Protein

Protein accession
A0A6J5MA41 [UniProt]
Representative
1HOCY
Source
UniProt (cluster: phalp2_4134)
Protein name
N-acetylmuramoyl-L-alanine amidase domain containing protein
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MKLTQTAFSANQYIADERPKRQIYIHHTAGNADPFGVFKFWESNRERIATCVTIGGKPRRGSNWQDGEVVQGYSSRFWAFHLGLTESTFQKFNVPYISLDKISIGIEICNWGQLTLKNGKFYNWANGEVPADEVCELKTEHRGFKYYHNYTDAQIDAVKDLLLLWKQRYNIPLEYHADIWDVTPRALRGEAGVFTHNSVRYDKVDVYPHPKLVSMLKSL
Physico‐chemical
properties
protein length:219 AA
molecular weight:25382,4 Da
isoelectric point:8,64
hydropathy:-0,50
Representative Protein Details
Accession
1HOCY
Protein name
1HOCY
Sequence length
326 AA
Molecular weight
37624,22390 Da
Isoelectric point
8,54627
Sequence
MEKLDLKKIKQVEFNDSEYIRTATTKTQIVLHHTAGNSSGVNTIRAWNNDQRGRIATCVVISGKGSSNSHDGEICQAFSSKYWAYHLGVKNESFASKNVVYRRLDPGAIGIEICNWGALTKKGEKYYNYVNREVPAEEVCILKTKYKGFKYFHKYTEAQIESVRQLLVYWNEIYNIPLDYKESEMWDLSEDALSGVPGIYTHNSYRADKSDISPQPQIIEMLKNLNKENMAKQKPKEIKVEAEIDGNKLSIEKDQDGIDVVYDGKNRDVEFHKSEEEKSFKYDGKKLDIEVNKTKDKTEIDIQAETSLLRWFGKIISKFVLKKFKK
Other Proteins in cluster: phalp2_4134
Total (incl. this protein): 3 Avg length: 252,3 Avg pI: 8,24
Protein ID Length (AA) pI
1HOCY 326 8,54627
A0A6J5SLR1 212 7,53744
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_14005
87m9T
 1656 58,0% 231 1.208E-88
2 phalp2_35105
5kI8h
 32 41,9% 224 7.941E-55
3 phalp2_28209
iKDC
 1185 41,2% 223 1.015E-51
4 phalp2_11040
7EhAU
 132 44,3% 212 5.759E-50
5 phalp2_40162
8puc9
 1 38,6% 225 3.255E-48
6 phalp2_13122
8iXkc
 2 36,7% 223 1.485E-40
7 phalp2_11814
8vJeI
 1 35,4% 234 2.381E-39
8 phalp2_1024
6U3Fm
 2 30,1% 219 7.963E-31
9 phalp2_33891
1NRwq
 35 36,5% 205 1.465E-30
10 phalp2_28796
7G1A0
 2 24,3% 279 1.853E-23

Domains

Domains [InterPro]
Ami2
Representative sequence (used for alignment): 1HOCY (326 AA)
Member sequence: A0A6J5MA41 (219 AA)
1 326 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage uncultured Caudovirales phage
[NCBI] 		2100421 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LR796420 [NCBI]
CDS location
range 162987 -> 163646
strand +
CDS
ATGAAACTAACACAAACTGCATTTTCGGCAAATCAATACATAGCCGATGAACGCCCTAAGAGGCAAATTTACATACACCATACCGCTGGCAACGCTGATCCGTTTGGTGTGTTTAAATTTTGGGAAAGTAATCGTGAGCGAATAGCAACATGTGTAACGATTGGAGGTAAACCCCGTCGTGGATCCAATTGGCAGGATGGGGAAGTTGTACAGGGGTATAGCTCTAGATTTTGGGCATTCCACTTAGGTCTCACAGAATCGACTTTTCAAAAATTTAATGTACCATATATTTCGCTAGATAAAATTTCTATTGGAATCGAAATTTGTAACTGGGGGCAACTGACTCTTAAAAATGGTAAGTTTTACAATTGGGCAAACGGTGAAGTGCCTGCTGATGAAGTGTGTGAACTGAAAACCGAACATAGAGGATTTAAGTATTATCATAACTATACCGATGCTCAAATCGATGCTGTAAAAGACCTTCTACTATTGTGGAAGCAGCGATATAATATTCCACTTGAGTATCACGCTGATATTTGGGATGTTACACCGAGAGCACTTCGTGGTGAAGCTGGTGTATTTACTCACAATTCGGTAAGATATGATAAAGTTGACGTATATCCGCATCCAAAATTAGTTAGTATGTTAAAATCGTTATAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (1HOCY) rather than this protein.
PDB ID
1HOCY
Method AlphaFoldv2
Resolution 82.17
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50