Protein

Protein accession
A0A6G5XY21 [UniProt]
Representative
7o1p2
Source
UniProt (cluster: phalp2_1666)
Protein name
N-acetylmuramoyl-L-alanine amidase domain protein
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKRNYKYALSDHEGSSHRAKPNFIVAHSTATPNGEAWAVARNMKTGINTSQTYTHLVVDDENIYQVGEVGYDAWGAGMPANSMSPVQIELCEFTNHKRAMKAYKHYVNWLRWGAKKYGIPLTLDNDKPTGIKTHAWLVQHGYSNTNHTDPWGYLTKLGITKAQFAKDLKKGFSGENIKNTK
Physico‐chemical
properties
protein length:181 AA
molecular weight:20401,8 Da
isoelectric point:9,46
hydropathy:-0,72
Representative Protein Details
Accession
7o1p2
Protein name
7o1p2
Sequence length
234 AA
Molecular weight
26211,55540 Da
Isoelectric point
9,51993
Sequence
MRREELKKLALIDEQIDKVMSLHGADVEAMKAKTDELGKTNQSLQSQIAERDKDLKTLKKQTGDNKGSSQLATPRLIIAHSTATPNGEAWAISRNMKNGINVSQTYVHFVIDDKSIYQVGELGYVAWGAGSPANSLAPVQIELCEFSNHRRALKAYKHYVNWLRWSAKKYGIPLALDTNSYRGIKTHSWLVQHGYSNTDHTDPWQYLPKIGISKAKFAKDLTKGFSGLNIALTK
Other Proteins in cluster: phalp2_1666
Total (incl. this protein): 22 Avg length: 214,9 Avg pI: 9,55
Protein ID Length (AA) pI
7o1p2 234 9,51993
7ccWf 181 9,60548
7o1m2 213 9,45856
7o1ml 181 9,68349
7o1nI 181 9,52077
7o1nY 181 9,51987
7o1pG 181 9,54321
7o1q9 190 9,79238
7o1t1 181 9,65422
7o1uU 181 9,59485
7vQbQ 181 9,40589
A0A6G5XUV1 265 9,84395
A0A6G5XXQ9 383 7,65515
A0A6G5Y1E7 265 9,77349
A0A6G5YAX6 265 9,90094
A0A6G5YGS4 265 9,79824
A0A6G5YKC3 181 9,57531
A0A6G5YLP5 211 9,81236
A0A6G5YLU4 265 9,84369
A0A6G5YNQ9 181 9,59485
A0A6G5YNY0 181 9,52051
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_18587
7keSn
 482 46,7% 156 8.387E-38
2 phalp2_32244
7rT4s
 46 33,7% 160 1.019E-26
3 phalp2_8663
7V0AW
 3 26,8% 175 5.113E-10
4 phalp2_13982
kgnW
 11 28,3% 155 2.415E-08
5 phalp2_6407
bpom
 66 25,2% 174 1.479E-06
6 phalp2_27158
38a6k
 24 28,1% 160 3.554E-06
7 phalp2_32230
7h6JD
 19 23,3% 154 2.770E-04

Domains

Domains [InterPro]
Unannotated
Ami2
Representative sequence (used for alignment): 7o1p2 (234 AA)
Member sequence: A0A6G5XY21 (181 AA)
1 234 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Caudoviricetes sp
[NCBI] 		2832643 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MN855648 [NCBI]
CDS location
range 7760 -> 8305
strand +
CDS
ATGAAAAGAAATTACAAATACGCATTGTCAGACCATGAAGGTAGTTCACACAGAGCAAAACCTAACTTTATCGTTGCCCACTCAACCGCAACACCAAATGGTGAAGCTTGGGCGGTAGCACGCAATATGAAGACTGGAATTAATACTAGCCAAACATATACACATCTAGTAGTTGATGACGAAAATATTTATCAAGTTGGTGAAGTTGGCTATGACGCATGGGGTGCAGGTATGCCAGCTAACAGCATGTCGCCAGTACAGATTGAGCTGTGTGAGTTTACCAACCATAAGCGCGCGATGAAAGCATACAAGCACTATGTTAATTGGTTACGCTGGGGTGCCAAAAAATATGGTATCCCTCTAACTTTAGATAACGACAAGCCAACAGGCATTAAGACGCATGCATGGCTAGTCCAACATGGTTACAGTAATACTAACCACACTGATCCATGGGGCTATCTAACTAAGTTAGGTATTACAAAAGCACAATTTGCTAAAGACTTGAAAAAAGGTTTTAGCGGCGAAAACATAAAAAATACTAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7o1p2) rather than this protein.
PDB ID
7o1p2
Method AlphaFoldv2
Resolution 92.81
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50