Protein

Protein accession
A0A8D9UHC2 [UniProt]
Representative
3rB1
Source
UniProt (cluster: phalp2_36261)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MVHSTGCNNPNLKRYVQPSTNDSNYNTLISQLGKNNGGTAWNKSNTNVCVHAFIGKLANGEIATVQTLPWNYKGWHCGKGNKGSRNLSHISFEMCEDSLSDTNYFNKVYKEAVEFAAYLCQLYNFDPLADGVIIGHYEGHQRGIASNHADPRNWFPRFGKSMDTFRQDVAAKMGKVIPVAPSNTEITVSYSGVVTASVLRIRKGPSVSSSIAGTLKKGTVVSIILEDNGWGKLADGSGWVSLTYIKKSATSVKTFKNYKGKITASSGVNIRTGAGINYNKNGAVTYNSVVTIVDEE
Physico‐chemical
properties
protein length:296 AA
molecular weight:32179,9 Da
isoelectric point:9,35
hydropathy:-0,36
Representative Protein Details
Accession
3rB1
Protein name
3rB1
Sequence length
371 AA
Molecular weight
39973,68800 Da
Isoelectric point
9,26477
Sequence
MNLRKLIFTNNACYKAGRTIAVKGIMVHSTGANNPNLKRYVGPDDGLLGQNQYGNHWNQDKPDQRQVCVHGFVGKLADGSIATYQTLPWNHRGWHGGSGSKGSVNDTHIGFEICEDGLTDAVYFRKVFNEAVELCVHLCKEYNLNPMKDGVIIGHYEGYQRGIASNHGDPKNWFPKHGESMDSFRAAVKKGMGTTITPPAPSEPTPPSPTPGSIAEGSLVAFKSGTKNYYPGSTAVPAWVLTEYNHTVTQTTSGGKAVVKGGKTCVLLGKKTHKKTGKEEAGINTWVDKDVLELVGTAPAPAPAFTAYTVKVTASELNIRKGPGTNYGTNGSIKDKGVYTIVEESTGQGATKWGKLKSGAGWISLNYCQKR
Other Proteins in cluster: phalp2_36261
Total (incl. this protein): 176 Avg length: 358,2 Avg pI: 8,70
Protein ID Length (AA) pI
3rB1 371 9,26477
10GN9 358 9,50665
138BO 448 9,06337
13I8i 530 9,27547
13cfH 486 8,70512
13e1O 248 8,87377
13oYO 240 9,27689
13t85 352 9,09702
13v29 472 8,94249
13vvk 472 8,34190
14Jwt 532 9,39428
14uPt 530 9,35593
14yof 248 9,53321
14yyJ 345 9,16278
19fHK 350 8,93211
19mjO 348 8,77107
1FZx5 458 9,29339
1FjMg 482 8,52602
1FjhG 381 9,32949
1G2xp 357 6,62302
1Gejz 319 8,41868
1Gfke 345 9,20991
1Hwkn 346 9,23240
1NA3q 334 4,41727
1NB4K 324 4,74790
1Z2BA 530 9,15130
1gEBk 268 8,59881
1gHtP 333 6,71168
1igc9 290 9,42749
1kZ36 409 8,21161
1nXmo 472 8,97917
21GcI 473 7,02419
21HCn 491 8,80782
21eX4 357 7,46639
21jg3 374 8,80678
21mnO 305 6,65581
21pC8 394 7,84943
232zm 380 9,45817
2354G 359 6,23469
238C5 388 9,76814
23F08 391 9,20610
24Cho 299 8,89311
24K26 316 8,91374
24pQA 361 7,01719
24rdW 374 9,23692
2GFVe 316 9,55255
2GFxN 530 9,26045
2H9dh 466 9,14183
2JrDS 247 9,36934
2XvUk 529 9,21796
2amdy 318 9,67395
2anen 238 8,92676
2bAOG 481 8,80575
2bXVz 479 8,78145
2c9Wf 479 8,40618
2dbAF 477 8,41121
2dci1 348 9,35406
2mtVV 355 9,16052
2mtpM 477 8,45259
2nY4f 400 4,96258
2oFZY 268 9,12326
2olST 347 9,17780
35zjq 357 7,69494
38Li4 305 9,23769
3PDCn 339 9,13873
3PXeX 485 7,22204
3Q1Cz 337 8,81304
3Q2yZ 312 9,35283
3TFzb 394 8,96241
3TKfs 324 9,48944
3TL82 297 8,91026
3aoxQ 276 8,99581
3bWsP 356 9,03346
3dXjT 280 9,06176
3dZeC 324 6,10544
3e6bX 347 9,27611
3eNVT 240 8,82774
3f8Xb 347 9,27611
3fRbP 374 5,57729
3ibCZ 479 8,75521
3ix6O 376 5,41632
3iyNU 403 8,30838
3iyP1 362 9,09012
3iyj3 373 5,90326
3nCKN 482 8,74889
3nDi8 360 9,17799
3nTKj 257 9,36257
3nyKX 276 8,98672
3nyx3 352 5,29480
3o6A4 348 8,78338
3qufe 311 9,23221
3tgEP 470 8,85436
3uPiU 352 9,04383
3v5yT 568 5,36199
3vGaP 358 9,13312
3vJCy 496 9,30003
3vm9z 346 9,19804
3vpYo 347 9,34606
3whtG 274 9,43110
3y2P4 470 8,92444
40EJO 456 5,48715
41bqV 401 8,44280
41gcO 302 7,50112
4CvHg 485 8,65973
4FQfs 240 9,13822
4L0Sy 289 9,13938
4NPhr 532 9,32614
4SEna 346 9,42413
4UG5V 244 9,37166
4UeGs 461 9,06737
4Uexp 554 9,45173
4ZHSq 530 9,20565
4ZHWp 484 9,32827
4d0Y 453 8,20046
4lvQP 372 9,37249
4m0VL 246 9,59936
4muwf 530 9,21777
4ugDh 530 9,14292
4y62D 273 9,14615
4y6Hw 333 9,19624
4ypJe 339 9,12087
5RBRQ 275 9,30010
5Vk1W 229 9,67685
5Vlwa 257 8,97659
5YCE0 289 9,59394
5ZYis 255 9,70541
64h0e 260 9,05460
65pHr 257 9,06169
6633 452 4,38856
664Yr 229 9,63449
668az 280 9,46346
66E5u 304 9,44663
66dCx 326 9,35941
69LhQ 257 8,98433
69dRe 275 9,14499
69rwu 289 9,41008
69tS 429 8,79815
6UJO9 243 9,35896
6WXIs 240 9,33478
6cW9A 289 9,28353
6dEJT 289 9,37353
6eI0a 271 9,19585
6fLto 255 9,72224
6h5fP 257 8,97659
6hu4M 339 8,52893
6j4M1 271 9,30003
6l9l5 231 9,67711
6lLco 348 9,25323
6nhR3 257 9,02978
6rZQH 278 9,46365
6s93s 257 8,97659
6sTHB 276 9,46352
6tssF 257 9,11352
6uRwx 276 9,50156
6uxdY 458 9,15665
6wGd 530 9,19688
7YnfR 338 8,05702
7gF2l 240 9,32311
80AW 332 8,87022
80PmT 401 8,77146
81MS 316 9,63391
82G2I 319 6,51138
83GXL 265 9,35754
84SDk 277 8,98568
86WL6 346 9,15904
86vL2 333 8,33797
8kSBi 302 8,92044
8r4hm 401 9,00303
8rhar 381 9,22596
8uXjP 333 7,60633
9x1H 356 8,58289
OyRY 301 9,09734
lDf9 503 8,55549
ojEb 290 9,39854
ovm5 273 5,38938
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_10292
1gBJ2
 1 37,8% 383 7.002E-114
2 phalp2_17183
3bJIf
 458 52,5% 312 1.589E-103
3 phalp2_31507
3VJ9A
 7 34,0% 347 1.266E-98
4 phalp2_39111
2nYlj
 83 42,7% 372 4.436E-98
5 phalp2_14240
38OZD
 1 26,3% 425 4.199E-78
6 phalp2_17387
4JZWC
 1 36,2% 397 7.535E-75
7 phalp2_32070
5P7Lm
 156 36,6% 325 5.621E-60
8 phalp2_21402
41nmU
 1 30,1% 282 6.732E-59
9 phalp2_10091
5D9X
 97 26,1% 551 4.529E-56
10 phalp2_9562
1gEae
 1 27,4% 401 1.531E-44

