Protein

Protein accession
A0A8S5LSC7 [UniProt]
Representative
2fXJB
Source
UniProt (cluster: phalp2_25374)
Protein name
Peptidoglycan hydrolase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MNLVQHFLTNNPCYKAGRKITVKGLMLHSVGCPQPRASAFINSWNQASYDRACVHGFIDALDGTAYQTLPWNHRGWHGGGSSNDTHIGVEMCEPACIKYTTGSSFTCSDMAEAKACAARTYNTAVELFAMLCEKFGLNPLADGVIVSHREGHARGIASNHGDPEHLWSGLGMSYTMDGFRKDVKAKMGGSSAPSNGTQATVFAGLSEKDAVSKIGELCRKDMKSGGVLASVSAAQFILESGYGKSELAQNANNCFGMKKSLSGNTWSGSAWDGKSIYTKKTQEQNKDGSYVTITADFRKYPSVEKSVADHSAYLLGAKNGDKLRYVGLKGCTDYKKAAQLIKDGGYATSLTYVEKLCSIIEKWNLTQFDGKAADAPVKNPDTVTTFPTVPFLVKVIIDDLNYRSEPSMNGKVNGQTGKGTFTIVEVRDGWGRLKSGAGWIWLCNPSYCIVGGKVTSAQTPSKSIEELAREVIQGKWSNGEERKQKLKAAGYDYSAVQKRVNELLK
Physico‐chemical
properties
protein length:505 AA
molecular weight:54765,4 Da
isoelectric point:8,96
hydropathy:-0,40
Representative Protein Details
Accession
2fXJB
Protein name
2fXJB
Sequence length
403 AA
Molecular weight
43519,03700 Da
Isoelectric point
9,10979
Sequence
MKIIQSILTSNPCYKAGRKITVKGLMLHSVGCPQPSASVFVKNWNRSSFNSACVHAFIDGNTGDVYQTLPWNHRGWHGGGSSNNTHIGVEMCEPACIKYTGGATFTCSNLPVARAVAQRTYDTAVQLFAHLCTTYNLDPLADGVIVSHKEGHKRGIASNHGDPEHLWNQLGMGYTMDTFRKAVSAAMGGDSAGDEPAPDTAEKVLYRVQVGAYKVKKNADAQLAKVKAAGFDTYMVKVDGLYKIQTGAFSKKANAEAQLAKVRAAGFSAFITTKSGEVVNWWDDIKYFKRSEFACKCGKHCNGYPVEPAEDLVKLLDQIRAHFGKPCIVNSGIRCEKHNTAVGGASASQHLYGKAADIATISGTTPAKMAAYVETLMPNSGGIGIYSWGIHVDIRSTKSRWNG
Other Proteins in cluster: phalp2_25374
Total (incl. this protein): 5 Avg length: 390,4 Avg pI: 9,08
Protein ID Length (AA) pI
2fXJB 403 9,10979
1gC2l 300 9,02159
A0A345BPY8 453 9,51703
A0A8S5T4Q1 291 8,76598
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_39586
6nEZG
 27 56,7% 280 5.373E-97
2 phalp2_16415
6dOiM
 26 37,7% 344 6.833E-48
3 phalp2_27209
3o7E3
 7 31,9% 269 6.716E-22
4 phalp2_3987
7ylun
 65 25,5% 333 1.709E-18

Domains

Domains [InterPro]
Ami2
SPOR PET_M15
Representative sequence (used for alignment): 2fXJB (403 AA)
Member sequence: A0A8S5LSC7 (505 AA)
1 403 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510, PF05036, PF08291

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctMAv2
[NCBI] 		2826258 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK014727 [NCBI]
CDS location
range 69922 -> 71439
strand -
CDS
ATGAATTTAGTACAGCATTTTTTAACAAACAATCCTTGTTATAAAGCAGGGAGAAAGATTACAGTCAAAGGACTTATGTTACACTCAGTTGGATGCCCACAGCCAAGGGCATCTGCATTTATAAACAGCTGGAATCAGGCATCTTATGACCGTGCCTGTGTGCATGGTTTTATTGATGCTTTAGACGGAACGGCTTATCAGACACTTCCGTGGAACCACAGGGGTTGGCATGGTGGAGGCTCATCAAATGATACTCATATCGGTGTGGAAATGTGTGAACCTGCTTGTATCAAGTATACGACAGGCTCTTCTTTTACCTGTTCTGATATGGCAGAGGCAAAAGCGTGTGCTGCAAGAACTTATAATACAGCAGTAGAGTTATTTGCTATGCTATGTGAGAAGTTTGGACTTAATCCGTTAGCAGATGGTGTGATTGTATCCCATAGAGAAGGTCATGCGAGAGGCATCGCATCAAACCATGGTGACCCGGAGCATCTTTGGAGCGGTCTGGGTATGAGTTACACAATGGATGGATTTCGCAAGGATGTCAAAGCTAAGATGGGTGGATCATCTGCTCCAAGTAATGGAACACAAGCTACAGTGTTTGCAGGACTTTCCGAAAAGGATGCCGTGTCGAAAATCGGAGAATTATGTCGAAAGGATATGAAATCAGGTGGTGTACTTGCATCTGTCTCTGCAGCACAGTTTATTCTTGAGAGCGGATATGGAAAAAGTGAACTTGCACAGAATGCCAATAACTGCTTTGGCATGAAGAAATCCTTATCCGGCAATACTTGGAGTGGCTCTGCATGGGATGGCAAGAGTATTTATACGAAGAAAACACAGGAGCAGAACAAGGATGGTTCTTATGTAACTATTACAGCGGATTTCAGAAAGTATCCATCTGTGGAGAAATCTGTCGCAGACCATTCAGCATATCTGCTTGGAGCTAAGAATGGAGATAAGCTTCGTTATGTAGGTCTAAAGGGATGCACTGACTATAAGAAAGCAGCACAACTTATCAAGGATGGTGGATATGCTACAAGCCTTACTTATGTAGAGAAACTCTGCTCCATCATTGAAAAGTGGAATCTGACACAGTTTGATGGAAAGGCAGCAGATGCGCCTGTAAAGAATCCGGATACCGTGACAACATTTCCTACTGTTCCATTTCTGGTAAAGGTCATCATTGATGATTTGAATTACAGAAGTGAGCCTTCTATGAATGGCAAGGTAAATGGTCAGACTGGCAAGGGAACCTTTACAATCGTTGAAGTAAGAGATGGCTGGGGAAGACTTAAGAGTGGTGCAGGATGGATTTGGCTTTGCAATCCTTCCTACTGCATAGTAGGCGGCAAAGTTACATCTGCACAAACACCATCCAAGTCGATTGAGGAACTTGCCAGAGAAGTTATCCAGGGAAAATGGAGTAATGGAGAAGAAAGAAAGCAGAAGTTGAAAGCTGCAGGATATGATTATTCTGCTGTGCAGAAGAGGGTCAACGAACTCTTGAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0004040 amidase activity molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (2fXJB) rather than this protein.
PDB ID
2fXJB
Method AlphaFoldv2
Resolution 92.85
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50