Protein

Protein accession
A0A873WDU5 [UniProt]
Representative
6Tgy0
Source
UniProt (cluster: phalp2_12233)
Protein name
Endolysin glycoside hydrolase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKLVTRAQWGAREPDNGHDVVTSNYGVKVHYLGSPYSVGDHSTCAAYMRKLQNDHMDGNGWADFAYNFGVCEHGYVFEGRGLNAQNAANGNTTLNRNHFAVLAFVGSSGHTSPTADQVQGLKDAIGYLRAHGAGNEIKGHKDGYATACPGGPLYTMVHNGSLEPGTSGGGGGGTTPSRAQVTINGLVYGYDAYGEHVTTVGTALVSKGFGKHYTDGPGPRWTDADTLNYADFQRSLGFTGSDADGVPGPSSLKTLLGYLPGTATVAPAAYEPFPGVKFFQKKPDSKVVTAMGKRLVAEGCSAYASGPGSKWTNADRESFKKWQRKLGDAAAYCDGWPGKRQWDALKVPKVK
Physico‐chemical
properties
protein length:351 AA
molecular weight:37211,9 Da
isoelectric point:8,76
hydropathy:-0,50
Representative Protein Details
Accession
6Tgy0
Protein name
6Tgy0
Sequence length
193 AA
Molecular weight
21022,29400 Da
Isoelectric point
9,25033
Sequence
MAIKLVSRAAWGARAYRQPSGGTLYTGKRRGVKLHYLGTAYSDRTHDRCDDYVRQIQAQHMDGNGWSDIGYSFVVCTHGYVYEGRGLRRRNSANGNTTLNNQDYAVLMMVGSSGLTRPTDAQLHGARDAIDYCRKEGPAGTWLGGHRDGYATTCPGEPIYAWARAGAPRPANLGLDHSGDPLLVVVGQGHVVL
Other Proteins in cluster: phalp2_12233
Total (incl. this protein): 57 Avg length: 225,0 Avg pI: 7,84
Protein ID Length (AA) pI
6Tgy0 193 9,25033
19q7g 186 6,20502
1FC98 166 10,07900
1IsKs 232 6,38020
1Wac9 200 8,81897
1lTRd 255 6,13187
1pbnX 273 8,94030
2JKt 269 8,93998
2YVp 182 9,48892
3Lvf3 266 5,31589
3NZJi 248 7,77684
3PuaF 248 6,91403
3PuhC 252 8,37375
3g8Dr 215 9,24382
40z13 185 8,66844
4F43k 206 4,57431
4JkvV 246 6,38566
4JlFU 273 7,76895
4LAnx 287 9,77684
4QxvM 313 5,87916
4T3jY 288 7,95367
4T3nm 287 6,65712
4dUhy 175 10,33314
4kQyV 243 5,10524
4rBcy 178 9,45269
4vHok 169 8,21735
5B23Z 271 9,07349
5Doiw 185 10,18376
5GXpO 233 4,40385
5H9vG 251 8,81832
5I6Hg 171 10,76585
6CCDb 231 5,02328
6LjNy 233 4,48877
6SMjE 259 9,51304
6SZXA 172 11,25774
6T82N 275 5,69080
6T8Ij 242 8,78712
6T97t 144 9,47306
6Tg4M 177 10,09705
6ThRF 227 7,20851
726Kq 234 5,98739
7CE3E 228 5,01731
7zimZ 241 5,69512
8AM8e 197 9,63359
8C64Q 187 7,02112
8Cm5r 211 7,00264
8EBHG 195 9,06027
8EZOR 195 9,06027
8wkla 197 9,68446
QNSl 187 10,76031
QPfr 241 7,21073
QiNZ 179 5,92634
Rjf7 200 8,57057
blwy 243 5,09217
kdUI 169 9,98378
ty5e 266 4,72368
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_36432
11r0n
 207 57,3% 176 1.179E-62
2 phalp2_39895
1eEek
 97 55,6% 187 1.329E-60
3 phalp2_13951
8FOsh
 28 32,7% 174 1.231E-56
4 phalp2_15099
bgFu
 21 37,7% 172 2.005E-42
5 phalp2_15382
1LWAy
 5 39,7% 161 3.760E-42
6 phalp2_15057
7s7pP
 172 34,5% 165 8.708E-41
7 phalp2_5539
3EPBj
 12 30,7% 169 3.776E-39
8 phalp2_26274
RjMA
 376 31,1% 170 3.064E-37
9 phalp2_6619
1rf3V
 4 33,5% 170 3.064E-37
10 phalp2_23216
7DAyW
 82 34,2% 187 8.697E-35

Domains

Domains [InterPro]
Unannotated
Disordered region
Representative sequence (used for alignment): 6Tgy0 (193 AA)
Member sequence: A0A873WDU5 (351 AA)
1 193 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage Streptomyces phage Sycamore
[NCBI] 		2767589 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MT701593 [NCBI]
CDS location
range 16176 -> 17231
strand +
CDS
GTGAAGCTAGTTACTCGCGCACAGTGGGGAGCACGTGAGCCGGACAACGGCCACGACGTGGTTACGTCCAACTATGGCGTCAAGGTGCATTACCTCGGTTCCCCGTACAGCGTGGGCGACCACAGCACGTGTGCCGCGTACATGCGCAAGCTACAGAACGACCACATGGACGGGAACGGTTGGGCTGACTTTGCCTACAACTTCGGTGTCTGCGAACACGGTTACGTGTTTGAGGGCCGAGGGCTCAACGCGCAGAACGCAGCGAACGGGAACACCACGCTAAACCGCAACCACTTTGCGGTACTGGCGTTCGTCGGTTCCTCGGGCCACACCTCCCCCACCGCTGATCAGGTGCAGGGGCTTAAGGACGCTATCGGCTACCTGCGCGCACACGGTGCCGGTAACGAGATCAAGGGCCACAAGGACGGTTACGCGACCGCTTGCCCCGGTGGTCCGCTCTACACCATGGTTCACAACGGTTCGCTAGAGCCGGGTACCTCGGGTGGTGGCGGTGGCGGTACTACTCCGTCCCGCGCACAGGTCACCATCAACGGTCTCGTCTACGGCTACGACGCGTACGGCGAGCACGTGACCACGGTCGGAACTGCGCTTGTTTCCAAGGGCTTTGGCAAGCACTACACCGACGGTCCGGGCCCGCGCTGGACCGACGCTGACACTCTCAACTACGCAGACTTTCAGCGGTCGCTAGGCTTCACCGGCTCGGATGCTGACGGCGTTCCCGGTCCGTCCAGCCTCAAGACCCTACTCGGCTACCTGCCGGGTACGGCCACCGTCGCCCCGGCCGCTTACGAGCCGTTCCCCGGTGTGAAGTTTTTCCAGAAGAAGCCTGACAGCAAGGTTGTAACTGCCATGGGCAAGCGCCTTGTTGCCGAGGGTTGCTCGGCCTACGCGTCCGGCCCTGGTTCCAAGTGGACCAACGCTGACCGTGAGTCGTTCAAGAAGTGGCAGCGCAAGCTAGGCGACGCCGCCGCGTACTGCGATGGCTGGCCCGGTAAGCGTCAGTGGGACGCACTAAAGGTCCCGAAGGTTAAGTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008270 zinc ion binding molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (6Tgy0) rather than this protein.
PDB ID
6Tgy0
Method AlphaFoldv2
Resolution 91.16
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50