Domains

Domains [InterPro]
Ami2
Unannotated
Unannotated
Representative sequence (used for alignment): 3rB1 (371 AA)
Member sequence: A0A8D9UHC2 (296 AA)
1 371 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Bacteriophage sp
[NCBI] 		38018 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BK029940 [NCBI]
CDS location
range 70262 -> 71152
strand -
CDS
ATGGTTCATAGTACTGGTTGTAATAACCCCAATTTGAAAAGATATGTACAGCCTTCTACTAATGATAGTAATTATAATACTTTGATTTCGCAGCTTGGTAAGAATAACGGTGGTACTGCTTGGAATAAATCTAATACGAATGTTTGTGTTCACGCTTTTATTGGTAAACTTGCTAATGGTGAAATTGCTACGGTGCAAACATTGCCTTGGAATTACAAAGGTTGGCATTGTGGCAAGGGAAATAAAGGAAGTCGGAATTTATCGCATATCAGTTTTGAAATGTGCGAAGATAGCTTAAGCGACACAAATTATTTTAACAAGGTTTACAAAGAAGCTGTTGAATTTGCAGCTTATCTTTGTCAGCTTTATAATTTTGACCCACTTGCAGATGGCGTAATTATTGGCCACTATGAAGGACATCAAAGAGGTATCGCTTCTAATCATGCTGACCCCCGTAATTGGTTCCCTCGTTTTGGTAAAAGTATGGATACTTTTAGACAAGATGTTGCTGCTAAGATGGGCAAGGTAATTCCTGTTGCGCCTTCTAATACCGAAATCACTGTGTCTTATTCTGGCGTTGTTACCGCTTCTGTTTTGAGAATTCGTAAGGGGCCTTCTGTTTCCTCTTCTATTGCTGGAACTCTTAAAAAGGGAACGGTTGTTTCTATTATTCTTGAAGATAATGGTTGGGGTAAGTTGGCTGATGGTAGTGGTTGGGTAAGTTTAACTTATATTAAAAAGAGTGCTACTTCAGTTAAGACCTTTAAAAATTACAAAGGTAAAATTACAGCATCTTCTGGTGTCAACATAAGAACTGGTGCTGGTATTAATTACAATAAAAATGGAGCTGTAACTTATAATTCTGTCGTAACTATTGTTGACGAGGAATAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (3rB1) rather than this protein.
PDB ID
3rB1
Method AlphaFoldv2
Resolution 89.69
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50