Protein

Protein accession
F5B3T1 [UniProt]
Representative
22sRD
Source
UniProt (cluster: phalp2_29814)
Protein name
Lysozyme
Lysin probability
99%
PhaLP type
VAL
Probability: 99% (predicted by ML model)
Protein sequence
MASSVLSGILKVDVNTKKSIQSIDATLEKIYKLEIDKNKRDIREKKATEQANKTKEKERNILDDILKELKGKKKEEKKESFLAGLLKNIGPAITAAGPVIGKAFAGLLAAGGALGAVITKGMGALFKVGGPIFAVVASALVGWKLGEWLNKNIIDKQVKPWLERQGNKVNKFTDKATGGGQSRNVSTLEATKLIKEKRSAMMGNPMWGVPALQGIAKENTQKDIDALTEIVHSIRDRKRLNDLLYDARQEGKQQKIDELTKEIKEKEDKIDRLVSSRPGLLQELGVQKKQRGGPITVPGTGSGDKIPMMLPPGSFVMNRNASAMLQSGGLVPTLLEPGEKVFAPGDVSPMHHMLNSMIPRFQTGGEVTKQNTAKETVVTKGKDKASSGGGLPAVVAAGIELIKKGFTVGEHKNFIKGPPSKYSPEGKGRVGGHSPNSLHYSGRAIDVTDWRNGDWRGRTRKLAEEVFSNRERLKLTQIIHDPWGSWFAGESKKGGPIGGHGEHLHLGFAKGTGLDLGTWGIGNKENNPSAPSDGTPQDPQSTIAGEFSGLGEVGKAITSVFAGFGNAMGPNAGPLFNAMFGLSSGSSTPSPSTENNNNSGGGGSVAVGGPFDKNLAKLLKNYEGLRTSAYKDAVGIPTIGIGATYYPKGFRLSGKVQMGQKITETEAEFIKEQHIKEHRGRLLREISSSEYSKVPDNVKAALESKTFNYGSLGGPLSKLVKQGVQSKEYGPVSGYFRSTLAKHDGGLNSWRRNDEANIIDTGKSKRANVAFSKNATMLQTGGLVNMSPTQSNNTTRFKQAQEEFAQMIAEKSGGPIIVMAGGNQQSPTVIPAPASQPAPPSLPDGPSSIQAAEYFYRLNMGSVI
Physico‐chemical
properties
protein length:864 AA
molecular weight:92465,3 Da
isoelectric point:9,68
hydropathy:-0,49
Representative Protein Details
Accession
22sRD
Protein name
22sRD
Sequence length
610 AA
Molecular weight
64968,09570 Da
Isoelectric point
9,49518
Sequence
MDDIGTKPTVRNKTISTSKFFGAEDKSSLGKVGQEKSKISSLSKIVRNNRIKISQLEKNDEVLNSILDELISLRSTVNSIGKSIKKQQKLQQKVVARNKIIEDKQAKKSREEKLETRPSGKSKILEKAEKPVIGFFDRIIEFFKMILLGGGLSYLLNVIKDPQILLKPLQDLVNNVISFFNGIIEWIDSTLIDPLRSIVDSLNGGLQNIVNVLNGIISSIPDWMPFKPDAIEQAPQIPQIPSLPEIPKATFADPKVQAQSNGGQILNINEGNTIINAKDLKFKSGGQVGTDSGITINGLGPDTQLIAAQPGEIVMNKSAVDGYGADNLLSLNSIFGGSNANKPKMVSGGKIMSAQGGGQVRKHMRKGEKSSAQVKNPTTNTSQEKDVKKGVDDKPGSGGLPAVVSAGKQLLSSGFTVAEHPNFGKGTGYDPKGKQRVGGHSPNSAHYKNLAIDVTDWRDGDWKGRTKSLAQSMFEQKDKLKLTQIIHDPWGSWFKGESKPGAAIGGHPTHLHLAFENGPGGDIESTQGSDYSGKISSSSGGSKGSIMGSSITPPSVSGGGMMPIPIPSGGKQSTQSSSAGSGQSPAPSFSSEDTMNPSLLVVKAIYNIVG
Other Proteins in cluster: phalp2_29814
Total (incl. this protein): 17 Avg length: 757,5 Avg pI: 8,96
Protein ID Length (AA) pI
22sRD 610 9,49518
13W9A 829 9,70199
1Fbwn 859 9,76878
1iMtA 737 9,91699
1yro 871 9,67208
29xjF 693 9,41885
2IlXC 753 5,39677
2pNN 627 9,38893
2pW2a 823 9,08032
3ZeO5 852 9,68729
4DOAp 735 9,74357
4XYfh 634 9,41885
5v6Ot 818 8,42423
AExg 749 5,30594
tLlC 636 9,35702
wwi 787 8,85494
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_20122
24cuN
 93 31,3% 641 1.550E-68
2 phalp2_18234
4S1ms
 59 30,3% 616 3.807E-63
3 phalp2_29832
26Mlw
 21 19,0% 557 1.176E-05

Domains

Domains [InterPro]

No domain annotations available.

