Protein

Protein accession
A0AB39CC00 [UniProt]
Representative
41rlL
Source
UniProt (cluster: phalp2_21403)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MGIKTRVGYCSVAVVLALVSTNHKGEIRTSPAGLELLAGYEDCRTQAYLDIVGVPTCGIGSTSGVRMGTTWTEAQVAAAFVKDVQAAEKCVLVYFNGYAMPQPVFDSVTSLVFNAGCWGTRWNTKLNRPTGIAQYAKAEDWQNVCYRLGDFIYAGGKVSNGLKNRRAKEQAHCVKWQVPQQYEGSRWTPNPH
Physico‐chemical
properties
protein length:192 AA
molecular weight:21058,8 Da
isoelectric point:8,97
hydropathy:-0,21
Representative Protein Details
Accession
41rlL
Protein name
41rlL
Sequence length
243 AA
Molecular weight
27327,94670 Da
Isoelectric point
9,34825
Sequence
MFTSNAGRNLIKQYEGCKLKAYKCPSGVYTIGYGHTKGVKADMRITKAQAEDLLTQDLATVESAVNIYVNRYKLNQNEYDSLVSFTFNCGAGNLNKLCNKGLRKKSAIADKMLAYNKGNGKVLAGLTARRLAERKLFLTPVSTVAMGIDYSHVFDANYYANRYSDLKKAFGTDAKALFEHFLVYGMREHRQAIATFNVDKYISYSSNADVVNACTNPKTKELDIVKVYKHYCEFGYKENREAV
Other Proteins in cluster: phalp2_21403
Total (incl. this protein): 6 Avg length: 198,0 Avg pI: 8,94
Protein ID Length (AA) pI
41rlL 243 9,34825
A0A9E7M7I9 192 8,97047
A0A9E8G8Z5 192 8,97047
A0A866D1Q0 177 8,69403
A0AAD2GRE8 192 8,65954
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_34008
81fvs
 10 42,5% 162 1.770E-38
2 phalp2_16385
5LDDR
 25 50,0% 186 4.005E-37
3 phalp2_26378
1q5mp
 207 46,2% 158 1.374E-24
4 phalp2_28322
16R6i
 5 36,8% 187 1.188E-19
5 phalp2_23227
7HiLX
 27 39,6% 179 2.972E-19

Domains

Domains [InterPro]
GH24
Unannotated
Representative sequence (used for alignment): 41rlL (243 AA)
Member sequence: A0AB39CC00 (192 AA)
1 243 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Klebsiella phage vB-Kvc-Y10
[NCBI] 		3236922 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
PQ014581 [NCBI]
CDS location
range 3784 -> 4362
strand -
CDS
ATGGGTATCAAAACTCGCGTAGGCTACTGCTCGGTGGCCGTAGTCCTGGCCTTGGTCAGTACCAACCACAAGGGCGAGATTCGCACCTCTCCCGCCGGGCTGGAGCTTCTGGCTGGCTATGAGGACTGCCGCACCCAGGCCTATCTGGACATCGTAGGAGTCCCTACGTGCGGAATTGGTAGCACCTCTGGGGTTCGTATGGGCACTACCTGGACAGAGGCTCAGGTGGCCGCTGCGTTCGTTAAGGACGTACAGGCGGCCGAGAAGTGCGTCCTGGTGTACTTCAACGGGTACGCTATGCCGCAGCCAGTATTCGACTCTGTGACCTCTCTGGTGTTCAATGCCGGGTGCTGGGGTACTCGCTGGAACACTAAGCTGAATCGGCCTACCGGTATCGCGCAGTACGCTAAGGCAGAGGACTGGCAGAATGTGTGTTACAGATTGGGCGACTTCATCTACGCCGGAGGGAAGGTCTCTAATGGCCTCAAGAACCGCCGAGCTAAGGAGCAAGCCCACTGTGTCAAATGGCAAGTACCGCAACAGTATGAGGGTTCCCGATGGACACCAAATCCCCACTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
A0A9E7M7I9
Method AlphaFoldv2
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
A0A9E8G8Z5
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
A0AB39CC00
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (41rlL) rather than this protein.
PDB ID
41rlL
Method AlphaFoldv2
Resolution 97.40
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50