Protein

Protein accession
A0AB39ABP6 [UniProt]
Representative
7xiDE
Source
UniProt (cluster: phalp2_16574)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MLRKLKMTGGIIGVAAAALLATSLPEKEGMVLTTYPDIVGKPTVCAGHTGEFAIAGKTYTTSQCWDILDKDVAKHAVPVIKCSPWLLNTNPYFIQAAIDHAFQFGPNKWCTSEAKKYGQSGDYKKMCLLFSQTLTGGINWSQAGGKYSRGVHNRSKWRTETCRKGL
Physico‐chemical
properties
protein length:166 AA
molecular weight:18161,9 Da
isoelectric point:9,43
hydropathy:-0,21
Representative Protein Details
Accession
7xiDE
Protein name
7xiDE
Sequence length
253 AA
Molecular weight
27724,15740 Da
Isoelectric point
11,00890
Sequence
MTQIDWREASRWWSVRVSALGSLLYAAMLLMPDQLLGLWNMMPAEVRTLLPARAGNWLGMILFALVIVARVLPQRSARDGASLWRALFRSAKGAVSPNSAKRAALIATALALAVVGLKADEGKRNTSYLDIVGIPTACYGHTGPDVRPGQVRTDAQCETLLRADARGHMAGALACSPMLADHPNQLAAVTRLTFNIGVRGYCRSSIARHFAAGRWRQGCDCFLAFRYAGRREVRGLLLRRRRERALCLTGLPA
Other Proteins in cluster: phalp2_16574
Total (incl. this protein): 15 Avg length: 198,1 Avg pI: 9,72
Protein ID Length (AA) pI
7xiDE 253 11,00890
2prjn 274 9,48989
5JfgW 249 10,53782
5suH1 252 9,85207
5sv1v 249 10,71099
A0AAX4QIJ5 201 9,76311
A0A9E7N2R8 168 9,28391
A0AA49CMQ3 164 9,40969
A0AAE9WXD3 166 9,42568
A0AAF0B9B3 166 9,24872
A0AB39ABH8 166 9,42568
A0AB39ABT4 166 9,42568
A0AB39AC28 166 9,42568
A0AB39AC46 166 9,42568
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_35864
4Lj4w
 95 39,3% 165 4.975E-36
2 phalp2_1418
1rFir
 138 34,8% 267 6.790E-36
3 phalp2_12784
8jI3j
 17 29,4% 180 8.174E-35
4 phalp2_15038
7cXTn
 20 36,7% 155 1.469E-29
5 phalp2_5806
4ZKl2
 35 33,5% 191 9.399E-29
6 phalp2_33109
4K52y
 18 32,5% 160 1.114E-27
7 phalp2_2632
6RhYr
 14867 34,4% 154 8.369E-26
8 phalp2_15055
7rwX8
 6 29,4% 248 1.139E-25
9 phalp2_3556
4E0oc
 53 34,7% 164 8.456E-24
10 phalp2_8851
2IyxA
 73 32,7% 177 4.564E-22

Domains

Domains [InterPro]
Disordered region
Unannotated
GH24
Representative sequence (used for alignment): 7xiDE (253 AA)
Member sequence: A0AB39ABP6 (166 AA)
1 253 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Pectobacterium phage Koroua
[NCBI] 		3158138 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
PQ008972 [NCBI]
CDS location
range 35037 -> 35537
strand +
CDS
ATGTTGAGAAAGCTTAAGATGACTGGCGGGATCATCGGCGTGGCAGCAGCGGCGCTCTTAGCAACATCATTGCCAGAAAAAGAGGGGATGGTTCTAACCACATATCCCGATATCGTCGGGAAACCCACGGTGTGCGCAGGACATACCGGAGAATTTGCGATAGCTGGCAAGACGTATACTACAAGTCAATGCTGGGATATTCTTGACAAAGATGTAGCTAAACACGCCGTTCCCGTCATCAAATGCTCACCGTGGTTACTCAACACAAACCCCTATTTCATTCAGGCTGCTATAGACCACGCTTTCCAGTTTGGGCCAAACAAATGGTGTACCAGCGAAGCGAAAAAATATGGTCAGTCTGGCGACTATAAAAAAATGTGCCTGTTATTCAGCCAAACGTTAACGGGAGGCATTAACTGGTCGCAAGCTGGCGGAAAATACTCAAGAGGCGTTCATAATCGGTCAAAATGGCGAACCGAAACGTGCAGGAAAGGATTGTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7xiDE) rather than this protein.
PDB ID
7xiDE
Method AlphaFoldv2
Resolution 84.65
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50