Taxonomy

  Name Taxonomy ID Lineage
Phage Synechococcus phage S-CRM01
[NCBI] 		1026955 Kyanoviridae >
Host Synechococcus sp.
[NCBI] 		1131 Cyanobacteria > Oscillatoriophycideae > Chroococcales > Synechococcus >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
HQ615693 [NCBI]
CDS location
range 65579 -> 68173
strand -
CDS
ATGGCTTCAAGTGTATTATCTGGAATTCTTAAAGTAGATGTGAATACCAAGAAGAGTATTCAATCGATTGATGCTACTTTGGAGAAAATCTATAAGTTAGAAATAGATAAGAACAAAAGAGATATCCGAGAAAAGAAGGCAACAGAGCAGGCAAACAAAACAAAAGAAAAAGAAAGAAATATTCTTGATGATATTCTCAAAGAACTCAAAGGAAAGAAAAAAGAAGAGAAAAAAGAAAGTTTCTTAGCCGGTCTGTTAAAAAACATTGGGCCCGCAATTACAGCGGCTGGACCGGTAATTGGTAAAGCATTCGCTGGTCTTCTCGCGGCTGGTGGTGCACTAGGTGCAGTGATTACAAAAGGAATGGGAGCACTATTTAAGGTAGGTGGTCCTATTTTTGCTGTAGTTGCCTCCGCCTTGGTAGGTTGGAAATTGGGAGAATGGCTGAATAAAAATATCATCGATAAACAAGTAAAGCCATGGCTCGAAAGACAAGGAAATAAAGTCAACAAATTTACAGACAAAGCGACTGGTGGTGGACAATCTAGAAACGTTTCAACTCTAGAGGCAACCAAATTAATCAAAGAAAAAAGATCTGCAATGATGGGAAACCCAATGTGGGGAGTTCCTGCTTTGCAAGGTATCGCAAAAGAAAATACACAAAAAGATATTGATGCCCTTACGGAAATAGTTCATTCTATTAGAGATAGAAAGAGATTAAACGATTTACTATATGACGCAAGACAAGAAGGTAAACAGCAAAAAATAGACGAACTTACAAAAGAAATAAAAGAGAAAGAAGACAAAATCGATAGACTTGTATCATCCAGACCAGGATTGTTACAAGAATTAGGAGTTCAAAAGAAACAACGTGGTGGACCTATTACTGTTCCTGGGACTGGATCAGGTGATAAAATACCCATGATGCTTCCTCCCGGTTCATTCGTTATGAACCGTAATGCATCGGCGATGTTACAGAGTGGTGGATTGGTTCCAACTCTCCTAGAACCCGGAGAAAAAGTATTTGCGCCGGGGGATGTGAGTCCTATGCATCATATGTTAAACTCTATGATTCCTAGATTTCAAACTGGTGGAGAAGTTACCAAACAAAATACTGCTAAAGAAACAGTAGTAACAAAAGGAAAAGATAAGGCCTCTTCTGGTGGCGGACTTCCAGCGGTTGTTGCCGCTGGAATAGAACTCATCAAAAAAGGATTCACTGTCGGTGAACATAAAAACTTTATAAAAGGACCACCTAGCAAATACTCACCAGAAGGTAAAGGCAGAGTCGGCGGACACAGCCCAAATAGTTTACACTATTCCGGTAGGGCAATCGATGTCACTGACTGGCGGAACGGAGACTGGAGAGGTAGAACTAGAAAATTGGCCGAAGAAGTCTTTTCAAATAGAGAGAGACTTAAGTTAACGCAAATCATCCATGATCCATGGGGATCATGGTTTGCTGGAGAATCTAAAAAAGGGGGCCCAATTGGTGGCCACGGTGAACACTTGCATCTAGGTTTTGCAAAGGGGACTGGACTTGACCTAGGGACTTGGGGAATAGGAAATAAAGAAAACAATCCTTCAGCCCCGAGTGATGGAACACCACAAGATCCCCAGTCAACTATAGCTGGAGAATTTTCAGGGTTGGGTGAAGTTGGTAAAGCAATCACTTCAGTATTTGCTGGATTCGGTAATGCAATGGGCCCAAATGCTGGTCCATTGTTTAATGCAATGTTTGGTCTATCTTCAGGTTCATCAACACCATCACCAAGTACAGAAAATAATAACAATTCTGGGGGCGGGGGATCAGTAGCCGTCGGTGGACCGTTTGACAAAAATCTTGCAAAGCTTCTAAAGAACTATGAAGGCCTAAGAACAAGTGCTTATAAAGATGCAGTTGGAATTCCAACTATTGGAATAGGTGCAACATATTATCCTAAAGGCTTTAGACTATCTGGAAAAGTTCAGATGGGACAAAAAATAACTGAGACCGAAGCAGAATTCATTAAAGAGCAACACATCAAAGAACATAGAGGAAGATTACTTAGAGAAATTTCCAGTTCAGAATATAGTAAAGTTCCAGATAATGTTAAGGCAGCCCTGGAGTCAAAAACATTCAACTATGGTAGCCTAGGTGGGCCACTCTCAAAATTAGTAAAACAAGGAGTACAAAGCAAAGAATATGGTCCAGTTTCTGGGTACTTCAGAAGTACACTCGCAAAACATGATGGAGGATTAAATTCCTGGAGAAGAAACGACGAGGCTAATATTATTGATACAGGAAAAAGTAAAAGAGCTAATGTCGCCTTCTCTAAAAATGCAACAATGCTTCAAACTGGAGGTTTAGTAAATATGTCTCCAACTCAATCGAATAATACAACCAGATTCAAGCAGGCACAAGAAGAGTTTGCACAAATGATTGCTGAAAAATCAGGTGGTCCTATCATCGTAATGGCCGGAGGAAATCAACAATCACCAACTGTTATTCCGGCACCAGCATCACAACCTGCTCCACCAAGCTTGCCTGATGGTCCATCTTCTATTCAAGCTGCGGAATACTTCTATAGACTCAATATGGGTTCTGTCATCTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

PDB ID
upi000209e367_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (22sRD) rather than this protein.
PDB ID
22sRD
Method AlphaFoldv2
Resolution 62.14
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50