Protein

Protein accession
A0A125V8N7 [UniProt]
Representative
4613D
Source
UniProt (cluster: phalp2_37687)
Protein name
Cell-wall hydrolase
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MNIKNKKHILKKFIAMVLIAGVVTVEAGAITASAAEPTNSPMSATVDQCDFLNVRSGASANDAVVGKINTGDKVEVLELHSNGWIKIKSVDNVTGWVNGDYLTIQGGNVDAKVQNVLNLAFKQQGKPYKWGATGPNSFDCSGFTSYVYKNGAGVNLPRVSRSQATVGKKVSRAELKPGDLVFFGSGGSINHVGLYVGDSKFIHSPQTGDVVKVTSMAPGTNYAKRLITATRVLQ
Physico‐chemical
properties
protein length:234 AA
molecular weight:24816,0 Da
isoelectric point:9,60
hydropathy:-0,10
Representative Protein Details
Accession
4613D
Protein name
4613D
Sequence length
144 AA
Molecular weight
15537,74100 Da
Isoelectric point
10,46910
Sequence
MIAVTLAVAAFVALTYLRRSLPTSTIARAIASARAQIGKPYKWGAVGPDSFDCSGLMWFAWKQAGVSFARLTANELFNRLRRVSRADLQPGDMVFFGTAGNLHHVGLYVGNGQMVHAPNSKSTVKESPIASMSDFYAGGRLRAT
Other Proteins in cluster: phalp2_37687
Total (incl. this protein): 7 Avg length: 167,0 Avg pI: 9,94
Protein ID Length (AA) pI
4613D 144 10,46910
A0A2Z4QBH5 159 9,87419
A0A2Z4QBQ0 159 9,91338
A0A5J6TDR2 163 9,95142
A0A9E7TB59 155 9,87922
A0AAX4RAE8 155 9,91306
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_39666
6UgY6
 16 43,3% 120 1.020E-30
2 phalp2_20916
72mid
 3 45,5% 112 3.270E-29
3 phalp2_27434
4StvA
 61 36,5% 134 2.445E-26
4 phalp2_2843
8JxjE
 191 38,9% 113 2.753E-24
5 phalp2_29089
6VxI8
 38 39,8% 108 5.168E-24
6 phalp2_24590
56wtZ
 13 37,5% 128 5.168E-24
7 phalp2_24984
CFMj
 3 39,8% 123 1.648E-22
8 phalp2_12592
1nAeA
 3 46,5% 101 1.490E-21
9 phalp2_14699
6wXZL
 6 43,3% 90 2.041E-21
10 phalp2_13815
74q4c
 2 40,0% 100 2.795E-21

Domains

Domains [InterPro]
NLPC_P60
Representative sequence (used for alignment): 4613D (144 AA)
Member sequence: A0A125V8N7 (234 AA)
1 144 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00877

Taxonomy

  Name Taxonomy ID Lineage
Phage Peptoclostridium phage phiCDIF1296T
[NCBI] 		1677909 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
CP011968 [NCBI]
CDS location
range 3074535 -> 3075239
strand -
CDS
ATGAATATTAAAAATAAAAAACATATATTGAAAAAATTTATAGCTATGGTGTTAATAGCAGGAGTTGTCACAGTAGAAGCAGGAGCAATAACGGCTAGTGCAGCAGAGCCAACTAATTCACCTATGAGTGCAACAGTAGACCAGTGTGATTTTTTAAATGTAAGAAGTGGAGCTAGTGCAAATGATGCAGTAGTAGGAAAGATAAACACAGGAGACAAAGTTGAAGTTTTAGAATTACATTCAAATGGATGGATTAAAATAAAAAGTGTTGACAATGTTACAGGATGGGTAAATGGAGATTATTTAACTATTCAAGGTGGAAATGTAGATGCAAAGGTACAAAATGTTTTAAACTTAGCATTTAAGCAACAAGGTAAGCCATATAAATGGGGAGCAACTGGACCAAATTCTTTTGATTGTTCTGGGTTCACTTCTTATGTCTATAAAAATGGAGCAGGAGTTAATTTACCAAGAGTATCAAGATCACAAGCAACAGTAGGAAAGAAAGTATCAAGAGCAGAATTAAAACCAGGAGATTTAGTTTTCTTTGGTTCAGGTGGTTCAATAAATCACGTTGGATTGTATGTAGGAGATTCTAAATTCATACATTCACCACAAACAGGAGATGTAGTAAAAGTTACTAGCATGGCTCCAGGAACTAATTATGCAAAAAGACTTATAACTGCTACACGTGTTTTACAATAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008234 cysteine-type peptidase activity molecular function None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
A0A125V8N7
Method AlphaFoldDB
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
upi00017f5872_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (4613D) rather than this protein.
PDB ID
4613D
Method AlphaFoldv2
Resolution 91.46
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50