Protein

Protein accession
A0A125V1D1 [UniProt]
Representative
2tcS7
Source
UniProt (cluster: phalp2_20323)
Protein name
Cell wall endopeptidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 89% (predicted by ML model)
Protein sequence
MKKKLLEKDGFYLSLFVCVCLLAVGGVWFTNNNVDKLASNKGIMENANKDSEEEIHLIEKDKKDAIPTATDSKQNLEKAKSKEENKSSTTKLNYIGDKVIRGYSEKEPSYSKTLDVWETHKGVDISCTKGKEVKSLLNGIVVDVFDDEEYGQSVKIKSDNNIVVVYSNLDKNVSVKKEQKVTEGQSLGTVGSTSQIESEEGIHVHLEAYSGEKSIDPMSLIK
Physico‐chemical
properties
protein length:222 AA
molecular weight:24656,6 Da
isoelectric point:5,55
hydropathy:-0,58
Representative Protein Details
Accession
2tcS7
Protein name
2tcS7
Sequence length
214 AA
Molecular weight
22468,73390 Da
Isoelectric point
6,09583
Sequence
MGIFKMLTYPVTTKFGEIDRVHPTPHTGVDFACPAGTPAQSISDGIISKIANDQFLGESIRVKTDVGKEWVYGHLSQVNVTYGQHVSIGDTLGLTGGVPGTPGAGHSTGPHIHLTLLKDGIPVDPLAALVGPDGGSGWWGKIGDALINPPHVPTATERILDYLSTLIHIMPEVFGLLTMCFLLAGMVGSRRFMSYAGTSVLLAMVGVVLNAAIS
Other Proteins in cluster: phalp2_20323
Total (incl. this protein): 12 Avg length: 217,6 Avg pI: 7,08
Protein ID Length (AA) pI
2tcS7 214 6,09583
1cDjn 218 5,95107
1nwB2 218 9,04880
2A377 223 5,03022
2GVlS 217 7,95284
2sDBx 215 7,96541
2sFnM 216 9,15601
2sFxq 214 7,97662
2sJzi 220 6,12340
2tl2M 215 7,96560
86LjY 219 6,16415
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_27522
5hQNe
 27 34,7% 167 2.253E-25
2 phalp2_2348
4TuWR
 59 27,5% 214 5.723E-25
3 phalp2_2299
4FrFd
 1 31,3% 150 1.294E-11
4 phalp2_39288
4dsh8
 2 23,4% 158 6.528E-10

Domains

Domains [InterPro]
PET_M23
Disordered region
Representative sequence (used for alignment): 2tcS7 (214 AA)
Member sequence: A0A125V1D1 (222 AA)
1 214 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01551

Taxonomy

  Name Taxonomy ID Lineage
Phage Peptoclostridium phage phiCDIF1296T
[NCBI] 		1677909 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
CP011968 [NCBI]
CDS location
range 175925 -> 176593
strand +
CDS
ATGAAGAAAAAGCTGTTAGAAAAAGATGGTTTTTATTTATCTTTGTTTGTATGTGTTTGTTTATTAGCAGTAGGTGGAGTTTGGTTTACAAATAATAATGTAGATAAATTGGCTTCTAATAAAGGAATTATGGAAAATGCTAATAAAGATAGTGAAGAGGAAATACATTTAATTGAAAAAGACAAGAAAGATGCTATCCCTACTGCAACGGATTCAAAACAAAACTTAGAAAAAGCTAAGTCAAAAGAGGAAAATAAATCGAGTACAACAAAATTAAATTACATTGGAGATAAAGTAATAAGAGGATATTCAGAAAAAGAGCCTAGTTATTCTAAAACACTTGATGTTTGGGAAACTCATAAAGGTGTAGATATTAGTTGTACTAAAGGCAAAGAAGTAAAATCTCTATTAAACGGAATAGTAGTAGATGTATTTGATGATGAAGAATATGGACAATCAGTCAAAATAAAAAGTGACAATAACATTGTAGTAGTATATTCAAATCTAGATAAAAATGTTAGTGTTAAGAAAGAACAGAAGGTAACAGAAGGACAATCTCTAGGTACTGTAGGTAGTACTTCTCAAATAGAAAGTGAAGAAGGTATACATGTGCATTTAGAGGCGTATAGTGGAGAAAAATCTATAGACCCAATGAGTCTAATTAAGTAA

Gene Ontology

Description Category Evidence (source)
GO:0004222 metalloendopeptidase activity molecular function None (UniProt)
GO:0016020 membrane cellular component None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
A0A125V1D1
Method AlphaFoldDB
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
upi0000da4dcf_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (2tcS7) rather than this protein.
PDB ID
2tcS7
Method AlphaFoldv2
Resolution 79.21
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50