Protein

Protein accession
A0A8S5LX53 [UniProt]
Representative
nhGL
Source
UniProt (cluster: phalp2_24957)
Protein name
Endodeoxyribonuclease I
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MNIVEKTFETIGVLQTRPKTTLIVLHHAYASNCTVEDIDRWHKGRGWCKIGYHFFIRKDGTIYRGREENAVGAHAYGYNSISIGICAEGNYDVEQMPEAQKNAIIELVTYLKNKYGITEVKKHKDLNNTRCPGANYPFDEIVAKANGNVEFKTINSIEAKSSESRSGNVAADNLVKELQHELNVQKNAGLVEDGIFGPKTANAMFNVRIGARGNITKIIQKALIKKGYSIYGGIDGIFGSDTDRRVRDFQRNNGLVSDGIVGIKTIEKLLK
Physico‐chemical
properties
protein length:271 AA
molecular weight:30154,0 Da
isoelectric point:9,09
hydropathy:-0,42
Representative Protein Details
Accession
nhGL
Protein name
nhGL
Sequence length
270 AA
Molecular weight
30855,96270 Da
Isoelectric point
8,12207
Sequence
MQIIEKVYKLIGTLKKRVKTKRIILHHAAAKVCTPEQVDEWHKARGWTCIGYHFFVRKDGTIYRGRPEWSIGAHASNNNSDSIGICAEGNFEIEIMPEAQKRALKELVSYLKKKYNISIVQRHKDVGQTDCPGKNYPFEEIAKGIDDLKYEVHIQNIGWQECKENGELAGTKRESLRIEAIKIYADIPIRYRVHMQDKGWSEWVSNGCMAGTINESRRIEAIEIESSSRAIKATAHIQDEGDVYYEIATHLIIGTEGRALRLEALALEFV
Other Proteins in cluster: phalp2_24957
Total (incl. this protein): 2 Avg length: 270,5 Avg pI: 8,60
Protein ID Length (AA) pI
nhGL 270 8,12207
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_397
7q1nV
 19 41,4% 181 1.833E-36
2 phalp2_35095
5hWkP
 18 27,3% 304 4.913E-20
3 phalp2_26971
4H6aS
 2 31,8% 201 1.220E-19

Domains

Domains [InterPro]
Ami2
ChW
Representative sequence (used for alignment): nhGL (270 AA)
Member sequence: A0A8S5LX53 (271 AA)
1 270 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510, PF07538

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctRiO19
[NCBI] 		2826337 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK014760 [NCBI]
CDS location
range 2040 -> 2855
strand -
CDS
ATGAATATTGTAGAAAAAACATTTGAAACGATTGGAGTGTTACAAACTAGACCAAAAACTACTTTAATTGTATTGCATCATGCTTATGCATCTAATTGTACTGTTGAAGATATAGATAGATGGCATAAAGGAAGAGGATGGTGCAAGATAGGCTATCACTTCTTCATAAGAAAAGATGGTACTATTTATCGTGGAAGAGAAGAGAACGCTGTTGGTGCTCATGCTTATGGATATAATTCAATTTCAATTGGTATTTGTGCAGAAGGAAACTATGATGTAGAACAAATGCCAGAAGCACAAAAAAACGCAATAATTGAATTAGTAACTTACTTAAAAAATAAGTATGGTATTACTGAAGTCAAAAAACATAAAGATTTAAACAACACAAGGTGTCCAGGAGCAAATTATCCATTTGATGAAATTGTAGCTAAAGCAAATGGCAATGTTGAATTTAAAACAATAAATTCTATTGAAGCAAAAAGTAGCGAATCAAGAAGCGGAAATGTTGCTGCAGACAATTTAGTAAAAGAGTTGCAACACGAATTGAATGTACAAAAAAATGCAGGATTAGTTGAAGATGGAATTTTTGGTCCGAAAACTGCTAACGCAATGTTTAATGTGCGAATTGGAGCAAGAGGAAATATTACTAAAATAATTCAAAAGGCATTAATTAAAAAAGGTTATAGTATTTATGGTGGCATTGACGGAATTTTCGGAAGTGATACAGATAGACGAGTTCGTGATTTCCAAAGAAATAACGGATTAGTTTCAGATGGAATTGTCGGAATAAAAACAATTGAAAAATTACTAAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008270 zinc ion binding molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (nhGL) rather than this protein.
PDB ID
nhGL
Method AlphaFoldv2
Resolution 95.62
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50