Protein

Protein accession
A0AAX4QGZ2 [UniProt]
Representative
5fckM
Source
UniProt (cluster: phalp2_37960)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MAEPTTQGAKIVGGSMAGVFLLAMALLQPWEGYSARPYRDIVGVLTVCHGHTSRVEQREYSHEECGRLLASDMGEAWNTVQRCIDAPMTEYQAAAMLSFAFNVGPGRKGVKDGLCVLRNGNQPRIRVYANQGRWDLACAQLPNWALAGGKRSRGLENRRAAERAMCEGRAQ
Physico‐chemical
properties
protein length:171 AA
molecular weight:18755,2 Da
isoelectric point:9,03
hydropathy:-0,34
Representative Protein Details
Accession
5fckM
Protein name
5fckM
Sequence length
350 AA
Molecular weight
37592,84260 Da
Isoelectric point
6,94387
Sequence
VTARDIIRESEGLRLKAYPDPATGGRPYTIAFGHTKGVKLGDTCTPEQAEAWLTEDMADAYRVVASAVTVPLTEKQRDALCSFVFNVGPGVKGSKDGFVRLKSGSPSTMLRKLNADDYSGAAAEFPKWNKGAGKPMRGLTIRRGKERALFLSGTGVSAEPIPPLEEKPVAPFLIAAIPSLIAAIPEFAKIFTKPDVAARNVEAAMKAVDIVVQATGATNVQEAVEKVESEPEAVAAANTALRMSQADVMDLFERMVAMDEKSVGDARMFYQIDKPLLGNWRFAHILSLLLVFMGGGAACYVLVTSQDATERAMALQTLLVVGFASVASFWLGSSRGSQMKDAMRESNRDV
Other Proteins in cluster: phalp2_37960
Total (incl. this protein): 10 Avg length: 321,2 Avg pI: 7,16
Protein ID Length (AA) pI
5fckM 350 6,94387
4KYK2 331 6,37150
4kzlv 341 8,75044
4zkyI 420 5,02857
5z5ni 353 5,89246
6Rd43 357 7,70807
6VDqw 370 6,48063
XJSj 350 5,78061
A0AAF0KB46 169 9,58079
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_37963
5hjd8
 62 39,2% 392 1.835E-86
2 phalp2_20036
1pDJr
 122 28,8% 406 2.377E-33
3 phalp2_34480
4HCcy
 3 33,1% 232 1.463E-27

Domains

Domains [InterPro]
GH24
Unannotated
Unannotated
Unannotated
Unannotated
Representative sequence (used for alignment): 5fckM (350 AA)
Member sequence: A0AAX4QGZ2 (171 AA)
1 350 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Leptolyngbya phage Lsp-JY19
[NCBI] 		3128137 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
PP438411 [NCBI]
CDS location
range 11570 -> 12085
strand +
CDS
ATGGCTGAGCCGACTACCCAAGGCGCCAAGATCGTGGGCGGCTCGATGGCGGGCGTGTTCCTGCTTGCCATGGCCCTACTGCAGCCCTGGGAGGGCTACTCCGCGCGGCCCTACCGCGACATCGTCGGCGTGCTCACCGTCTGCCATGGCCACACCAGCCGGGTGGAGCAGCGCGAGTACAGCCACGAGGAGTGCGGCCGGCTGCTGGCCAGCGACATGGGCGAGGCCTGGAACACGGTGCAGCGCTGCATCGACGCGCCGATGACCGAGTACCAGGCAGCGGCCATGCTGTCGTTCGCCTTCAACGTGGGCCCAGGGCGCAAGGGCGTCAAAGACGGCCTGTGCGTGCTGCGGAACGGCAACCAGCCACGCATCCGCGTCTACGCCAACCAGGGCCGATGGGACCTCGCCTGCGCGCAGCTTCCGAACTGGGCCCTGGCCGGCGGCAAGCGGTCGCGTGGCTTGGAGAACCGCCGCGCGGCCGAGCGCGCGATGTGCGAAGGCCGTGCCCAATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (5fckM) rather than this protein.
PDB ID
5fckM
Method AlphaFoldv2
Resolution 72.95
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50