Protein

Protein accession
A0A8S5LMX3 [UniProt]
Representative
8bLgC
Source
UniProt (cluster: phalp2_8690)
Protein name
NlpC/P60 family
Lysin probability
100%
PhaLP type
endolysin
Probability: 96% (predicted by ML model)
Protein sequence
MITTAGATSEPNGYIINEATLYSGPSYNASSYATLSVGTEICVYGNYRQWYEIGWNGKIGYVLSEYVSIDHKQDYTITIDATPVPIAPVDTSSNIPMEPAPSEPTATSTPTPTPAPSGNTSIIESAEAYLGVPYKWGGTTDKGFDCSGFVQKAYKDAGYSIGRTTQLQALEGEEVEDYAPGDILCFGHSKWNIFHTGIYIGDGKFIHASSPEGVIVSDLDDYGLKLIMARRVG
Physico‐chemical
properties
protein length:233 AA
molecular weight:25068,5 Da
isoelectric point:4,50
hydropathy:-0,24
Representative Protein Details
Accession
8bLgC
Protein name
8bLgC
Sequence length
260 AA
Molecular weight
28105,37600 Da
Isoelectric point
4,77552
Sequence
MVLKKIILFIVICAIALTIPAYCAYYGTITSNDVNFRSGPSDNSTIYYSLSNGKSVIVRGTCGGGNKWYEIECDGKIGYVYADYVSFNSNSEKVIYTEENEPILAELAKPAPTQTPAISPTPGPTVSPTPTPTPGVKNDPDASDVITNAQKYLGTPYQWAGSSPDDGFDCSGFVQYVFAESGYTIKRVAQEQADTAGVEVNEMAPGDILCFGSSQYNIWHVGIYIGDNQFIHSSPMGGVIISELSKYDLRLIKIKRVAGV
Other Proteins in cluster: phalp2_8690
Total (incl. this protein): 29 Avg length: 227,3 Avg pI: 5,10
Protein ID Length (AA) pI
8bLgC 260 4,77552
2IdT 254 4,73806
3h7fh 246 4,59347
3v6d3 294 8,83251
3vHH8 256 4,72948
5LAxM 256 4,99458
5W3g3 259 4,82150
5Xu0x 259 4,90977
60oex 256 4,91358
63WZH 233 4,49815
65ymQ 254 4,82111
683V4 252 4,91506
68GTI 191 4,50036
6d4g6 256 4,75023
6efhD 250 4,90165
6g6UV 256 5,01669
6tpUO 254 4,89784
6uXRy 256 4,75023
6v3XR 257 4,62603
7WEd5 253 5,03942
8bAAj 254 5,01862
8bLsC 259 4,92512
8kn84 255 5,05074
A0A8S5NZ17 108 5,83960
A0A8S5PAE7 108 5,83960
A0A8S5SP92 108 5,48891
A0A8S5UEN6 108 5,49340
A0A8S5UWG5 108 5,79436
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_11039
7DN8Z
 1 38,8% 234 1.335E-52
2 phalp2_16425
6tfHg
 3 27,6% 242 1.019E-23
3 phalp2_16500
6Vabz
 2 29,4% 173 2.879E-20
4 phalp2_22894
2Sg1U
 2 29,8% 164 6.026E-19

Domains

Domains [InterPro]
Disordered region
SH3_3
NLPC_P60
Representative sequence (used for alignment): 8bLgC (260 AA)
Member sequence: A0A8S5LMX3 (233 AA)
1 260 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00877, PF08239

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctsf32
[NCBI] 		2827594 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015882 [NCBI]
CDS location
range 38156 -> 38857
strand +
CDS
TTGATTACTACAGCGGGAGCCACTAGTGAGCCTAATGGATACATAATCAACGAAGCAACTTTGTATAGCGGACCCAGTTACAATGCTAGTAGCTATGCAACGCTCAGTGTAGGGACAGAGATTTGTGTTTACGGGAATTACCGTCAGTGGTATGAAATTGGCTGGAATGGAAAGATCGGATATGTGTTAAGTGAGTATGTGTCTATTGACCATAAGCAAGACTACACAATTACTATTGATGCAACACCTGTGCCTATTGCGCCAGTAGATACTTCATCCAATATACCGATGGAGCCCGCGCCGAGTGAACCGACTGCTACATCAACTCCCACACCTACTCCTGCACCTTCAGGCAACACATCTATTATAGAAAGTGCAGAAGCCTATCTTGGCGTCCCTTATAAGTGGGGTGGAACTACTGATAAGGGATTTGACTGTAGTGGTTTTGTCCAGAAAGCCTACAAAGATGCAGGATACTCTATTGGACGTACCACTCAACTTCAAGCTCTTGAAGGTGAAGAAGTTGAAGACTATGCACCGGGAGACATTTTATGCTTTGGGCATAGTAAGTGGAATATTTTCCATACGGGAATATATATAGGCGATGGAAAGTTTATTCATGCATCCTCTCCGGAAGGAGTTATTGTGAGTGATCTTGACGACTATGGATTGAAACTTATTATGGCGAGACGAGTAGGCTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008234 cysteine-type peptidase activity molecular function None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8bLgC) rather than this protein.
PDB ID
8bLgC
Method AlphaFoldv2
Resolution 74.62
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50