Protein

Protein accession
A0AAX4NJ22 [UniProt]
Representative
4A8EL
Source
UniProt (cluster: phalp2_10898)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MRNVKNLEEQLRLDEGEKLSAYQDHLGFWTIGIGRLIDARKGGGITAEESSYLFNNDVKTKTAEVRRALPWFDSLDEARQGVLLNMAFQMGTAGLLGFKNTLAMVKAGDYKGAAAGMLQSLWATQTPQRAKRLSVQMETGQWQ
Physico‐chemical
properties
protein length:143 AA
molecular weight:15925,0 Da
isoelectric point:8,96
hydropathy:-0,41
Representative Protein Details
Accession
4A8EL
Protein name
4A8EL
Sequence length
102 AA
Molecular weight
11868,46650 Da
Isoelectric point
5,54518
Sequence
MKPQLLRQLQRDEGFKDHAYQDHLGYWTIGFGRLIDERKGGHITLEEGLFLLNNDIDNKTEELLKRLPWVNDLDDARKGVLVNMAFQMGVDGLLKFKNTLEL
Other Proteins in cluster: phalp2_10898
Total (incl. this protein): 88 Avg length: 134,0 Avg pI: 6,16
Protein ID Length (AA) pI
4A8EL 102 5,54518
11p1X 195 4,95468
13S3w 133 5,96027
1GCVW 142 5,86046
1NHeY 99 4,67082
1boBJ 139 9,29707
1mEXy 101 8,78699
1n6Id 132 5,72365
25Efn 156 8,82973
2673P 144 5,66670
26dRX 142 5,66016
26g0w 144 5,19772
2MIw 195 4,92836
2TFLA 142 5,66016
2cC9q 150 4,46637
2dg3M 195 4,92836
2diXv 195 4,91887
2uAD5 104 5,89832
2vyTx 145 5,33459
39QSb 89 4,83412
3APMC 148 4,97991
3APsU 148 4,89426
3Btn9 148 4,88323
3IOIb 150 5,18641
3J22S 102 4,64076
3J2nn 150 5,34448
3J4Xz 148 5,05574
3QACs 119 5,09427
3QxO1 154 6,51889
3Y9R8 87 8,05650
3zfKH 147 4,70737
42oNo 150 4,99231
4BEnZ 139 5,79214
4MLls 141 9,00058
4MacP 137 5,32868
4PF2A 110 7,83647
4Rd7H 125 4,91910
4RvIU 140 9,03765
4WmUD 143 4,91000
4c3lo 98 4,93603
4cpNN 84 5,11241
4e2lf 194 4,76086
4iRky 152 8,76817
4jpo6 139 5,24359
4nNH0 141 6,33513
4t2b6 136 5,81715
5A3SJ 142 5,86211
5DPMm 88 4,84651
5H7QV 84 4,24214
5JqL8 154 8,96647
5JzqN 145 6,30995
5jSBI 65 4,86163
5jdW1 140 9,11539
5m88v 141 6,30779
5qEtY 148 5,08922
5t9NT 133 5,51363
5yBYo 144 5,85751
6HVFo 111 5,48106
6Ic91 144 4,92774
6JOgM 100 6,04610
6NzrH 76 4,68503
6P9hJ 144 5,34573
6xxqO 98 5,00032
7CAQP 124 5,70774
7CD0s 141 9,12442
7CpIM 115 6,72692
7Uidb 141 9,34129
7VNCn 143 8,92766
7ZOFH 144 5,06051
7ZXrF 185 8,83057
831ki 144 6,08953
83Z6U 141 8,88885
83hSD 148 5,19596
88Mk2 142 5,56860
8DBvE 92 4,17723
8E07f 106 4,97707
8GFaP 125 6,57379
8hy4A 142 5,80880
8qqwX 143 4,82122
8s4dM 140 6,30944
8uk9S 148 5,05545
W78z 136 7,73166
d5hg 116 7,89565
j3wI 139 9,32885
pHe6 143 9,41904
sAaM 145 9,18463
usWx 75 4,26994
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_17008
8jNgs
 3526 57,7% 97 1.236E-46
2 phalp2_32797
2yPO8
 5731 48,0% 100 1.495E-41
3 phalp2_24770
6NaQ7
 5 36,6% 101 5.219E-30
4 phalp2_6928
2KMCh
 358 36,8% 114 1.349E-29
5 phalp2_30806
8BDvv
 4 37,6% 93 2.540E-29
6 phalp2_27968
RI1z
 5083 40,0% 100 3.486E-29
7 phalp2_7141
2F1c5
 58 44,7% 105 6.018E-28
8 phalp2_14448
4FjnP
 18 41,8% 98 8.259E-28
9 phalp2_8442
12q1i
 28 31,7% 107 1.555E-27
10 phalp2_17182
3bGOC
 87 39,2% 102 4.020E-27

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 4A8EL (102 AA)
Member sequence: A0AAX4NJ22 (143 AA)
1 102 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Enterobacteria phage FtMidnight
[NCBI] 		3040652 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
PP430152 [NCBI]
CDS location
range 40045 -> 40476
strand +
CDS
ATGCGAAACGTGAAGAATCTTGAAGAACAATTGCGCCTTGATGAAGGTGAAAAGTTGAGCGCGTACCAAGACCATCTTGGTTTTTGGACAATCGGAATTGGCCGCTTGATTGATGCCCGCAAAGGCGGCGGCATTACCGCTGAAGAAAGTTCATACTTGTTCAACAATGACGTTAAGACAAAAACCGCTGAAGTGCGCCGGGCGCTTCCTTGGTTCGATAGCCTTGATGAAGCGCGGCAAGGCGTTCTGTTGAACATGGCCTTTCAAATGGGTACGGCTGGCCTTCTTGGTTTCAAGAACACCTTGGCAATGGTCAAGGCCGGTGATTACAAAGGCGCGGCGGCTGGAATGCTGCAAAGCTTGTGGGCAACCCAAACCCCGCAACGTGCAAAGCGCCTTTCTGTTCAAATGGAAACAGGGCAATGGCAATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4A8EL) rather than this protein.
PDB ID
4A8EL
Method AlphaFoldv2
Resolution 94.79
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50