Protein

Protein accession
A0A8S5LHS6 [UniProt]
Representative
13rhz
Source
UniProt (cluster: phalp2_38736)
Protein name
PlyB like endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MSKCYASAVLKVAEGEIGYLEKASNSQLDDKTANAGNKNYTKYARDFDQKYPSWYNGKKNGFAWCDMFVDWCMLTAFGYTEALRLLCQPEHSAGAGCTYSLMYYKQKGQYHASNPKPGDQIFFGTSTTNVSHTGLVEKVDATKVYTIEGNTSDKVARRTYSLSDKKIVGYGRPAYDAEKDVSGGSQAVTEPVQKSSTGSSTVYTVVWGDTLSKIAAKYGTTVKAIADLNGIKNVNRINVGQKLTIPGGSSTPAKTTVQHTVVRGDTLWALASRYLGAGSKYRQIMIENGLTSTTIRVGQVLNITK
Physico‐chemical
properties
protein length:305 AA
molecular weight:33219,1 Da
isoelectric point:9,30
hydropathy:-0,43
Representative Protein Details
Accession
13rhz
Protein name
13rhz
Sequence length
495 AA
Molecular weight
53768,54610 Da
Isoelectric point
5,84961
Sequence
MSVKIKGVDVSKWQGSIDWARVARDGVKFAMVRLGYGSKDGTACGVDSYYQKNVEGALKNGIAVGCYFYSYALSVEAVKREAAFVIQQLAQYKGRILYPIAFDIEDNSQAGLGRNTLTAMVTAFCSALEAAGYYASFYCNLNWAKNMLDMSVLARFDFWLAQWASAPTYSGHGFNMWQSSSKGAVAGISGNVDMDTAFVDFEAVIKERGLNGYTGAAPQPEAKPGKGCYASAVVAVAAGEIGYLEKETNSQLDDKTANAGDENFTKYARDFDQKFPAWYNGKKNGFAWCDMFVDWCFLTAFGYENALRLLCQPERSCGAGCTYSLSYYRNRGQFHTSNPEPGDQIFFGNSINSSSHTGIVEKADGSRVYTIEGNTSDRVARRSYALNDSKIIGYGRPAYDAEAAPSAPVTPSNPPQKTVDELVDEVLAGQWGNGQERKNRLTAAGYDYATVQDAVNARCAAQKAAEKLAQDIAAQLKSSGCDAAAVLKRVNEILA
Other Proteins in cluster: phalp2_38736
Total (incl. this protein): 58 Avg length: 493,4 Avg pI: 6,43
Protein ID Length (AA) pI
13rhz 495 5,84961
137sR 557 7,89095
1ctnl 558 8,64200
1jEgk 556 8,74889
21n9J 450 8,49089
2m98H 479 6,05696
38FE1 619 8,72562
3ZyrD 663 8,52100
3p9Mw 479 5,71814
3pIJL 479 5,29247
3pfE1 479 5,58963
3snIK 479 5,55910
3uZeJ 479 5,48464
3vD4Q 479 5,71814
3vFFT 479 5,87627
3vKI7 479 5,48078
3xQeD 447 6,99821
4VVdu 545 7,81159
4z6Vh 479 5,58451
5KtQm 479 5,72121
5MOZL 479 5,72121
5Mm7D 479 5,57945
5Of3b 489 5,97272
5OjRd 479 5,58457
5PT0P 479 5,55069
5PaIo 479 5,81585
5RuUO 479 5,48072
5TEgE 479 5,45060
5VVJL 476 5,48078
5W9ur 479 5,87257
5Z6Av 479 5,72121
63LvA 479 5,55211
65zEy 479 5,46975
66m8t 479 5,47532
67qrI 545 6,83775
6UPXD 639 8,30548
6bVnt 479 5,58457
6csYO 479 5,87257
6d1yQ 479 6,05696
6eZfV 479 5,55069
6ghKT 479 6,05696
6gjDx 479 5,87627
6gjzg 531 7,46713
6h90h 479 5,67386
6hURf 479 6,93819
6iAuJ 479 5,66954
6ih1L 479 5,37233
6l4vA 479 5,44668
6mcFS 479 5,72558
6o5Tq 479 5,55069
6rZDl 479 5,58457
6tWSe 479 6,34900
8pHHH 532 8,67288
8pzJT 479 5,48464
a1J6 531 9,18483
gs0Y 499 8,85797
nhin 500 9,04886
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_4916
6k3vw
 208 35,6% 463 2.312E-114
2 phalp2_2377
7JCYq
 91 28,4% 447 4.817E-107
3 phalp2_34377
4dm6y
 15 44,2% 411 1.826E-99
4 phalp2_4009
11iJK
 7 28,7% 536 1.419E-92
5 phalp2_6929
2LVGE
 3 35,4% 313 9.670E-90
6 phalp2_38640
41jQJ
 13 36,7% 408 2.157E-88
7 phalp2_16417
6gC98
 231 34,9% 443 8.890E-80
8 phalp2_34762
3ij83
 364 34,3% 439 7.753E-79
9 phalp2_39103
2m4j4
 107 29,0% 337 2.326E-77
10 phalp2_1134
5riG
 24 31,1% 443 5.114E-76

