 9,20823
DOZi 473 9,30616
F6hA 482 9,27386
A0A8S5M4E6 547 9,32601
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_30592
67VKs
 21 74,2% 342 1.120E-191
2 phalp2_34762
3ij83
 364 38,4% 591 1.831E-144
3 phalp2_15741
3tdUS
 229 41,1% 484 3.312E-125
4 phalp2_38736
13rhz
 58 36,8% 437 3.714E-79
5 phalp2_2377
7JCYq
 91 30,2% 581 5.871E-74
6 phalp2_1134
5riG
 24 26,9% 608 9.527E-64
7 phalp2_4916
6k3vw
 208 33,1% 431 1.084E-57
8 phalp2_34377
4dm6y
 15 34,8% 405 2.684E-57
9 phalp2_38640
41jQJ
 13 32,9% 391 4.910E-57
10 phalp2_4009
11iJK
 7 28,7% 425 1.261E-42

Domains

Domains [InterPro]
GH25
Unannotated
SH3_3
Unannotated
Representative sequence (used for alignment): 6gC98 (563 AA)
Member sequence: A0A8S5MTN9 (334 AA)
1 563 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF08239

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ct0Xn2
[NCBI] 		2826267 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK014984 [NCBI]
CDS location
range 47507 -> 48511
strand -
CDS
ATGAGCAAATTACAGGAATTTTTAAACCTTGGTGATTATTACGCATCCAACGGCGGGTATCTTGAAAAGAAAAGTAATGCCTATCTGGATGATTTCAAAAAGAATGCCGGATATAACAATTATACTAAATTTGCCCGTGATGTAAACTCATGGGGACAACCAGGATGCCAGGGGCAGCCATGGTGTGCGGAATACCAGTTTTGGAAGCTGGTAAAAGTAATTGGAATCACAAATGCCATCAAAATCATGGGTGGTGGTTTTTACAATTGCGTATCCATCACTAACTGGGCTAAGAAAAAAGGTACTTGGCATAATACTCCAAAGGTAGGTGCGCTTGTAATCTTCCGCAATGGTTCCCACGTTGGAAGTGTGCAGAGTTTTAATAGTTCGAGAATCTATACAAACGAAGGAAATACTTCTAGTGTAGCTGGTGTGGTGGCGAATGGTGGAGCAGTCCGAAATAAATCCTACTCCATCAACGATTCAGCAATAGACGGATATGTTTGGATTGACTGGGAATCCTACGAAGATACAGCCACATGGAAAAAGACTGGAACCAGAGTGTCAACCGTGAATGACTTGTATGTCCGTGAAACACCAAATGGTTATATCATGGGATCAATCAACAAAAATACTGTTGTTGAAATTGATGGAAAGACAAGCGGAAAGTGGACGCATGTTAAAGTTTCCGGTATCGGTATTGGATGGATCTGGACCGGATACCTGGCAAGGGAGGGTGGCTCCGCATCTGCTACTATTACAGAAAAACAGGATAGGACACAGGTGCTTTTCAAGGGGAATGTAACCGCCACTGTGCTTAATGTGCGTACCTGGGCTGGAACTGAGTACCCGAACATTAAAAAATACCCGAAGCTCAACCAGGGAAATGAAGTTGAAGTAATGAATTTTACCCAGAAAGATAAAAACGGTAGTAAGTGGTATTATGTCCGTATTGCTGGAAAATATTATGGCTTTGTATCTGCAAAATACATTAAGAAACAGTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0003824 catalytic activity molecular function None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00001561

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (6gC98) rather than this protein.
PDB ID
6gC98
Method AlphaFoldv2
Resolution 87.17
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50