Domains

Domains [InterPro]
GH25
CHAP
CW_7
Representative sequence (used for alignment): 13rhz (495 AA)
Member sequence: A0A8S5LHS6 (305 AA)
1 495 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF05257, PF08230

Taxonomy

  Name Taxonomy ID Lineage
Phage Myoviridae sp. ctbwh6
[NCBI] 		2827611 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK015852 [NCBI]
CDS location
range 889 -> 1806
strand -
CDS
ATGAGTAAATGTTACGCATCCGCCGTCCTGAAGGTAGCTGAAGGCGAAATCGGCTATCTGGAGAAGGCGTCCAACAGCCAGCTCGACGACAAGACCGCCAACGCTGGAAATAAGAACTACACCAAGTATGCCCGTGACTTCGACCAGAAGTACCCCTCTTGGTACAACGGCAAGAAGAATGGCTTCGCTTGGTGCGATATGTTCGTGGACTGGTGTATGCTGACCGCTTTCGGCTACACGGAGGCTCTGCGGCTGCTTTGCCAGCCTGAGCACTCCGCCGGAGCCGGATGCACCTACTCCCTGATGTACTACAAGCAGAAGGGACAGTATCACGCAAGCAACCCGAAGCCCGGAGATCAGATTTTCTTCGGAACCTCCACGACCAATGTCAGCCACACCGGTCTTGTGGAGAAGGTGGACGCCACGAAGGTCTACACCATCGAGGGCAACACCAGCGATAAGGTCGCAAGACGCACATATTCGCTCTCTGACAAAAAGATTGTCGGCTATGGGCGTCCGGCTTACGATGCCGAGAAAGACGTTTCTGGAGGCTCTCAGGCGGTAACAGAGCCTGTTCAGAAGTCGTCTACCGGAAGCAGCACCGTCTACACCGTCGTTTGGGGAGACACGCTCTCCAAAATCGCCGCCAAGTACGGCACAACCGTGAAGGCGATTGCCGACCTGAACGGCATCAAGAATGTAAACCGCATCAACGTCGGTCAGAAGCTGACCATCCCCGGCGGCAGTAGCACCCCGGCTAAGACGACTGTTCAGCACACGGTCGTCCGAGGCGATACACTGTGGGCACTGGCATCCCGGTATCTCGGCGCAGGCTCAAAGTATCGCCAGATTATGATCGAGAACGGACTGACCTCGACCACCATCAGGGTCGGGCAGGTCCTGAACATCACGAAGTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008932 lytic endotransglycosylase activity molecular function None (UniProt)
GO:0016787 hydrolase activity molecular function None (UniProt)
GO:0071555 cell wall organization biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (13rhz) rather than this protein.
PDB ID
13rhz
Method AlphaFoldv2
Resolution 88.14
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50